RESEARCH
化学科共通
キーワード:#有機元素化学 #反応中間体化学 #生体関連化学
生命科学の可能性を求めて未知な分野を元素で切り拓く
この研究室では、複素環化学、生物化学、細菌学、工業化学、分析化学、有機合成化学等の多岐に渡る分野で研究が進められてきました。最近では、有機元素化学、反応中間体化学、有機生物化学の研究が行われています。これらの基礎化学分野の研究から、生命科学の可能性を探究していくことを目指しています。
業績
2023年
In Vivo Imaging of Tumor Hypoxia by Maintaining Green Fluorescence of 9-Aminoanthracene Under Hypoxic Conditions
Yosuke Uchiyama, Shotaro Yamagishi, Takahisa Yamaura, Kazutoshi Kanazawa, Hiroko Maruyama.
Bioorganic & Medicinal Chemistry, 91, 117407 (2023)
https://doi.org/10.1016/j.bmc.2023.117407
2022年
Observation and Stereochemistry of Betaine Intermediates in the Reaction of Phosphonium Ylide Containing a Phosphaboratatriptycene Skeleton with Benzaldehyde
Yosuke Uchiyama, Shotaro Yamagishi, Takuya Yasukawa.
The Journal of Organic Chemistry, 87 (23) :15899-15913 (2022)
https://pubs.acs.org/doi/10.1021/acs.joc.2c02021
2021年
Observation of intermediates in Reaction of Non-stabilized Phosphonium Ylide Containing Phosphaboratatriptycene Skeleton with PhCHO
Yosuke Uchiyama, Shotaro Yamagishi, Takuya Yasukawa.
Phosphorus, Sulfur, and Silicon and the Related Elements, 197(5-6), 457-461 (2021)
https://doi.org/10.1080/10426507.2021.2021524
Synthesis, Structures and Properties of Novel Tricyclic Tetraalkylphosphoranes with Hydrogen and Chlorine Atoms at the Apical Position
Takayuki Kawashima, Atsushi Yatabe, Shin-ya Nakafuji, Junji Kobayashi, Yosuke Uchiyama
Phosphorus, Sulfur, and Silicon and the Related Elements, 197(5-6), 414-419 (2021)
https://doi.org/10.1080/10426507.2021.2013844
2020年
Fluorescence Fluoride Ion Sensor Utilizing Desilylation of N-Silylated 9- Aminoanthracene
Yosuke Uchiyama,Yu Yasuda,Hideyo Matsuzawa.
Current Green Chemistry, 7 (2) :249-254 (2020)
http://dx.doi.org/10.2174/2213346107999200616110841
2019年
Synthesis of N-Substituted Amidinoheteroles and Their Reactivity towards Burgess Reagent
Yosuke Uchiyama, Shinobu Kimura, Takanori Kurotaki, Yukihiro Sawamura, Yuichi Kikuchi, Shinya Abe, Jason W Runyon, Joshua S Dolphin, Chistoph Schinnen, Anthony J Arduengo III.
Phosphorus, Sulfur, and Silicon and the Related Elements, 195(1), 3-6 (2019)
https://doi.org/10.1080/10426507.2019.1669602
Crystal Structure of Burgess Inner Salts and their Hydrolyzed Ammonium Sulfaminates
Anthony J, Arduengo III, Yosuke Uchiyama, David A Dixon, Monica Vasiliu
Australian Journal of Chemistry, 72(11), 867-873, (2019)
https://doi.org/10.1071/CH19338
Observation of Intermediates in Wittig Reactions of Non-stabilized Phosphonium Ylides Bearing a Phosphaheteratriptycene Skeleton Containing Group 15 Elements with Benzaldehyde
Yosuke Uchiyama, Suguru Kuniya, Ryo Watanabe, Takemaru Ohtsuki
Phosphorus, Sulfur, and Silicon and the Related Elements, 194(4-6), 281-294 (2019)
https://doi.org/10.1080/10426507.2018.1521410
2018年
Heteroatom Effects Toward Isomerization of Intermediates in Wittig Reactions of Non-stabilized Phosphonium Ylides Bearing a Phosphaheteratriptycene Skeleton with Benzaldehyde
Yosuke Uchiyama,Suguru Kuniya,Ryo Watanabe,Takemaru Ohtsuki
Heteroatom Chemistry, 29(5-6), e21473, 1-17, (2018)
https://doi.org/10.1002/hc.21473
Wittig Reactions of Non-stabilized Phosphonium Ylides Bearing a Phosphaheteratriptycene Skeleton Containing Group 14 and 15 Elements with Benzaldehyde
Yosuke Uchiyama,Suguru Kuniya,Ryo Watanabe,Takemaru Ohtsuki.
Phosphorus, Sulfur, and Silicon and the Related Elements, 194 (4-6), 277-278 (2018)
https://doi.org/10.1080/10426507.2018.1514405
2017年
Maintaining of the Green Fluorescence Emission of 9-Aminoanthracene for Bioimaging Applications
Yosuke Uchiyama, Ryo Watanabe, Takanori Kurotaki, Suguru Kuniya, Shinobu Kimura, Yukihiro Sawamura, Takemaru Ohtsuki, Yuichi Kikuchi, Hideyo Matsuzawa, Koji Uchiyama, Makoto Itakura, Fumitaka Kawakami, Hiroko Maruyama
ACS Omega, 2(7), 3371-3379, (2017)
https://doi.org/10.1021/acsomega.7b00711
2016年
E-Selective Wittig reactions using a nonstabilized phosphonium ylide bearing a phosphastibatriptycene skeleton with benzaldehydes under salt-free conditions
Yosuke Uchiyama, Takemaru Ohtsuki, Rikiya Murakami, Munenori Shibata, Jun Sugimoto.
Phosphorus, Sulfur, and Silicon and the Related Elements, 191 (11-12), 1523-1526 (2016)
https://doi.org/10.1080/10426507.2016.1212348
2015年
Imidazol-2-ylidene Reactivity towards Cyanocarbons
Anthony J. Arduengo, Joseph C. Calabrese, William J. Marshall, Jason W. Runyon, Christian Schiel, Christoph Schinnen, Matthias Tamm, Yosuke Uchiyama
Zeitschrift fur Anorganische und Allgemeine Chemie, 641(12-13), 2190-2198 (2015)
https://doi.org/10.1002/zaac.201500578
Cover Picture, 641(12-13), 2029 (2015) https://doi.org/10.1002/zaac.201590027
2014年
Synthesis, Crystal Structures, and Skeletal Inversion of Dithienodiphosphorines
Yosuke Uchiyama, Toshifumi Kawaguchi, Koichi Kuroda.
Heteroatom Chemistry, 25(5), 326-336 (2014)
https://doi.org/10.1002/hc.21163
The Zwitterionic Structure of the Parent Amidinium Tetrazolide and a Rare Tetrazole Ring-Opening Reaction
Yosuke Uchiyama, Joshua S. Dolphin, Richard L. Harlow, William J. Marshall, Anthony J. Arduengo III
Australian Journal of Chemistry, 67(3), 405-411 (2014)
https://www.publish.csiro.au/ch/ch13460