微生物応用化学研究室

発表論文

定期刊行誌掲載論文 (英文原著)

2024年

  1. Kimishima A, Matsui H, Takarabe Y, Honsho M, Wasuwanich P, Honma S, Terai J, Hanaki H, Asami Y.* Colistin potentiates the anti-bacterial activity of 5-O-mycaminosyltylonolide for some Gram-negative bacteria. BPB Reports in press
  2. Honma S, Kimishima A, Kato S, Horiuchi A, Hokari R, Honsho M, Kojima H, Tokiwa T, Sugawara A, Iwatsuki M, Araki Y, Takahashi T, Chinen T, Usui T, Ito K, Asami Y.* The isolation of sclerotinin A as an anti-malarial compound by utilization of a global secondary metabolism regulator, laeA gene. Bioorg. Med. Chem. Lett. in press
  3. Kimishima A, Nishitomi A, Kondo N, Honma S, Honsho M, Negami S, Maruyama S, Taguchi K, Matsui H, Hanaki H, Chinen T, Usui T, Ogasawara H, Asami Y.* Isolation of microorganisms from the feces of Kitasato Yakumo beef cattle as bioactive natural product producers. Biosci. Biotechnol. Biochem. in press
  4. Kimishima A, Nishitomi A, Tsuruoka I, Sakai K, Hokari R, Honsho M, Honma S, Ono Y, Kondo N, Tsutsumi H, Kikuchi Y, Tokiwa T, Kojima H, Higo M, Nonaka K, Inahashi Y, Iwatsuki M, Fuji S, Jun-Pil Jang, Jae-Hyuk Jang, Chinen T, Usui T, Asami Y.* Discovery of an anti-malarial compound, burnettiene A, with a multidrug-sensitive Saccharomyces cerevisiae screening system based on mitochondrial function inhibitory activity. Biosci. Biotechnol. Biochem. in press
  5. Kimishima A, Nishitomi A, Tsuruoka I, Honsho M, Negami S, Honma S, Sakai K, Tokiwa T, Kojima H, Nonaka K, Fuji S, Chinen T, Usui T, Asami Y.* Synthesis and biological evaluation of burnettiene A derivatives enabling discovery of novel fungicide candidates. J. Pestic. Sci. in press
  6. Takemoto K, Nakayama R, Fujimoto K, Suzuki Y, Takarabe Y, Honsho M, Kitahara S, Noguchi Y, Matsui H, Hirose T, Asami Y, Hidaka J, Sunazuka T, Hanaki H. In vitro and in vivo activities of KSP-1007, a broad-spectrum inhibitor of serine- and metallo-β-lactamases, in combination with meropenem against carbapenem-resistant Gram-negative bacteria. Antimicrob. Agents Chemother. 68, e01602-23 (2024).
  7. Honma S, Kimishima Aoi, Kimishima Atsushi, Honsho M, Kojima H, Tokiwa T, Nishitomi A, Kato S, Kondo N, Araki Y, Takahashi T, Chinen T, Usui T, Fuji S, Ito K, Asami Y.* Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitive Saccharomyces cerevisiae screening system and the introduction of a global secondary metabolism regulator, laeA gene. Biosci. Biotechnol. Biochem. 88, 824-829 (2024).
  8. Islam A. Abdelhakim, Futamura Y, Asami Y, Hanaki H, Kito N, Masuda S, Shibata A, Muranaka A, Koshino H, Shirasu K, Osada H, Ishikawa J, Takahashi S. Expression of Syo_1.56 SARP regulator unveils potent elasnin derivatives with antibacterial activity. J. Nat. Prod. 87, 1459-1470 (2024).
  9. Watanabe Y, Haneda T, Kimishima A, Kuwae A, Suga T, Suzuki T, Iwabuchi Y, Honsho M, Honma S, Iwatsuki M, Matsui H, Hanaki H, Kanoh N, Abe A, Asami Y,* Ōmura S.* PurA is the main target of aurodox, a type III secretion system inhibitor. Proc. Natl. Acad. Sci. USA. 2024, 121, e2322363121 Co-corresponding author
  10. Kimishima A, Suzuki Y, Kosaka S, Honsho M, Honma S, Tsutsumi H, Inahashi Y, Watanabe Y, Nakashima T,* Asami Y,* Iwatsuki M.* Binding mode-based physicochemical screening method using D-Ala-D-Ala silica gel and chemical modification approach to facilitate discovery of new macrolactams, banglactams A and B, from Nonomuraea bangladeshensis K18-0086. ACS Omega 9, 17415-17422 (2024). Co-corresponding author
  11. Wannawong T, Mhuantong W, Macharoen P, Niemhom N, Sitdhipol J, Chaiyawan N, Tanasupawa S, Suwannarach N, Asami Y, Kuncharoen N. Comparative genomics reveals insight into the phylogeny and habitat adaptation of novel Amycolatopsis species, an endophytic actinomycete associated with scab lesions on potato tubers. Frontiers in Plant Science 2024, doi.org/10.3389/fpls.2024.1346574
  12. Kikuchi Y, Yoshida M, Kuwae A, Asami Y, Inahashi Y, Abe A. Correlation between the spread of IMP-producing bacteria and the promoter strength of blaIMP genes. J. Antibiot. 77, 315-323 (2024).
  13. Kimishima A, Honsho M, Terai J, Wasuwanich P, Honma S, Matsui H, Hanaki H, Asami Y.* Efflux pump inhibitor, phenylalanine-arginine beta-naphthylamide analog potentiates the activity of 5-O-mycaminosyltylonolide for multi-drug resistant Pseudomonas aeruginosa. J. Antibiot. 77, 331-333(2024).
  14. Kimishima A,* Hagimoto D, Honsho M, Sakai K, Honma S, Fuji S, Iwatsuki M, Tokiwa T, Nonaka K, Chinen T, Usui T, Asami Y.* Total synthesis of fusaramin, enabling stereochemical elucidation, structure-activity relationship, and uncovering the hidden antimicrobial activity against plant pathogenic fungi. Org. Lett. 2024, 26, 3, 597-601. Co-corresponding author
  15. Kimishima A, Tsuruoka I, Tsutsumi H, Honsho M, Honma S, Sugamata M, Matsui H, Sakai K, Inahashi Y, Hanaki H, Asami Y.* A new tetronomycin analog, broad-spectrum and potent antibiotic against drug-resistant Gram-positive bacteria. Chem. Biodivers. 2024, e202301834
  16. Honsho M, Kimishima A, Ikeda A, Iwatsuki M, Nonaka K, Matsui H, Hanaki H, Asami Y,* Sunazuka T.* The potentiation activity of β-lactam by phomoidrides and oxasetin against Methicillin-resistant Staphylococcus aureus. J. Antibiot. 2024, doi: 10.1038/s41429-023-00691-2. Co-corresponding author

2023年

  1. Tahara A, Tani K, Wakatsuki M, Tokiwa T, Higo M, Nonaka K, Hirose T, Hokari R, Ishiyama A, Iwatsuki M, Watanabe Y, Honsho M, Asami Y, Matsui H, Sunazuka T, Hanaki H, Teruya T, Ishii T. A novel aromatic compound from the fungus Synnemellisia sp. FKR-0921. J. Antibiot. 76, 706-710 (2023).
  2. Kimishima A, Suzuki Y, Kosaka S, Honsho M, Honma S, Sakai K, Tsutsumi H, Inahashi Y, Watanabe Y, Iwatsuki M,* Asami Y,* Nakashima T.* Design and synthesis of D-Ala-D-Ala silica gel for a binding mode-based physicochemical screening method. ACS Omega 8, 39035-39040 (2023). *Co-corresponding author
  3. Kondo N, Kimishima A, Maruyama S, Honma S, Nishitomi A, Sakai K, Honsho M, Watanabe Y, Iwatsuki M, Asami Y.* Synthesis and insecticidal activity evaluation of potential insecticidal natural product borrelidin analogs toward new pesticides. ACS Agric. Sci. Technol. 3, 648-656 (2023). *Corresponding author [Selected as a cover page.]
  4. Kimishima A, Matsui H, Sakai K, Honsho M, Honma S, Sugamata M, Kondo N, Maruyama S, Wasuwanich P, Naher K, Arima N, Abe K, Hanaki H, Asami Y.* Overcoming native macrolide and acquired multidrug-resistant Pseudomonas aeruginosa with azithromycin and polymyxin B nonapeptide. BPB Reports 6, 141-143 (2023). *Corresponding author
  5. Awano Y, Tsutsumi H, Kikuchi Y, Kimishima A, Iwatsuki M, Asami Y, Inahashi Y. Emblestatin: a new peptide antibiotic from Embleya scabrispora K20-0267. J. Antibiot. 76, 592-597 (2023)
  6. Kimishima A, Negami S, Tsuruoka I, Tsutsumi H, Matsui H, Sugamata M, Kondo N, Honsho M, Sakai K, Honma S, Naher K, Watanabe Y, Iwatsuki M, Inahashi Y, Hanaki H, Asami Y.* Re-evaluation and a structure-activity relationship study for the selective anti-anaerobic bacterial activity of luminamicin toward target identification. ACS Infect. Dis. 9, 1602-1609 (2023) *Corresponding author
  7. Taba K, Honsho M, Asami Y, Iwasaki H, Nonaka K, Watanabe Y, Iwatsuki M, Matsui H, Hanaki H, Teruya T, Ishii T. Synergistic effect of secondary metabolites isolated from Pestalotiopsis sp. FKR0115 in overcoming β-lactam resistance in MRSA. J. Gen. Appl. Microbiol. doi 10.2323/jgam.2023.06.001
  8. Kimishima A, Sakai K, Honsho M, Matsui H, Wasuwanich P, Watanabe Y, Iwatsuki M, Sunazuka T, Arima N, Abe K, Hanaki H, Asami Y.* A　combination strategy of a semisynthetic macrolide, 5-O-mycaminosyltylonolide with polymyxin B nonapeptide for multi-drug resistance P. aeruginosa. J. Antibiot. 76, 499-501 (2023) *Corresponding author
  9. Kikuchi Y, Kawashima M, Iwatsuki M, Kimishima A, Tsutsumi H, Asami Y, Inahashi Y, Comprehensive analysis of biosynthetic gene clusters in bacteria and discovery of Tumebacillus as a potential producer of natural products. J. Antibiot. 76, 316-323 (2023).
  10. Kimishima A, Sakai K, Honsho M, Wasuwanich P, Matsui H, Watanabe Y, Iwatsuki M, Sunazuka T, Arima N, Abe K, Hanaki H, Asami Y.* An efflux pump deletion mutant enabling to discovery of a macrolide as an overlooked anti-P. aeruginosa active compound. J. Antibiot. 76, 301-303 (2023). *Corresponding author
  11. Kimishima A, Tsuruoka I, Kanto H, Tsutsumi H, Arima N, Sakai K, Sugamata M, Matsui H, Watanabe Y, Iwatsuki M, Honsho M, Naher K, Inahashi Y, Hanaki H, Asami Y.* Rediscovery of tetronomycin as a broad-spectrum and potent antibiotic against drug-resistant Gram-positive bacteria. ACS Omega 8, 11556-11563 (2023). *Corresponding author
  12. Kimishima A, Ono Y, Sakai Katsuyuki, Sakai Kazunari, Honsho M, Naher K, Tokiwa T, Kojima H, Higo M, Nonaka K, Fuji S, Iwatsuki M, Chinen T, Usui T, Asami Y.* A combination strategy of multidrug-sensitive budding yeast and chemical modifications enabling to find a new overlooked anti-fungal compound, sakurafusariene from in-house fractionated library. J. Agric. Food Chem. 71, 3219-3224 (2023). *Corresponding author
  13. Kondo N, Kimishima A, Maruyama S, Sato M, Yuge H, Ohta Y, Mota-Sanchez D, Wise JC, Watanabe Y, Sakai K, Iwatsuki M, Asami Y.* The establishment of a highly-sensitive insecticidal activity detection system using silkworm first instar larvae enables efficiently search for insecticide seed compounds. ACS Agric. Sci. Technol. 3, 278-286 (2023). *Corresponding author [Selected as a cover page.]
  14. Ikeda A, Ikegaya Y, Honsho M, Matsui H, Nonaka K, Ishii T, Asami Y, Hanaki H, Hirose T, Sunazuka T. A new selective inhibitor for IMP-1 metallo-β-lactamase, 3Z,5E-octa-3,5-diene-1,3,4-tricarboxylic acid-3,4-anhydride. Bioorg. Med. Chem. 78, 117109 (2023).

2022年

  1. Kimishima A, Ando H, Sennari G, Noguchi Y, Sekikawa S, Kojima T, Ohara M, Watanabe Y, Inahashi Y, Takada H, Sugawara A, Matsumaru T, Iwatsuki M, Hirose T, Sunazuka T. Chemical degradation-inspired total synthesis of the antibiotic macrodiolide, luminamicin. J. Am. Chem. Soc. 144, 23148-23157 (2022).
  2. Watanabe Y, Hachiya K, Ikeda A, Nonaka K, Higo M, Muramatsu R, Noguchi C, Honsho M, Asami Y, Inahashi Y, Hirose T, Matsui H, Sunazuka T, Hanaki H, Ishii T, Teruya T, Hokari R, Ishiyama A, Iwatsuki M. Koshidacins A and B, antiplasmodial cyclic tetrapeptides from the Okinawan fungus Pochonia boninensis FKR-0564. J. Nat. Prod. 85, 2641-2649 (2022).
  3. A new isomaneonene derivative from the red alga Laurencia cf. mariannensis. Ishii T, Tahara A, Taba K, Iwatsuki M, Honsho M, Asami Y, Nonaka K, Hanaki H, Teruya T. J. Asian. Nat. Prod. Res. 6,1-7 (2022).
  4. Kikuchi Y, Matsui H, Asami Y, Kuwae A, Inahashi Y, Hanaki H, Abe A. Landscape of blaNDM genes in Enterobacteriaceae. J. Antibiot. 75, 559-566 (2022).
  5. Kimishima A, Hagimoto D, Honsho M, Watanabe Y, Iwatsuki M, Tsutsumi H, Inahashi Y, Naher K, Sakai K, Kuwae A, Abe A, Asami Y.* Insights into the structure-activity relationship of a type III secretion system inhibitor, aurodox. Bioorg. Med. Chem. Lett. 69, 128779 (2022) *Corresponding author
  6. Kondo N, Sakai K, Kimishima A, Hokari R, Honsho M, Sato M, Naher K, Yuge H, Iwatsuki M, Nonaka K, Asami Y.* Confluenine G, a new compound from a basidiomycetous yeast Moesziomyces sp. FKI-9540 derived from the gut of a moth Acherontia lachesis (Lepidoptera, Sphingidae). Biosci. Biotechnol. Biochem. 86, 949-954 (2022) *Corresponding author
  7. Kobayashi C, Watanabe Y, Oshima M, Hirose T, Yamasaki M, Iwamoto M, Iwatsuki M, Asami Y, Kuramochi K, Wakae K, Aizaki H, Muramatsu M, Sureau C, Sunazuka T, Watashi K. Fungal secondary metabolite exophillic acid selectively inhibits the entry of hepatitis B and D viruses. Viruses 14, 764 (2022).
  8. Koike R, Watanabe Y, Kato K, Mikasa Y, Shimizu K, Nonaka K, Honsho M, Suga T, Hokari R, Ishiyama A, Asami Y, Iwatsuki M. Shikinefragalides A-D, new tricyclic macrolides produced by Stachybotryaceae sp. FKI-9632. J Antibiot. 75, 199-206 (2022)

2021年

  1. Unten Y, Murai M, Sakai K, Asami Y, Yamamoto T, Masuya T, Miyoshi H. Natural tetramic acids elicit multiple inhibitory actions against mitochondrial machineries presiding over oxidative phosphorylation. Biosci. Biotechnol. Biochem. 85, 2368-2377 (2021)
  2. Sakai K, Unten Y, Kimishima A, Nonaka K, Chinen T, Sakai K, Usui T, Shiomi K, Iwatsuki M, Murai M, Miyoshi H, Asami Y,* Ōmura S. Traminines A and B, produced by Fusarium concentricum, inhibit oxidative phosphorylation in Saccharomyces cerevisiae mitochondria. J. Ind. Microbiol. Biotechnol. (2021) kuab051. doi: 10.1093/jimb/kuab051. *Corresponding author This article is dedicated to the fond memory of Professor Arnold L. Demain.
  3. Sakai K, Iwatsuki M, Kaneta T, Kimishima A, Asami Y, Sunazuka T, Masuma R, Nonaka K. Sesquicillin F, a new insecticidal meroterpenoid produced by Mariannaea macrochlamydospora FKI-4735. J. Antibiot. 74, 817-820 (2021)
  4. Kanaida M, Kimishima A, Eguchi S, Iwatsuki M, Watanabe Y, Honsho M, Hirose T, Noguchi Y, Nonaka K, Sennari G, Matsui H, Kaito C, Hanaki H, Asami Y,* Sunazuka T*. Total syntheses and chemical biology studies of hymeglusin and fusarilactone A, novel circumventors of β-lactam drug resistance in Methicillin-Resistant Staphylococcus aureus. ChemMedChem. 16, 2106-2111 (2021) *Co-corresponding author
  5. Sakai K, Iwatsuki M, Iizuka M, Asami Y, Nonaka K, Masuma R, Takizawa M, Nakashima T, Tokiwa T, Shiomi K, Ōmura S. Aldsulfin, a novel unusual anti-mannheimiosis epithiodiketopiperazine antibiotic produced by Lasiodiplodia pseudotheobromae FKI-4499. J. Antibiot. 74, 363-369 (2021)

2020年

  1. Ouchi T, Watanabe Y, Nonaka K, Muramatsu R, Noguchi C, Tozawa M, Hokari R, Ishiyama A, Koike R, Matsui H, Asami Y, Inahashi Y, Ishii T, Teruya T, Iwatsuki M, Hanaki H, Ōmura S. Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021. J. Antibiot. 73, 365-371 (2020)
  2. Asami Y, Kim SO, Jang JP, Ko SK, Kim BY, Osada H, Jang, JH, Ahn JS. CRM646-A, a fungal metabolite, induces nucleus condensation by increasing Ca2+ levels in rat 3Y1 fibroblast cells. J. Microbiol. Biotechnol. 30, 31-37 (2020)
2019年以前
  1. Iwasaki H, Tokiwa T, Shiina M, Asami Y, Shiomi K, Ōmura S, Nonaka K. Metarhizium aciculare sp. nov. for euvesperins A and B producing Metarhizium strains. Mycoscience 60, 313-318 (2019)
  2. Sakai K, Unten Y, Iwatsuki M, Matsuo H, Fukasawa W, Hirose T, Chinen T, Nonaka K Nakashima T, Sunazuka T, Usui T, Murai M, Miyoshi H, Asami Y, Ōmura S, Shiomi K. Fusaramin, an antimitochondrial activity compound discovered using multi-drug sensitive Saccharomyces cerevisiae produced by Fusarium sp. J. Antibiot. 72, 645-652 (2019)
  3. Soung NK,* Kim HM,* Asami Y,* Kim DH, Cho Y, Naik R, Jang Y, Jang K, Han HJ, Ganipisetti SR, Cha-Molstad H, Hwang J, Lee KH, Ko SK, Jang JH, Ryoo IJ, Kwon YT, Lee KS, Osada H, Lee K, Kim BY, Ahn JS. Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition. Exp. Mol. Med. 51, 10 (2019) *Equal contribution
  4. Sakai K, Suga T, Iwatsuki M, Chinen T, Nonaka K, Usui T, Asami Y, Ōmura S, Shiomi K. Pestiocandin, a new papulacandin class antibiotic isolated from Pestalotiopsis humus. J. Antibiot. 71, 1301-1035 (2018)
  5. Sakai K, Hirose T, Iwatsuki M, Chinen T, Kimura T, Suga T, Nonaka K, Nakashima T, Sunazuka T, Usui T, Asami Y, Ōmura S, Shiomi K. Pestynol, an antifungal compound discovered using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-based Assay. J. Nat. Prod. 81, 1604-1609 (2018)
  6. Sakai K,* Asami Y,* Chiba T, Suga T, Nonaka K, Iwatsuki M, Ōmura S, Shiomi K. Oxoberkedienoic acid: a new octadienoic acid derivative discovered using a chemical screening system. J. Gen. Appl. Microbiol. 64, 136-138 (2018) *Equal contribution
  7. Watanabe Y,* Asami Y,* Narusawa S, Hashimoto S, Iwatsuki M, Nonaka K, Shinohara Y, Shiotsuki T, Ichimaru N, Miyoshi H, Ōmura S, Shiomi K. Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein expressing Saccharomyces cerevisiae. J. Antibiot. 71, 146-148 (2018) *Equal contribution
  8. Thanuphol P, Asami Y, Shiomi K, Wongnoppavich A, Tuchinda P, Soonthornchareonnon N. Marcanine G, a new cytotoxic 1-azaanthraquinone from the stem bark of Goniothalamus marcanii Craib. Nat. Prod. Res. 32, 682-1689 (2018)
  9. Watanabe Y, Suga T, Narusawa S, Iwatsuki M, Nonaka K, Nakashima T, Shinohara Y, Shiotuki T, Ichimaru N, Miyoshi H, Asami Y, Ōmura S, Shiomi K. Decatamaric acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae. J. Antibiot. 70, 395-399 (2017)
  10. Chiba T,* Asami Y,* Suga T, Watanabe Y, Nagai T, Momose, Nonaka K, Iwatsuki M, Ōmura S, Shiomi K. Herquline A, produced by Penicillium herquei FKI-7215, exhibits anti-influenza virus properties. Biosci. Biotechnol. Biochem. 81, 59-62 (2017) *Equal contribution
  11. Kimura T, Iwatsuki M, Asami Y, Ishiyama A, Hokari R, Otoguro K, Matsumoto A, Sato N, Shiomi K, Takahashi Y, Ōmura S, Nakashima T. Anti-trypanosomal compound, sagamilactam, a new polyene macrocyclic lactam from Actinomadura sp. K13-0306. J. Antibiot. 69, 818-824 (2016)
  12. Suga T, Shiina M, Asami Y, Iwatsuki M, Yamamoto T, Nonaka K, Masuma R, Matsui H, Hanaki H, Iwamoto S, Onodera H, Ōmura S, Shiomi K. Paraphaeosphaeride D and berkleasmin F, new circumventors of arbekacin resistance in MRSA, produced by Paraphaeosphaeria sp. TR-022. J. Antibiot. 69, 605-610 (2016)
  13. Shiina M, Suga T, Asami Y, Nonaka K, Iwatsuki M, Ōmura S, Shiomi K. Euvesperines A, B and PI-091 and B, new circumventors of arbekacin resistance in MRSA, produced by Metarhizium sp. FKI-7236. J. Antibiot. 69, 719-722 (2016)
  14. Nakashima T, Miyano R, Iwatsuki M, Shirahata T, Kimura T, Asami Y, Kobayashi Y, Shiomi K, Takahashi Y, Ōmura S. Iminimycin A, the new iminium metabolite produced by Streptomyces griseus OS-3601. J. Antibiot. 69, 611-615 (2016)
  15. Suga T,* Asami Y,* Hashimoto S, Nonaka K, Iwatsuki M, Nakashima T, Watanabe Y, Sugahara R, Shiotsuki T, Yamamoto T, Shinohara Y, Ichimaru N, Murai M, Miyoshi H, Ōmura S, Shiomi K. Trichopolyn VI, a new peptaibol: a potential candidate for the insecticide discovered by a screening system using recombinant Saccharomyces cerevisiae. J. Gen. Appl. Microbiol. 61, 82-87 (2015) *Equal contribution
  16. Suga T,* Asami Y,* Hashimoto S, Nonaka K, Iwatsuki M, Nakashima T, Sugahara R, Shiotsuki T, Yamamoto T, Shinohara Y, Ichimaru N, Murai M, Miyoshi H, Ōmura S, Shiomi K. Ascosteroside C, a new mitochondrial respiration inhibitor discovered by pesticidal screening using recombinant Saccharomyces cerevisiae. J. Antibiot. 68, 649-652 (2015) *Equal contribution
  17. Nonaka K, Chiba T, Suga T, Asami Y, Iwatsuki M, Masuma R, Ōmura S, Shiomi K.　Coculnol, a new penicillic acid produced by a co-culture of Fusarium solani FKI-6853 and Talaromyces sp. FKA-65. J. Antibiot. 68, 530-532 (2015)
  18. Sugawara A, Kubo M, Nakashima T, Hirose T, Tsunoda N, Yahagi K, Asami Y, Yamada T, Shiomi K, Takahashi Y, Ōmura S, Sunazuka T. Jietacins with potent nematocidal activity; efficient isolation of novel analogs and divergent total synthesis of jietacin A, B, C, and D. Tetrahedron 71, 2149-2157 (2015)
  19. Kim SO, Sakchaisri K, Asami Y, Ryoo IJ, Choo SJ, Yoo ID, Soung NK, Kim YS, Jang JH, Kim BY, Ahn JS. Illudins C2 and C3 Stimulate Lipolysis in 3T3-L1 Adipocytes and Suppress Adipogenesis in 3T3-L1 Preadipocytes. J. Nat. Prod. 77, 744-750 (2014)
  20. Jayasooriya, RG, Moon DO, Park SR, Choi YH, Asami Y, Kim MO, Jang JH, Kim BY, Ahn JS, Kim GY. Combined treatment with verrucarin A and tumor necrosis factor-α sensitizes apoptosis by overexpression of nuclear factor-kappaB-mediated Fas. Environ Toxicol Pharmacol. 36, 303-310 (2013)
  21. Moon DO, Asami Y, Kim MO, Jang JH, Kim BY, Ahn JS, Kim GY, Yun SG. Xestospongin C induces monocytic differentiation of HL60 cells through activation of the ERK pathway. Food Chem Toxicol. 55, 505-512 (2013)
  22. Kim SO, Sakchaisri K, Thimmegowda NR, Soung NK, Jang JH, Kim YS, Lee KS, Kwon YT, Asami Y, Ahn JS, Erikson RL, Kim BY. STK295900, a dual inhibitor of topoisomerase 1 and 2, induces G (2) arrest in the absence of DNA damage. PLoS One. 8, e53908 (2013)
  23. Jayasooriya RG, Moon DO, Yun SG, Choi YH, Asami Y, Kim MO, Jang JH, Kim BY, Ahn JS, Kim GY. Verrucarin A enhances TRAIL-induced apoptosis via NF-κB-mediated Fas overexpression. Food Chem Toxicol. 55, 1-7 (2013)
  24. Moon DO, Asami Y, Long H, Jang JH, Bae EY, Kim BY, Choi YH, Kang CH, Ahn JS, Kim GY. Verrucarin A sensitizes TRAIL-induced apoptosis via the upregulation of DR5 in an eIF2α/CHOP-dependent manner. Toxicol. In Vitro. 27, 257-63 (2013)
  25. Asami Y, Jang JH, Oh H, Sohn JH, Kim JW, Moon DO, Kwon O, Kawatani M, Osada H, Kim BY, Ahn JS. Violaceols function as actin inhibitors inducing cell shape elongation in fibroblast cells. Biosci. Biotechnol. Biochem. 76, 1431-1437 (2012)
  26. Asami Y, Jang JH, Soung NK, He L, Moon DO, Kim JW, Oh H, Muroi M, Osada H, Kim BY, Ahn JS. Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells. Bioorg. Med. Chem. 20, 3799-3806 (2012)
  27. Jang JP, Jang JH, Soung NK, Kim HM, Jeong SJ, Asami Y, Shin KS, Kim MR, Oh H, Kim BY, Ahn JS. Benzomalvin E, an indoleamine 2,3-dioxygenase inhibitor isolated from Penicillium sp. FN070315. J. Antibiot. 65, 215-217 (2012)
  28. Neff SA, Lee SU, Asami Y, Ahn JS, Oh H, Baltrusaitis J, Gloer JB, Wicklow DT. Aflaquinolones A-G: secondary metabolites from marine and fungicolous isolates of Aspergillus spp. J. Nat. Prod. 75, 464-472 (2012)
  29. Jang JH,* Asami Y,* Jang JP,* Kim SO, Moon DO, Shin KS, Hashizume D, Muroi M, Saito T, Oh H, Kim BY, Osada H, Ahn JS. Fusarisetin A, an acinar morphogenesis inhibitor from a soil fungus, Fusarium sp. FN080326. J. Am. Chem. Soc. 133, 6865-6867 (2011) *Equal contribution
  30. Lee SU, Asami Y, Lee D, Jang JH, Ahn JS, Oh H. Protuboxepins A and B and protubonines A and B from the marine-derived fungus Aspergillus sp. SF-5044. J. Nat. Prod. 74, 1284-1287 (2011)
  31. Asami Y, Horie R, Hamamoto H, Sekimizu K. Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources. BMC Pharmacol. 10, 7 (2010)
  32. Wang X, Nagase H, Watanabe T, Nobusue H, Suzuki T, Asami Y, Shinojima Y, Kawashima H, Takagi K, Mishra R, Igarashi J, Kimura M, Takayama T, Fukuda N, Sugiyama H. Inhibition of MMP-9 transcription and suppression of tumor metastasis by pyrrole-imidazole polyamide. Cancer Sci. 101, 759-766 (2010)
  33. Suzuki T, Asami Y,* Takahashi T, Wang X, Watanabe T, Bando T, Sugiyama H, Fukuda N, Nagase H*. Development of a molecule recognized promoter DNA sequence for inhibition of HER2 expression. J. Antibiot. 62, 339-341(2009) *Co-corresponding author
  34. Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S, Sugimoto Y, Osada H. Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus. Chembiochem 10, 920-928 (2009)
  35. Asami Y, Mori M, Koshino H, Sekiyama Y, Teruya T, Simizu S, Usui T, Osada H. A cell-based screening to detect inhibitors of BRAF signaling pathway. J. Antibiot. 62, 105-107 (2009)
  36. Takahashi T, Asami Y, Kitamura E, Suzuki T, Wang X, Igarashi J, Morohashi A, Shinojima Y, Kanou H, Saito K, Takasu T, Nagase H, Harada Y, Kuroda K, Watanabe T, Kumamoto S, Aoyama T, Matsumoto Y, Bando T, Sugiyama H, Yoshida-Noro C, Fukuda N, Hayashi N. Development of pyrrole-imidazole polyamide for specific regulation of human aurora kinase-A and -B gene expression. Chem. Biol. 15, 829-841 (2008)
  37. Takahashi T, Tamura M, Asami Y, Kitamura E, Saito K, Suzuki T, Takahashi SN, Matsumoto K, Sawada S, Yokoyama E, Takasu T. Novel wide-range quantitative nested real-time PCR assay for Mycobacterium tuberculosis DNA: development and methodology. J. Clin. Microbiol. 46, 1708-1715 (2008)
  38. Asami Y, Kakeya H, Komi Y, Kojima S, Nishikawa K, Beebe K, Neckers L, Osada H. Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation. Cancer Sci. 99, 1853-1858 (2008)
  39. Takahashi T, Tamura M, Asami Y, Kitamura E, Saito K, Suzuki T, Takahashi SN, Matsumoto K, Sawada S, Yokoyama E, Takasu T. Novel wide-range quantitative nested real-time PCR assay for Mycobacterium tuberculosis DNA: clinical application for diagnosis of tuberculous meningitis. J. Clin. Microbiol. 46, 1698-1707 (2008)
  40. Asami Y, Kakeya H, Okada G, Toi M, Osada H. RK-95113, a new angiogenesis inhibitor produced by Aspergillus fumigatus. J. Antibiot. 59, 724-728 (2006)
  41. Asami Y, Kakeya H, Onose R, Chang YH, Toi M, Osada H. RK-805, an endothelial cells growth inhibitor, produced by Neosartorya sp. Tetrahedron 60, 7085-7091 (2004)
  42. Asami Y, Ogura T, Otake N, Nishimura T, Xinsheng Y, Sakurai T, Nagasawa H, Sakuda S, Tatsuta K. Isolation and synthesis of a new bioactive ellagic acid derivative from Combretum yunnanensis. J. Nat. Prod. 66, 729-731 (2003)
  43. Hayashi Y, Shoji M, Yamaguchi J, Sato K, Yamaguchi S, Mukaiyama T, Sakai K, Asami Y, Kakeya H, Osada H. Asymmetric total synthesis of (-)-azaspirene, a novel angiogenesis inhibitor. J. Am. Chem. Soc. 124, 12078-12079 (2002)
  44. Asami Y, Kakeya H, Onose R, Yoshida A, Matsuzaki H, Osada H. Azaspirene: a novel angiogenesis inhibitor containing a 1-Oxa-7-azaspiro [4.4] non-2-ene-4,6-dione skeleton produced by the fungus Neosartoya sp. Org. Lett. 4, 2845-2848 (2002)

定期刊行誌掲載論文 (英文総説)

  1. Ōmura S, Asami Y, Crump A. Staurosporine: new lease of life for parent compound of today's novel and highly successful anti-cancer drugs. J. Antibiot. 71, 688-701 (2018)

著書

  1. 浅見行弘、長田裕之　ケミカルゲノミクスの実際　天然有機化合物を出発点にしたケミカルバイオロジー研究、半田 宏 (編集)、ケミカルバイオロジー?ケミカルゲノミク、大型本、シュプリンガー?フェアラーク東京、2005年12月8日
  2. Chinen T, Hamada K, Asami Y, Shiomi K, Hayashi Y, Usui T. Multidrug-sensitive Yeast Strains as Tools for Chemical Genetics. InTechOpen - Yeast - Biomedical Applications. Published: January 17th 2018. DOI: 10.5772/intechopen.70664

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