Laboratory of Public Health
Laboratory of Public Health
Japanese
Lab alumni reunion (Feb., 2024)
Protecting Our Health from Toxic Substances in Daily Life
The Department of Public Health investigates the molecular mechanisms of metal toxicity, particularly methylmercury, aiming to protect our health from toxic metal toxicity and achieve better health.
We examine the biological responses to the metal toxicants using various biological materials as models, including mice, mammalian cells, Arabidopsis thaliana (model plant), and E. coli. We apply the approaches of molecular and cellular biology as well as analytical chemistry to track and regulate the behaviors of toxic metals in organisms.
Research Achievements
Effects of chemical forms of gadolinium on the spleen in mice after single intravenous administration
Ryosuke Nakamura,Yasukazu Takanezawa,Yuka Ohshiro,Shimpei Uraguchi,Masako Kiyono.
Biochemistry and Biophysics Reports, 29 :101217 (2022)
ガドリニウム化合物がマウスの脾臓に影響することを示しました。
p62/sequestosome 1 attenuates methylmercury-induced endoplasmic reticulum stress in mouse embryonic fibroblasts
Yasukazu Takanezawa,Ryosuke Nakamura,Takuro Sugimoto,Yuka Ohshiro,Shimpei Uraguchi,Masako Kiyono.
Toxicology Letters, 353 :93-99 (2021)
Development of affinity bead-based in vitro metal-ligand binding assay reveals dominant cadmium affinity of thiol-rich small peptides phytochelatins beyond glutathione
Shimpei Uraguchi,Kenichiro Nagai,Fumii Naruse,Yuto Otsuka,Yuka Ohshiro,Ryosuke Nakamura,Yasukazu Takanezawa,Masako Kiyono.
Metallomics : Integrated Biometal Science, 13 (12) :mfab068 (2021)
Cadmium transport activity of four mercury transporters (MerC, MerE, MerF and MerT) and effects of the periplasmic mercury-binding protein MerP on Mer-dependent cadmium uptake
Yuka Ohshiro,Shimpei Uraguchi,Ryosuke Nakamura,Yasukazu Takanezawa,Masako Kiyono.
FEMS Microbiology Letters, 367 (21) :fnaa177 (2020)
Stable expression of bacterial transporter ArsB attached to SNARE molecule enhances arsenic accumulation in Arabidopsis
Yusuke Deromachi,Shimpei Uraguchi,Masako Kiyono,Kazuhiro Kuga,Kohji Nishimura,Masa H Sato,Tomoko Hirano.
Plant Signaling & Behavior, 15 (11) :1802553 (2020)
Selection of agar reagents for medium solidification Is a critical factor for metal(loid) sensitivity and ionomic profiles of Arabidopsis thaliana
Shimpei Uraguchi,Yuka Ohshiro,Yuto Otsuka,Hikari Tsukioka,Nene Yoneyama,Haruka Sato,Momoko Hirakawa,Ryosuke Nakamura,Yasukazu Takanezawa,Masako Kiyono.
Frontiers in Plant Science, 11 :503 (2020)
https://doi.org/10.3389/fpls.2020.00503
植物に対する有害金属の毒性試験を実施する際には，培地に添加する寒天試薬の夾雑イオンの影響を考慮する必要性を提示しました。