ロゴ
大学施設

RESEARCH

研究室紹介

分子構築学

キーワード:#人工酵素の設計合成 #貴金属化合物 #リン化合物

酵素モデル貴金属化合物の開拓合成、触媒機能の探究

この講座では新しい物質を作り出し、分析し、構造を決めて、物質の構造と性質の相関を解明することを目標にしています。そのため周期表のあらゆる元素を組み合わせて化合物をつくり、分析する手法と技術を磨いていきます。「独創的な方法を用いた新規化合物の合成」を目指して、人類の財産となる物質を生み出すという夢にチャレンジしています。

業績

2024

Selective recognition and reversible encapsulation of tetrameric alcohol clusters via hydrogen bonds using a perfluorinated dinuclear nickel(II) complex
Y. Habuka, H. Usui, M. Okawa, T. Shinohara, H. Yuge, Y. Mao, J. Gong, G. J. Richards, A. Hori
CrystEngComm 2024, 26, 3014-3020
https://doi.org/10.1039/D4CE00166D

Synthesis and π-Hole vs. π Effect of Pt(II) Complexes with Pentafluorophenyl and Phenyl-Substituted Bipyridines
A. Hori*, Y. Takeuchi, T. Kawasaki, N. Toyama, H. Yuge, T. Hiroi 
Crystals 2024, 14, 430
https://doi.org/10.3390/cryst14050430

Synthesis and Crystal Structures of Rhomb-Shaped Dimeric Pd(II) Complexes with Arylethynyl-Substituted 2,2'-Bipyridine through CH???π Interactions in the Crystalline States
A. Hori*, R. Ichisugi, D. Azegami, N. Toyama, H. Yuge 
Crystals 2024, 14, 255
https://doi.org/10.3390/cryst14030255

2023

Thermo-/Mechano-Chromic Chiral Coordination Dimer: Formation of Switchable and Metastable Discrete Structure through Chiral Self-Sorting
K. Takimoto*, T. Shimada, K. Nagura, J. P. Hill, T. Nakanishi, H. Yuge, S. Ishihara*, J. Labuta*, H. Sato*
J. Am. Chem. Soc. 2023, 145, 25160–25169. 
https://doi.org/10.1021/jacs.3c05866 (ChemRxiv)

Iron Pivalate Complexes Containing PNN Pincer Ligand: Synthesis and Application to Dehydrogenative Hydrosilane Coupling
M. Kamitani*, K. Kanemitsu, K. Yujiri, H. Yuge
Organometallics, 2023, 42, 1839–1848.
https://doi.org/10.1021/acs.organomet.3c00161

2022

Vibrational Circular Dichroism Spectroscopy toward Intercalation Compounds of Sodium Montmorillonite: Evidences for Molecular Packing of Enantiopure Monovalent Ir(III) Complexes within Interlayer Spaces
H. Sato*, K. Takimoto, A. Yamagishi, J. Yoshida, M. Hara
Appl. Clay Sci. 2022, 228, 106621.
https://doi.org/10.1016/j.clay.2022.106621

Clay Column Chromatography for Optical Resolution: A Series of Derivatized Amino Acids
A. Yamagishi*, S. Yamamoto, K. Takimoto, K. Tamura, M. Kamon, F. Sato, H. Sato*
Bull. Chem. Soc. Jpn. 2022, 95, 961–967. 
https://doi.org/10.1246/bcsj.20220077

Confluenine G, a new compound from a basidiomycetous yeast Moesziomyces sp. FKI-9540 derived from the gut of a moth Acherontia lachesis (Lepidoptera, Sphingidae)
N. Kondo, K. Sakai, A. Kimishima, R. Hokari, M. Honsho, M. Sato, K. Naher, H. Yuge, M. Iwatsuki, K. Nonaka, Y. Asami*
Biosci., Biotechnol., Biochem., 2022, 86, 949–954.
https://doi.org/10.1093/bbb/zbac062

2021

Efficient Synthesis of Cyclotriphosphazene Tripodal Tridentate Ligand via the Copper(I)-Template Method
K. Kajiyama*, J. Iwanami, H. Yuge
Heterocycles, 2021, 102, 2363–2371.
https://doi.org/10.3987/COM-21-14540

Chiroptical switching behavior of heteroleptic ruthenium complexes bearing acetylacetonato and tropolonato ligands
J. Yoshida*, K. Yamazaki, K. Tateyama, H. Yuge, H. Sato
Dalton Trans., 2021, 50, 14611–14617.
https://doi.org/10.1039/D1DT02592A

Chemically Robust and Readily Available Quinoline-based PNN Iron Complexes: Application in C-H Borylation of Arenes
M. Kamitani*
Chem. Commun. 2021, 57, 13246–13258.
https://doi.org/10.1039/D1CC04877E
 

2020

Crystal structures and charge distribution of partially-fluorinated β-diketonate copper(II) complexes based on Hirshfeld surface analysis and DFT calculations
A. Hori*, H. Kobayashi, G. Sakamoto, H. Yuge
Polyhedron 2020, 192, 114825 
https://doi.org/10.1016/j.poly.2020.114825

Stabilization of oxidized ruthenium complexes by adsorption on clay minerals
J. Yoshida*, K. Tateyama, Y. Kasahara, H. Yuge
Appl. Clay Sci. 2020, 199, 105869
https://doi.org/10.1016/j.clay.2020.105869

Hemisphere and Distance-Dependent Steric Analysis of PNN Iron Pincer Complexes Using SambVca 2.1 and Its Influence on Alkene Hydrosilylation
M. Kamitani*, K. Yujiri, H. Yuge
Organometallics 2020, 39, 3535-3539
https://doi.org/10.1021/acs.organomet.0c00512

Visualizing the helical stacking of octahedral metallomesogens with a chiral core
G. Watanabe*, H. Watanabe, K. Suzuki, H. Yuge, S. Yoshida, T. Mandai, S. Yoneda, H. Sato, M. Hara, J. Yoshida* 
Chem. Commun. 2020, 56, 12134-12137
https://doi.org/10.1039/d0cc05930g

Hexagonal ordering of racemic Ni(ii) complexes in the interlayer space of a clay mineral
J. Yoshida*, K. Tateyama, H. Yuge, M. Hara*
Chem. Commun. 2020, 56, 10670-10673
https://doi.org/10.1039/d0cc04977h

Optically Active 10,10'-spirobi[10H-phenoxasilin]-1,1'-diol:  Synthesis, Structure, and Application of its Phosphoramidite Derivative to Palladium-catalyzed Asymmetric Allylic Amination
K. Kajiyama*, T. Nishi, S. Noda, S. Horiuchi, H. Yuge
Chem. Lett. 2020, 49, 550-552
https://doi.org/10.1246/cl.200070

Enhanced and Heteromolecular Guest Encapsulation in Nonporous Crystals of a Perfluorinated Triketonato Dinuclear Copper Complex
Y. Ikumura, Y. Habuka, S. Sakai, T. Shinohara, H. Yuge, I. I. Rzeznicka, A. Hori*
Chem. - Eur. J. 2020, 26, 5051-5060
https://doi.org/10.1002/chem.201905740

2019

Tris(tropolonato)ruthenium as a hub for connecting π-conjugated systems
J. Yoshida*, K. Tateyama, H. Yuge 
Dalton Trans. 2020, 49, 2102-2111.
http://doi.org/10.1039/c9dt04860j

Competing Forces in the Self-Assembly of Amide-Functionalized Discotic Mesogens
J. Yoshida*, K. J. A. Bozek, J. R. Thompson, V. E. Williams*
Soft Matter 2019, 15, 10035–10044.
https://doi.org/10.1039/c9sm01435g

Development of Activator-Free Iron Pincer Complexes for Alkene Hydrosilylation and Elucidation of Its Activation Mechanism
K. Kamitani*, H. Kusaka, H. Yuge
Chem. Lett. 2019, 48, 1196–1198.
https://doi.org/10.1246/cl.190521

Iron-Catalyzed Versatile and Efficient C(sp2)-H Borylation
M. Kamitani*, H. Kusaka, H. Yuge
Chem. Lett. 2019, 48, 1196–1198.
https://doi.org/10.1246/cl.190345

Synthesis, Structures and Co-Crystallizations of Perfluorophenyl Substituted β-Diketone and Triketone Compounds
T. Kusakawa, S. Sakai, K. Nakajima, H. Yuge, I. I. Rzeznicka, A. Hori
Crystals 2019, 9, 175.
https://doi.org/10.3390/cryst9030175

Crystal Structure and Structural Transformation of [(CH3)3NH]2[CuZn(CN)5]
K. Miyahara, J. Yoshida, H. Yuge, S.-I. Nishikiori*
Z. Anorg. Allg. Chem. 2019, 645, 466–471.
https://doi.org/10.1002/zaac.201800461

2018

Comprehensive Understanding of Host- and Guest-Dependent Helix Inversion in Chiral Nematic Liquid Crystals: Experimental and Molecular Dynamics Simulation Study
J. Yoshida*, S. Tamura, K. Hoshino, H. Yuge, H. Sato, A. Yamazaki, S. Yoneda, G. Watanabe*
J. Phys. Chem. B 2018, 122, 10615–10626.
https://doi.org/10.1021/acs.jpcb.8b07653

Facile Entry to Iron Complexes Supported by Quinoline-Based PNN Pincer Ligand
M. Kamitani*, H. Kusaka, T. Toriyabe, H. Yuge
Bull. Chem. Soc. Jpn. 2018, 91, 1429–1435.
https://doi.org/10.1246/bcsj.20180124

Dihydride Iron Complex Bearing a Silyl-Tethered Cyclopentadienyl Ligand
M. Kamitani*, Y. Nishiguchi, M. Itazaki, H. Nakazawa*
Bull. Chem. Soc. Jpn. 2018, 91, 588–593.
https://doi.org/10.1246/bcsj.20170403

Left- and Right-Circularly Polarized Light-Sensing Based on Colored and Mechano-Responsive Chiral Nematic Liquid Crystals
J. Yoshida*, S. Tamura, H. Yuge, G. Watanabe*
Soft Matter 2018, 14, 27–30.
https://doi.org/10.1039/c7sm01975k

2017

Poly[bis-(tri-methyl-ammonium) [hexa-μ-cyanido-cadmium(II)dicopper(I)]]
S. Nishikiori, J. YoshidaH. Yuge
IUCr Data 2017, 2, x171771.
https://doi.org/10.1107/S2414314617017710

Polyhydrides of Sc, Zr and Hf and Their Proposed Formation
T. Kurogi, M. Kamitani, P. J. Carroll, D. J. Mindiola*
Isr. J. Chem. 2017, 57, 999–1009.
https://doi.org/10.1002/ijch.201700062

Room-Temperature Ring-Opening of Quinoline, Isoquinoline, and Pyridine with Low-Valent Titanium
S.-Y. Baek, T. Kurogi, D. Kang, M. Kamitani, S. Kwon, D. P. Solowey, C.-H. Chen, M. Pink, P. J. Carroll, D. J. Mindiola*, M.-H. Baik*
J. Am. Chem. Soc. 2017, 139, 12804–12814.
https://doi.org/10.1021/jacs.7b07433

Syntheses and Characterisation of Novel N/O Trispirocyclic Cyclotriphosphazenes as Ligands for Endotopic Metal-Binding Complexes
K. Kajiyama*, J. Iwanami, Y. Fukushima, Y. Takahashi, H. Yuge
Inorg. Chem. Commun. 2017, 82, 52–56.
https://doi.org/10.1016/j.inoche.2017.04.030

“Colored” Inorganic Dopants for Inducing Liquid Crystal Chiral Nematic and Blue Phases: Monitoring of Dopant–host Interaction by Raman Spectroscopy
J. Yoshida*, S. Tamura, G. Watanabe*, Y. Kasahara, H. Yuge
Chem. Commun. 2017, 53, 5103–5106.
https://doi.org/10.1039/C7CC01920C

Improvement of Molecular Dynamics Simulation Method Applied to Nematics Doped with Racemic Metal Complexes
G. Watanabe*, A. Yamazaki, J. Yoshida
Mol. Cryst. Liq. Cryst. 2017, 647, 235–243.
https://doi.org/10.1080/15421406.2017.1289602

Enhancement of the Helical Twisting Power of a Ruthenium Complex by the Introduction of an Achiral Bulky Unit
J. Yoshida*, K. Kuwahara, S. Tamura, H. Yuge, G. Watanabe
Mol. Cryst. Liq. Cryst. 2017, 647, 179–185.
https://doi.org/10.1080/15421406.2017.1289586

Reactivity Studies of a Zirconium Methylidene Complex: Group Transfer and Methylenation Reactions
T. Kurogi, M. Kamitani, B. C. Manor, P. J. Carroll, D. J. Mindiola*
Organometallics 2017, 36, 74–79.
https://doi.org/10.1021/acs.organomet.6b00594

Development of New Carbon Resources: Production of Important Chemicals from Algal Residue
S. Yamaguchi, Y. Kawada, H. Yuge, K. Tanaka, S. Imamura
Sci. Rep. 2017, 7, 855.
https://doi.org/10.1038/s41598-017-00979-y

嵩高い金属錯体を用いたキラル液晶の構造研究
吉田 純, 渡辺 豪, 佐藤久子
EKISHO(液晶学会誌) 2017, 21, 105–112.
https://iap-jp.org/jlcs/paper/Paper/detail?pdf=21-2_105.pdf&&year=2017&month=4

Long-Range Intramolecular Electronic Communication in a Trinuclear Ruthenium Tropolonate Complex
J. Yoshida*, K. Kuwahara, K. Suzuki, H. Yuge
Inorg. Chem. 2017, 56, 1846–1856.
https://doi.org/10.1021/acs.inorgchem.6b02249

Direct C-H Functionalization of Methane by Homogeneous Catalysis
M. Kamitani*
J. Synth. Org. Chem Jpn. 2017, 75, 1290–1291.
https://doi.org/10.5059/yukigoseikyokaishi.75.1290

2016

Molecular Dynamics Approach for Predicting Helical Twisting Powers of Metal Complex Dopants in Nematic Solvents
G. Watanabe*, J. Yoshida*
J. Phys. Chem. B 2016, 120, 6858–6864.
https://doi.org/10.1021/acs.jpcb.6b04669

Chiral HPLC Separation, Absolute Structural Elucidation, and Determination of Stereochemical Stability of trans-Bis[2-(2-Pyridinyl)aminophenolato] Cyclotriphosphazene
K. Kajiyama*, Y. Setone, K. Aoyagi, H. Yuge
Chirality 2016, 28, 556–561.
https://doi.org/10.1002/chir.22612

Synthesis of Vinylphosphines and Unsymmetric Diphosphines: Iron-Catalyzed Selective Hydrophosphination Reaction of Alkynes and Vinylphosphines with Secondary Phosphines
M. Itazaki*, S. Katsube, M. Kamitani, H. Nakazawa*
Chem. Commun. 2016, 52, 3163–3166.
https://doi.org/10.1039/c5cc10185a

2015

Cyclo-P3 Complexes of Vanadium: Redox Properties and Origin of the 31P NMR Chemical Shift
B. Pinter, K. T. Smith, M. Kamitani, E. M. Zolnhofer, B. L. Tran, S. Fortier, M. Pink, G. Wu, B. C. Manor, K. Meyer, M.-H. Baik*, D. J. Mindiola*
J. Am. Chem. Soc. 2015, 137, 15247–15261.
https://doi.org/10.1021/jacs.5b10074

Phosphinoalkylidene and -alkylidyne Complexes of Titanium: Intermolecular C-H Bond Activation and Dehydrogenation Reactions
M. Kamitani, B. Pinter, K. Searles, M. G. Crestani, A. Hickey, B. C. Manor, P. J. Carroll, D. J. Mindiola*
J. Am. Chem. Soc. 2015, 137, 11872–11875.
https://doi.org/10.1021/jacs.5b06973

Thermal Activation of Solid-State Molybdenum Halide Clusters with an Octahedral Cluster Framework and their Application to Catalytic Synthesis of 3-Methylpyridine from Piperidine and Methanol
S. Kamiguchi*, R. Kajio, H. Yamada, H. Yuge, K. Okumura, H. Iida, S. Nagashima, T. Chihara
Bull. Chem. Soc., Jpn. 2015, 88, 1116–1122.
https://doi.org/10.1246/bcsj.20150055

Effects of Auxiliary Ligands of Pd(II) Dimers on Induction of Chiral Nematic Phases: Chirality Inversion and the Photo-Responsive Structural Change
K. Tamura, J. Yoshida, M. Taniguchi, T. Kitazawa, A. Yamagishi, H. Sato*
Dalton Trans. 2015, 44, 3209–3215.
https://doi.org/10.1039/c4dt02812k

2014

Bis(acetylacetonato)bis(pyrazolato)ruthenate(iii) as a Redox-Active Scorpionate Ligand
J. Yoshida*, K. Sugawara, H. Yuge, J. Okabayashi
Dalton Trans. 2014, 43, 16066–16073.
https://doi.org/10.1039/c4dt02331e

Three p-xylene-solvated pseudopolymorphs of bis[1,3-bis(pentafluorophenyl) propane-1,3-dionato]copper(II)
A. Hori*, K. Nakajima, H. Yuge
Acta Crystallogr., Sect. C 2014, 70, 960–964.
https://doi.org/10.1107/S2053229614020294

Guest-adjusted encapsulation and thermal studies of non-porous mononuclear Cu(II) coordination complexes through electrostatic interactions induced by fluorine substitution
A. Hori*, K. Nakajima, Y. Akimoto, K. Naganuma, H. Yuge
CrystEngComm 2014, 16, 8805–8817.
https://doi.org/10.1039/C4CE01243G

Dimeric Tetrathiafulvalene Linked to pseudo-ortho-[2.2]paracyclophane: Chiral Electrochromic Properties and Use as a Chiral Dopant
K. Kobayakawa, M. Hasegawa*, H. Sasaki, J. Endo, H. Matsuzawa, K. Sako, J. Yoshida, Y. Mazaki
Chem. Asian J. 2014, 9, 2751–2754.
https://doi.org/10.1002/asia.201402667

Mixed-Valence Dinuclear Ruthenium Complex Composed of Ru(II)-Acetylide and Ru(III)-Tropolonato Units: Acetylide–vinylidene Interconversion in Solution and Solid State
J. Yoshida*, K. Kuwahara, H. Yuge
J. Organomet. Chem. 2014, 756, 19–26.
https://doi.org/10.1016/j.jorganchem.2014.01.018

2013

A Porous Coordination Polymer with a Fourfold Interpenetrating β-Hydroquinone Framework Constructed from Bis(dibenzoylmethanato) cobalt(II) and Tridentate Quaterpyridine Ligand
J. Yoshida*, S.-I. Nishikiori, H. Yuge
J. Coord. Chem. 2013, 66, 4344–4354.
https://doi.org/10.1080/00958972.2013.867027

Aroylspirophosphoranes Bearing Two Naphth-1,8-Diyl-8-Oxy Groups: Synthesis, Crystal Structure, and np(Oapical)→π(CO) Charge Transfer Interaction
K. Kajiyama*, S. Fujimori, D. Yasuoka, T. Otsuka, T. K. Miyamoto
Tetrahedron 2013, 69, 9155–9160.
https://doi.org/10.1016/j.tet.2013.08.004

Tris(β-Diketonato) Ru(III) Complexes as Chiral Dopants for Nematic Liquid Crystals: The Effect of the Molecular Structure on the Helical Twisting Power
J. Yoshida*, G. Watanabe, K. Kakizawa, Y. Kawabata, H. Yuge
Inorg. Chem. 2013, 52, 11042–11050.
https://doi.org/10.1021/ic401240f

Stereoselective Synthesis of trans N/O Dispirocyclic Cyclotriphosphazenes Based on the Steric Demands of the Constrained 2-Pyridyl Group
K. Kajiyama*, M. Suzuki, M. Kojima, Y. Setone
Inorg. Chem. Commun. 2013, 35, 330–332.
https://doi.org/10.1016/j.inoche.2013.07.016

Bis(3-Cyano-Pentane-2,4-Dionato) Co(II) as a Linear Building Block for Coordination Polymers: Combinations with Two Polypyridines
J. Yoshida*, S.-I. Nishikiori, H. Yuge
J. Coord. Chem. 2013, 66, 2191–2200.
https://doi.org/10.1080/00958972.2013.800865

Three Polymorphic CdII Coordination Polymers Obtained from the Solution and Mechanochemical Reactions of 3-Cyanopentane-2,4-Dione with CdII Acetate
J. Yoshida*, S.-I. Nishikiori*, R. Kuroda, H. Yuge
Chem. Eur. J. 2013, 19, 3451–3457.
https://doi.org/10.1002/chem.201203728

Synthetic Strategy for a New Series of Oxo-Centered Tricobalt Complexes with Mixed Bridging Ligands of Acetate and Pyrazolate Anions
J. Yoshida*, S. Kondo, H. Yuge
Dalton Trans. 2013, 42, 2406–2413.
https://doi.org/10.1039/c2dt31988h

2011

The effect of Cl · · · π interactions on the conformations of 4-chloro-5-(2-phenoxyethoxy)phthalonitrile and 4-chloro-5-[2-(pentafluorophenoxy)ethoxy]phthalonitrile
A. Hori*, Y. Inoue, Y. Huge
Acta Crystallogr., Sect. C 2011, 67, o154–o156.
https://doi.org/10.1107/S0108270111008675

Radical Addition Reaction of Bis(naphth-1,8-Diyl-8-Oxy)hydrophosphorane to Olefins
K. Kajiyama*, D. Itou, Y. Hazama, Y. Yamamoto, T. K. Miyamoto
Heteroat. Chem. 2011, 22, 538–544.
https://doi.org/10.1002/hc.20719

Structural Transformation of Pyridinium Iodide Proceeding in the Solid State
J. Yoshida*, J. Fuchiwaki, S.-I. Nishikiori
CrystEngComm 2011, 13, 4635–4640.
https://doi.org/10.1039/C1CE05193H