生物系共有機器室

1. Definition of phosphatidylinositol 4,5-bisphosphate distribution by freeze-fracture replica labeling.
Tsuji T, Hasegawa J, Sasaki T, Fujimoto T.
J Cell Biol. 224. e202311067 (2025)

2. New insights into the regulation and roles of phosphatidylinositol 3,4-bisphosphate.
Hasegawa J*. (*: corresponding author)
J Biochem. 176. 339-345 (2024)

3. p53 ensures the normal behavior and modification of G1/S-specific histone H3.1 in the nucleus.
Oikawa T, Hasegawa J, Handa H, Ohnishi N, Onodera Y, Hashimoto A, Sasaki J, Sasaki T, Ueda K, Sabe H.
Life Sci Alliance. 7. e202402835 (2024)

4. Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity.
Tran DM, Yoshioka N, Bizen N, Mori-Ochiai Y, Yano M, Yanai S, Hasegawa J, Miyashita S, Hoshino M, Sasaki J, Sasaki T, Takebayashi H.
Dis Model Mech. 16. dmm050169 (2023)

5. Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration.
Benyair R, Giridharan SSP, Rivero-Ríos P, Hasegawa J, Bristow E, Eskelinen EL, Shmueli MD, Fishbain-Yoskovitz V, Merbl Y, Sharkey LM, Paulson HL, Hanson PI, Patnaik S, Al-Ramahi I, Botas J, Marugan J, Weisman LS
Autophagy Rep. 2. 2166722 (2023)

6. PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy.
Oe Y, Kakuda K, Yoshimura S, Hara N, Hasegawa J, Terawaki S, Kimura Y, Ikenaka K, Suetsugu S, Mochizuki H, Yoshimori T, Nakamura S
PLoS Genet. 18. e1010264 (2022)

7. Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics.
Kanemaru K, Shimozawa M, Kitamata M, Furuishi R, Kayano H, Sukawa Y, Chiba Y, Fukuyama T, Hasegawa J, Nakanishi H, Kishimoto T, Tsujita K, Tanaka K, Itoh T, Sasaki J, Sasaki T, Fukami K, Nakamura Y.
Nat. Commun. 13. 2347 (2022)

8. PIKFYVE-dependent regulation of MTORC1 and TFEB.
Hasegawa J, Inoki K, Weisman LS
Autophagy Rep. 1. 247-251 (2022)

9. PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity.
Hasegawa J*, Tokuda E, Yao Y, Sasaki T, Inoki K, Weisman LS*. (*: corresponding author)
Mol. Biol. Cell. 33. ar26 (2022)

10. A mass spectrometric method for in-depth profiling phosphoinositide regioisomers and their disease-associated regulation.
Morioka S, Nakanishi H, Yamamoto T, Hasegawa J, Tokuda E, Hikita T, Sakihara T, Kugii Y, Oneyama C, Yamazaki M, Suzuki A, Sasaki J, Sasaki T.
Nat. Commun. 13. 83 (2022)

11. A role of phosphatidylserine in the function of recycling endosomes.
Hasegawa J, Uchida Y, Mukai K, Lee S, Matsudaira T, Taguchi T.
Front Cell Dev Biol. 24. 9, 783857 (2021)

12. PI4P/PS countertransport by ORP10 at ER-endosome membrane contact sites regulates endosome fission.
Kawasaki A, Sakai A, Nakanishi H, Hasegawa J, Taguchi T, Sasaki J, Arai H, Sasaki T, Igarashi M, Nakatsu F.
J. Cell Biol. 221(1). e202103141 (2022)

13. SH3YL1 cooperates with ESCRT-I in the sorting and degradation of the EGF receptor.
Hasegawa J, Imen J, Yamamoto H, Tsujita K, Tokuda E, Shibata H, Maki M, Itoh T
J. Cell Sci. 132(19). Jcs229179 (2019)

14. ­­Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.
Al-Ramahi I, Giridharan SS, Chen Y, Patnaik S, Safren N, Hasagawa J, de Haro M, Gee A, Titus S, Jeong H, Clarke J, Krainc D, Zheng W, Irvine R, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan J.
eLife. 6. e29123 (2017)

15. Dysregulation of autophagy in melanocytes contributes to hypopigmented macules in tuberous sclerosis complex.
Yang F, Yang L, Wataya-Kaneda M, Hasegawa J, Yoshimori T, Tanemura A, Tsuruta D, Katayama I.
J Dermatol Sci. 89. 155-164 (2018)

16. Endosomal phosphatdylserine is critical for the YAP signalling pathway in proliferating cells.
Matsudaira T, Mukai K, Noguchi T, Hasegawa J, Hatta T, Iemura S, Natsume T, Miyamura N, Nishina H, Nakayama J, Semba K, Tomita T, Murata S, Arai H, Taguchi T.
Nat Commun. 8. 1246 (2017)

17. PI5P and PI(3,5)P2: Minor, but Essential Phosphoinositides.
Hasegawa J*, Strunk BS, Weisman LS. (*: corresponding author)
Cell Struct Funct. 42. 49-60 (2017)

18. Regulation of lysosomal phosphoinositide balance by INPP5E is essential for autophagosome-lysosome fusion.
Nakamura S, Hasegawa J, Yoshimori T.
Autophagy. 12. 2500-2501 (2016)

19. Autophagosome-lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome.
Hasegawa J, Iwamoto R, Otomo T, Nezu A, Hamasaki M, Yoshimori T.
EMBO J. 35. 1853-1867 (2016)

20. Selective autophagy: Lysophagy
Hasegawa J, Maejima I, Iwamoto R, Yoshimori T.
Methods. 75. 128-132 (2015)

21. Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer.
Tokuda E, Itoh T, Hasegawa J, Ijuin T, Takeuchi Y, Irino Y, Fukumoto M, Takenawa T.
Cancer Res. 74: 3054-3066 (2014)

22. Antagonistic regulation of F-BAR protein assemblies controls actin polymerization during podosome formation.
Tsujita K, Kondo A, Kurisu S, Hasegawa J, Itoh T, Takenawa T.
J. Cell Sci. 126: 2267-2278 (2013)

23. Mechanistic insights into the regulation of circular dorsal ruffle formation.
Itoh T, Hasegawa J.
J. Biochem. 153: 21-29 (2013)

24. ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5.
Hasegawa J, Tsujita K, Takenawa T, Itoh T.
Mol. Biol. Cell. 23: 2481-2489 (2012)

25. Quantification and visualization of phosphoinositides by quantum dot-labeled specific binding-domain probes.
Irino Y, Tokuda E, Hasegawa J, Itoh T, Takenawa T.
J. Lipid Res. 53: 810-819. (2012)

26. Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes.
Uchida Y*, Hasegawa J*, Chinnapen D, Inoue T, Okazaki S, Kato R, Wakatsuki S, Misaki R, Koike M, Uchiyama Y, Iemura SI, Natsume T, Kuwahara R, Nakagawa T, Nishikawa K, Mukai K, Miyoshi E, Taniguchi N, Sheff D, Lencer WI, Taguchi T, Arai H. (*: equal contribution)
Proc. Natl. Acad. Sci. U S A. 108: 15846-15851. (2011)

27. SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain.
Hasegawa J, Tokuda E, Tenno T, Tsujita K, Sawai H, Hiroaki H, Takenawa T, Itoh T.
J. Cell Biol. 193: 901-916 (2011)

28. Proteome of acidic phospholipid-binding proteins: spatial and temporal regulation of Coronin 1A by phosphoinositides.
Tsujita K, Itoh T, Kondo A, Oyama M, Kozuka-Hata H, Irino Y, Hasegawa J, Takenawa T.
J. Biol. Chem. 285: 6781-6789 (2010)

29. The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration.
Itoh T, Hasegawa J, Tsujita K, Kanaho Y, Takenawa T.
Sci. Signal. 2: ra52 (2009)

30. Identification of the positive regulatory and distinct core regions of promoters, and transcriptional regulation in three types of mouse phospholipid hydroperoxide glutathione peroxidase.
Imai H, Saito M, Kirai N, Hasegawa J, Konishi K, Hattori H, Nishimura M, Naito S, Nakagawa Y.
J. Biochem. 140: 573-590 (2006)