臨床生理学研究室

研究室について

研究テーマ

呼吸機能検査、超音波検査、心電図検査を応用し、様々な手法でより臨床に役立つ新たな検査法や測定意義について提案し、取り組んでいます。また、呼吸筋筋電図活動を測定することで、呼吸理学療法を効果的に行うためのエビデンス作りにも注力しています。

気流速度と換気量の変化がIOSの測定結果に与える影響について

Impulse Oscillometry System法（IOS法）では周波数特性を利用することで気道抵抗やリアクタンスなどの値を評価することが可能です。IOS法での測定は安静呼吸下で行え、かつ数回分の安静換気で終了します。呼吸機能検査施行時に、緊張等の影響で呼吸回数が通常の安静呼吸時よりも変化する場合があります。これら呼吸の状態の変化がIOS法の測定値に与える影響を検討し、臨床に役立てることを目的とした研究です。

メンバー

横場正典2
教授
横場　正典
YOKOBA
Masanori
1715923228822
講師
宇治橋　善勝
Yoshikatsu
Ujihashi

プロジェクト?研究業績

プロジェクト

研究業績

著書?論文

【論文】
  1. Yokoba M, Ichikawa T, Harada S, Shiomi K, Mikubo M, Ono M, Sonoda D, Satoh Y, Hanawa H, Naoki K and Katagiri M. Comparison of quantitative computed tomography, scintigraphy, and anatomical methods for prediction of postoperative FEV1 and DLCO. Effects of COPD status and resected lobes. J Thorac Dis. 12(10):5269-5280. 2020. doi: 10.21037/jtd-20-1280.
  2. Igawa S, Ono T, Kasajima M, Kusuhara S, Otani S, Fukui T, Yokoba M, Kubota M, Katagiri M, Mitsufuji H, Sasaki J, Naoki K. Real-world assessment of afatinib for patients with EGFR-positive non-small cell lung cancer. Invest New Drugs. 38(6):1906-1914. 2020. doi: 10.1007/s10637-020-00948-9.
  3. Fukui T, Hosotani S, Soda I, Ozawa T, Kusuhara S, Kakegawa MI, Kasajima M, Hiyoshi Y, Igawa S, Yokoba M, Mitsufuji H, Kubota M, Katagiri M, Sasaki J, Ishiyama H, Naoki K. Current status and progress of concurrent chemoradiotherapy in patients with locally advanced non-small cell lung cancer prior to the approval of durvalumab. Thorac Cancer. 11(14): 1005-14. 2020.
  4. Shirasawa M, Fukui T, Kusuhara S, Harada S, Nishinarita N, Hiyoshi Y, Ishihara M, Kasajima M, Igawa S, Yokoba M, Mitsufuji H, Kubota M, Katagiri M, Sasaki J and Naoki K. Prognostic differences between oligometastatic and polymetastatic extensive disease-small cell lung cancer. PLOS ONE. 14(4). 2020. e0214599. DOI: 10.1371.
  5. Fukui T, Ishihara M, Kasajima M, Hiyoshi Y, Nakahara Y, Otani S, Igawa S, Yokoba M, Mitsufuji H, Kubota M, Katagiri M, Sasaki J and Naoki K. Questionnaire survey on patient awareness of invasive rebiopsy in advanced non-small cell lung cancer. Thorac Cancer. 10(3): 501-7. 2019
  6. Yokoba M, Ichikawa T, Harada S, Naito M, Satoh Y and Katagiri M. Postoperative pulmonary function change according to the resected lobe: A 1-year follow-up for study of lobectomized patients. J Thorac Dis. 10 (12): 6891-902. 2018.
  7. Ichikawa T, Yokoba M, Kimura M, Shibuya M, Easton PA and Katagiri M. Genioglossus muscle activity during sniff and reverse sniff in healthy men. Exp Physiol. 103: 1656-65. 2018.
  8. Nakahara Y, Fukui T, Shirasawa M, Harada S, Kusuhara S, Takakura A, Yokoba M, Mitsufuji H, Kubota M, Katagiri M, Sasaki J, Masuda N, Inukai M, Sekiguchi T, Naoki K. Intracranial response to nivolumab in a patient with PD-L1 negative lung adenocarcinoma. Intern Med. 57 (21): 3149-52. 2018.
  9. Kurosaki Y, Imoto A, Kawakami F, Yokoba M, Takenaka T, Ichikawa T, Katagiri M, and Ishii N. Oxidative stress increases megalin expression in the renal proximal tubules during the normoalbuminuric stage of diabetes mellitus. Am J Physiol-Renal Physiol.  314 (3): F462-F470. 2018.
  10. Ishihara M, Igawa S, Sasaki J, Otani S, Fukui T, Ryuge S, Katono K, Hiyoshi Y, Kasajima M, Mitsufuji H, Kubota M, Yokoba M, Katagiri M, Sekiguchi A, Soda I, Ishiyama H, Hayakawa K, Masuda N. Evaluation of concurrent chemoradiotherapy for locally advanced NSCLC according to EGFR mutation status. Oncol Lett. 14 (1): 885-90. 2017.
  11. Tokura S, Akira M, Okuma T, Tazawa R, Arai T, Sugimoto C, Matsumuro A, Hirose M, Takada T, Nakata K, Ishii H, Kasahara Y, Hojo M, Ohkouchi S, Tsuchihashi Y, Yokoba M, Eda R, Nakayama H, Nei T, Morimoto K, Nasuhara Y, Ebina M, Ichiwata T, Tatsumi K, Yamaguchi E and Inoue Y. A Semiquantitative CT Grading System for Evaluating Therapeutic Response in Pulmonary Alveolar Proteinosis. Ann Am Thorac Soc. 14 (9): 1403-11. 2017.
  12. Kasajima M, Igawa S, Ishihara M, Otani S, Takakura A, Sasaki J, Yokoba M, Katagiri M, Masuda N. Correlation between the efficacy of amrubicin and the previous chemotherapy regimen for relapsed small cell lung cancer. Oncol Lett. 13 (3): 1719-24. 2017.
  13. Yokoba M, Hawes HG, Kieser MT, Katagiri M, Easton PA. Parasternal intercostal and diaphragm function during sleep. J Appl Physiol. 121 (1): 59-65. 2016.
  14. Otani S, Hamada A, Sasaki J, Wada M. Yamamoto M, Ryuge S, Takakura A, Fukui T, Yokoba M, Mitsufuji H, Toyooka I, Maki S, Kimura M, Hayashi N, Ishihara M, Kasajima M, Hiyoshi Y, Katono K, Asakuma M, Igawa S, Kubota M, Katagiri M, Saito H, Masuda N. Phase I and Pharmacokinetic Study of Erlotinib Administered in Combination With Amrubicin in Patients With Previously Treated, Advanced Non-Small Cell Lung Cancer. Am J Clin Oncol-Cancer Clin Trials. 38(45): 405-10.2015.
  15. Ichikawa T, Yokoba M, Ishii N, Takakura A, Kimura M, Masuda N, Easton PA, Katagiri M. Expiratory muscle activity and nasal expiratory pressure during reverse sniff. The Kitasato Medical Journal. 45(1):53-61. 2015. 
  16. Yokoba M, Katagiri M, Ichikawa T, Takakura A, Ishii N, Kurosaki Y, Yamada Y, Tsukushi T, Masuda N, Easton PA, Nishii Y, Okada Y, Abe T. Aminophylline increases respiratory muscle activities during hyperoxic hypercapnia in humans. Pulm Pharmacol Ther, 30C: 96-101. 2015.
  17. Tazawa R, Inoue Y, Arai T, Takada T, Kasahara Y, Hojo M, Ohkouchi S, Tsuchihashi Y, Yokoba M, Eda R, Nakayama H, Ishii H, Nei T, Morimoto K, Nasuhara Y, Ebina M, Akira M, Ichiwata T, Tatsumi K, Yamaguchi E, Nakata K. Duration of benefit in patients with autoimmune pulmonary alveolar proteinosis after inhaled GM-CSF therapy. Chest. 145(4):729-37. 2014.
  18. Ishii N, Carmines PK, Yokoba M, Imaizumi H, Ichikawa T, Ikenaga H, Kodera Y, Oh-Ishi M, Aoki Y, Maeda T, Takenaka T, Katagiri M. Angiotensin-Converting Enzyme Inhibition Curbs Tyrosine Nitration of Mitochondrial Proteins in the Renal Cortex during the Early Stage of Diabetes Mellitus in Rats. Clin Sci. 124(8): 543-52. 2013.
  19. Yokoba M, Ishii N, Ichikawa T, Wada M, Mitsufuji H, Kubota M, Masuda N, Katagiri M. Association of superior vena cava syndrome with sleep apnea: investigation using an impulse oscillometry system. International Journal of Clinical Medicine. 3(4): 270-5. 2012. 
  20. Wada M, Yamamoto M, Ryuge S, Nagashima Y, Hayashi N, Maki S, Otani S, Katono K, Takakura A, Yanaihara T, Igawa S, Yokoba M, Mitsufuji H, Kubota M, Katagiri M, Masuda N. Phase II study of S-1 monotherapy in patients with previously treated, advanced non-small-cell lung cancer. Cancer Chemother Pharmacol. 69(4):1005-11. 2012.
  21. Takakura A, Kurita A, Asahara T, Yokoba M, Yamamoto M, Ryuge S, Igawa S, Yasuzawa Y, Sasaki J, Kobayashi H, Masuda N. Rapid deconjugation of SN-38 glucuronide and adsorption of released free SN-38 by interstinal microorganisms in rat. Oncol lett. 3: 520-524. 2012.
  22. Ohashi K, Sato A, Takada T, Arai T, Kasahara Y, Hojo M, Nei T, Nakayama H,Motoi N, Urano S, Eda R, Yokoba M, Tsuchihashi Y, Ishii H, Ebina M, Yamaguchi E, Inoue Y, Nakata K, Tazawa R. Reduced GM-CSF autoantibody in improved lung of autoimmune pulmonary alveolar proteinosis. Eur Resp J. 39(3):777-80. 2012.
  23. Ohashi K, Sato A, Takada T, Arai T, Nei T, Kasahara Y, Motoi N, Hojo M, Urano S, Ishii H, Yokoba M, Eda R, Nakayama H, Nasuhara Y, Tsuchihashi Y, Kaneko C, Kanazawa H, Ebina M, Yamaguchi E, Kirchner J, Inoue Y, Nakata K, Tazawa R. Direct evidence that GM-CSF inhalation improves lung clearance in pulmonary alveolar proteinosis. Respir Med. 106 (2):284-93. 2012
  24. Easton PA, Hawes HG, Doig CJ, Johnson MW, Yokoba M, Wilde ER. Parasternal muscle activity decreases in severe COPD with salmeterol-fluticasone propionate. Chest 137(3): 558-65. 2010.


【著書】
  1. 横場正典： 第3章 呼吸不全の病態生理．臨床工学講座. 生体機能代行装置学　呼吸療法装置第2版，日本臨床工学技士教育施設協議会 監修，廣瀬稔?生駒俊和 編集，第２版，医歯薬出版株式会社，東京，61-80．2019.
  2. 横場正典：16章 呼吸機能検査，プレスチスモグラフィー，肺拡散能．Lange Textbookシリーズ レックナー呼吸器学 基礎から疾患までの包括的アプローチ，福地義之助，本間生夫 監訳，丸善出版，東京，143-50．2015 (翻訳).
  3. 横場正典：Ⅱ実践編 チーム医療の実際 ２.チーム医療の展開例 ６）インフルエンザの流行.インタープロフェッショナル?ヘルスケア‐実践チーム医療論　実際と教育プログラム-，水本清久、岡本牧人、石井邦雄、土本寛二／編著，初版，医歯薬出版株式会社，東京，215-9．2011.

学会発表

  1. Yokoba M, Ichikawa T, Harada S, Kusuhara S, Ozawa T, Fukui T, Igawa S, Mitsufuji H, Kubota M, Sasaki J, Naoki K, Satoh Y and Katagiri M: Lung expansion and alternation of low attenuation volume in lobectomized patients. European Respiratory Society Annual Congress 2020.9.7-9, Wein, Austria. (Eur. Respir. J. E-Poster# 3129, September 7-9 2020)
  2. Ichikawa T, Tajiri S, Yokoba M, Horimizu Y, Yamaguchi S, Kawakami A, Kimura M, Kondo T, Katagiri M and Toyokura M: Sniff nasal inspiratory pressure as a predictor of 1-year mortality after exacerbation of COPD. European Respiratory Society Annual Congress 2020.9.7-9, Wein, Austria. (Eur. Respir. J. E-Poster# 4744, September 7-9 2020)
  3. Yokoba M, Ichikawa T, Harada S, Fukui T, Igawa S, Mitsufuji H, Kubota M, Sasaki J, Naoki K, Sato Y and Katagiri M: Prediction of FEV1 and DLco in lung cancer patients undergoing lobectomy: Comparison between quantitative computed tomography, scintigraphy, and anatomy. European Respiratory Society Annual Congress 2019.9.30, Madrid, Spain. (Eur. Respir. J. Abstract number 3844, September 28-October 2 2019)
  4. 黒崎祥史，井本明美，横場正典，市川尊文，竹中恒夫，片桐真人，石井直仁：megalinの制御的膜内切断（RIP）が酸化ストレスによるmegalin発現の変動に及ぼす影響．第59回日本臨床化学会年次学術集会，2019.9.27-29，宮城県仙台市．(臨床化学，Vol.48, 補冊1号) (2019.9.20-9.27)
  5. 石井直仁，井本明美，黒崎祥史，池永秀樹，土筆智晶，小幡進，鈴木英明，横場正典，市川尊文，竹中恒夫，片桐真人，：腎症発症前糖尿病らっとの腎皮質におけるミトコンドリアの融合?分裂とマイトファジーについて．第59回日本臨床化学会年次学術集会，2019.9.28，宮城県仙台市．(臨床化学，Vol.48, 補冊1号) (2019.9.27-9.29)

特許