1. TOP
  2. Laboratories
  3. Laboratories and Research Facilities
  4. Laboratory introduction

Laboratory introduction

Laboratory of Biochemistry

Japanese
Cell

Welcome to the website of the Laboratory of Biochemistry, School of Pharmacy, Kitasato University. Our laboratory is studying the molecular mechanisms of gene expression and signal transduction pathways. Gene expression program is tightly regulated by various extracellular stimuli and its misregulation causes human diseases such as cancer. We use various biochemical and cell biological techniques to tackle the mysteries of biology. If you are interested in the lab, feel free tocontact us!.

Laboratory News

  • 2025.04.02 HP1BP3 paper has been accepted in Epigenetics and Chromatin. The paper described the following three points: 
    HP1BP3 functions as a linker histones.
    The linker histone function of HP1BP3 is regulated by linker histone chaperones, TAF-I and NPM1. 
    ChIP-Seq analyses demonstrated that linker histone H1.2 and HP1BP3 show different chromatin binding specificities, which are regulated by linker histone chaperones.
  • JB cover
    2023.11.06 NPM1-LLPS paper was accepted in J Biochemistry. Regulation of NPM1 oligomer formation was found to be closely associated with its ability of liquid droplet formation.  NPM1 oligomer stability is regulated by its N-terminal and central acidic disordered regions. When the acidic nature increases by phosphorylation at the disordered regions, the oligomer stability of NPM1 decreases, which results in the formation of NPM1-liquid droplets with higher fluidity. This paper is accepted in J Biochemistry, and its Graphical Abstract was used as a cover image of the 2023 November issue. The image was created by a master course student, Moeka Sawafuji, in the lab.
  • 2023.03.03 NPM1-LLPS paper depositted on BioRxiv