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Organic Chemistry: Laboratory of Organic Chemistry for Drug Development

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professor：Makino Kazuishi associate professor： Lecturer/Junior Associate Professor：Daisuke Yamamoto research associate：Masayoshi Koshizuka Kento Dousei assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

Our laboratory is focused on advancing catalytic organic reaction through the development of new strategies for the synthesis of biologically active natural products and lead compound for drug discovery. The goal of our group is to contribute creative solutions to fundamental problems in chemistry that impact society. We are developing new catalysts and achieve practical total synthesis of natural products with the aim of drug development through technological innovation. It targets various functional molecules such as sugar chains and peptide chains.
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Laboratory of Medicinal Chemistry

keyword：　Medicinal Chemistry; GPCR

professor：Hideaki FUjii associate professor：Kennosuke Itoh Lecturer/Junior Associate Professor： research associate：Shigeto Hirayama Fumika Karaki Takaaki Mizuguchi assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

Welcome to the Laboratory of Medicinal Chemistry !!

We design and synthesize new compounds to evaluate them to find novel drug candidates. Such research field is dealt with midicinal chemistry. Although medicinal chemistry is based on organic chemistry, it is a comprehensive and interdiscrlinary science, which rests on many scientific field like medical science, pharmacology, molecular biology, pharmacokinetics, pharmaceutical science, and so on. We also develop novel photochemical reactions.
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Laboratory of Synthetic Natural Products Chemistry

keyword：　Total synthesis, Organic synthetic chemistry, SAR study

professor：Tohru Nagamitsu associate professor：Masaki Ohtawa Lecturer/Junior Associate Professor： research associate：Shiho Arima Daiki Lee Junya Hirai assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

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Drug Discovery Information Science: Laboratory of Biomolecular Design

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professor：Mayuko Takeda-Shitaka associate professor： Lecturer/Junior Associate Professor： research associate：Yasuomi Kiyota Masaki Wakasugi Shinpei Kobayashi assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

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Laboratory of Physical Chemistry for Drug Design

keyword：　Drug development, drug design, computer, X-ray crystal structure analysis

professor：Nobutada Tanaka associate professor：Noriyuki Yamaotsu Lecturer/Junior Associate Professor： research associate：Izumi Nakagome Shin-ichiro Ozawa Tomoki Yoshida assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

professor：Nobutada Tanaka

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Pharmacology/Pharmacognosy: Laboratory of Pharmacology

keyword：　chronic pain, intractable depression, central nervous system disorders, electrophysiology, behavioral studies

professor：Mitsuo Tanabe associate professor： Lecturer/Junior Associate Professor：Yasuhito Naito Takashi Iwai research associate：Shun Watanabe Misa Oyama assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

Using behavioral, electrophysiological and biochemical approaches, we elucidate the pathophysiology of central nervous system diseases such as chronic pain, pruritus, depression and stress, to find crucial factors leading to the development of novel therapeutic agents.
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Laboratory of Molecular Pharmacology

keyword：　retinal blood vessel, neuro-glia-vascular unit, glaucoma, retinopathy

professor：Tsutomu Nakahara associate professor： Lecturer/Junior Associate Professor：Toshihide Kashihara research associate：Akane Morita Saori Deguchi assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

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Laboratory of Pharmacognosy

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professor：Yoshinori Kobayashi associate professor：Tatsuya Shirahata Lecturer/Junior Associate Professor： research associate：Huang Xuedan Shunsuke Nakamori Naruki Konishi assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

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Pharmaceutics/Analytical Chemistry: Laboratory of Pharmaceutics

keyword：　intestinal absorption, drug transporter, metabolic enzymes, drug-drug interaction, prediction of pharmacokinetics

professor：Kazuya Maeda associate professor： Lecturer/Junior Associate Professor：Tomoya Narawa research associate：Shuhei Takano Ryuto Tomabechi assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

Quantitative understanding of the pharmacokinetics of drugs to facilitate drug development and to realize the proper use of drugs in the clinics

“Biopharmaceutics”is the research field to understand the mechanisms that govern the drug movement inside the body after drugs are administered. The pharmacokinetics (PK) of drugs in the body is determined by multiple processes of so-called "ADME"; Absorption, Distribution, Metabolism, and Excretion. In recent years, it has been elucidated that the ADME properties of drugs are dominated not only by their simple physicochemical properties but also by the functions of various PK-related molecules (metabolic enzymes, transporters) in a drug-selective manner. In addition, the functions of these molecules are modified by multiple intrinsic and extrinsic factors such as genetic polymorphisms, drug-drug interactions and pathophysiological conditions. Finally, various functional modifications of each function results in the inter-individual differences in the pharmacokinetics of drugs and subsequently their pharmacological/toxicological effects.
　We are studying to clarify the factors controlling pharmacokinetics and their quantitative contributions, and to predict in vivo pharmacokinetics based on the results of in vitro experiments.

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Laboratory of Analytical Chemistry

keyword：　Innovative medicines, Analytical methodology, Liposome, Exosome (extracellular vesicles), Drug delivery, D-amino acids

professor：Kumiko Sakai-Kato associate professor：Toshihiko Sugiki Lecturer/Junior Associate Professor：Tetsuya Miyamoto research associate：Masae Sekine Yasuaki Saitoh assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

Analysis of drugs and biomolecules for drug development
Our team investigates the analytical techniques for quality control of drugs such as liposome drug products and peptide drugs. We also analyze the properties and physiological functions of biomolecules such as exosomes and D-amino acids.
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Hygiene/Health Science: Laboratory of Hygienic Chemistry

keyword：　Cell Death, Lipid peroxidation, GPx4

professor：Hirotaka Imai associate professor： Lecturer/Junior Associate Professor： research associate：Tomoko Koumura Masaki Matsuoka Syu Yasuda assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

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Laboratory of Public Health

keyword：　toxicology, methylmercury, metal, phytoremediation, autophagy, cellular response, anti-MeHg drug

professor：KIYONO, Masako associate professor：TAKANEZAWA, Yasukazu Lecturer/Junior Associate Professor：URAGUCHI, Shimpei research associate：NAKAMURA, Ryosuke OHSHIRO, Yuka assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

Lab alumni reunion (Feb., 2024)

Protecting Our Health from Toxic Substances in Daily Life

The Department of Public Health investigates the molecular mechanisms of metal toxicity, particularly methylmercury, aiming to protect our health from toxic metal toxicity and achieve better health.

We examine the biological responses to the metal toxicants using various biological materials as models, including mice, mammalian cells, Arabidopsis thaliana (model plant), and E. coli. We apply the approaches of molecular and cellular biology as well as analytical chemistry to track and regulate the behaviors of toxic metals in organisms.
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Biochemistry/Microbiology: Laboratory of Biochemistry

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professor：Mitsuru Okuwaki associate professor： Lecturer/Junior Associate Professor：Yoshio Shibagaki Naoyuki Iida research associate：Shoko Saito assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

Cell

Welcome to the website of the Laboratory of Biochemistry, School of Pharmacy, Kitasato University. Our laboratory is studying the molecular mechanisms of gene expression and signal transduction pathways. Gene expression program is tightly regulated by various extracellular stimuli and its misregulation causes human diseases such as cancer. We use various biochemical and cell biological techniques to tackle the mysteries of biology. If you are interested in the lab, feel free tocontact us!.
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Laboratory of Microbiology

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professor：Yun-Gi Kim associate professor： Lecturer/Junior Associate Professor：Takeshi Haneda Tsuyoshi Miki research associate：Masahiro Ito assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

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Laboratory of Microbial Chemistry

keyword：　microbial chemistry, drug discovery, hyperlipidemia, cancer, infectious diseases, bone-related diseases

professor：OHSHIRO Taichi associate professor： Lecturer/Junior Associate Professor：OHTE Satoshi KOBAYASHI Keisuke research associate：SHIGENO Satoru Elyza Aiman Azizah Nur assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

For many years, we have screened and searched for novel compounds from microbial resources using our original assay system, and have been conducting drug discovery and development.
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Other facilities: Radioisotope Research Laboratory

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professor： associate professor： Lecturer/Junior Associate Professor： research associate： assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

Ultraviolet rays in sunlight cause short- or long-term damage to the skin depending on the wavelength of UV light and how it is exposed, and induce diseases depending on the degree of damage and damage accumulation.
Our laboratory aims to elucidate the mechanisms of the phenomena and responses (cellular responses) that occur in cells exposed to ultraviolet rays, and to develop research that will be useful for the mitigation and treatment of skin disorders and diseases caused by ultraviolet rays.
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Analytical Unit for Organic Chemistry

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professor： associate professor： Lecturer/Junior Associate Professor： research associate： assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

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Analytical Unit for Biochemistry and Molecular Biology

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professor： associate professor： Lecturer/Junior Associate Professor： research associate： assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

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Laboratory Animal Research Center

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professor： associate professor： Lecturer/Junior Associate Professor： research associate： assistant： Director of Medicinal Plant Garden： Director General： Director： Head：

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Laboratories and Research Facilities

Laboratory of Organic Chemistry for Drug Development

Laboratory of Medicinal Chemistry

Laboratory of Synthetic Natural Products Chemistry

Laboratory of Biomolecular Design

Laboratory of Physical Chemistry for Drug Design

Laboratory of Pharmacology

Laboratory of Molecular Pharmacology

Laboratory of Pharmacognosy

Laboratory of Pharmaceutics

Laboratory of Analytical Chemistry

Analysis of drugs and biomolecules for drug development

Laboratory of Hygienic Chemistry

Laboratory of Public Health

Laboratory of Biochemistry

Laboratory of Microbiology

Laboratory of Microbial Chemistry

Radioisotope Research Laboratory

Analytical Unit for Organic Chemistry

Analytical Unit for Biochemistry and Molecular Biology

Laboratory Animal Research Center