公衆衛生学教室
公衆衛生学教室
English
教室の同窓会にて （2024年2月）
身の回りの有害物質から私たちの健康をまもる
公衆衛生学教室では，メチル水銀を中心とした有害金属による毒性の分子メカニズムの解明，そして有害金属毒性から私たちの健康をまもるための応用指向の研究をおこなっています。
マウス，培養細胞（哺乳類），シロイヌナズナ（モデル植物），大腸菌と様々な生物材料をモデルに，毒物に対する生体応答を解析します。分子生物学?細胞生物学的手法に加えて，ICP発光分析や水銀分析計などの機器分析の手法を用いた研究が特徴です。
業績
Phenylmercury stress induces root tip swelling through auxin homeostasis disruption
Shimpei Uraguchi, Masakazu Sato, Chihiro Hagai, Momoko Hirakawa, Kotomi Ogawa, Miyu Odagiri, Haruka Sato, Ayaka Ohmori, Yuka Ohshiro, Ryosuke Nakamura, Yasukazu Takanezawa, Masako Kiyono.
Plant Molecular Biology, 115 :8 (2025)
https://doi.org/10.1007/s11103-024-01538-6
A resilient mutualistic interaction between cucumber mosaic virus and its natural host to adapt to an excess zinc environment and drought stress.
Midori Tabara, Shimpei Uraguchi, Masako Kiyono, Izumi Watanabe, Atsushi Takeda, Hideki Takahashi, Toshiyuki Fukuhara.
Journal of Plant Research, 137 :1151-1164 (2024)
https://doi.org/10.1007/s10265-024-01573-w
東京農工大学，東北大学，立命館大学との共同研究で，植物の亜鉛栄養状態とウィルスの共生が環境ストレス応答に及ぼす相互作用を明らかとしました。北里大では亜鉛の定量分析で貢献しました。
Oleanolic acid-3-glucoside, a synthetic oleanane-type saponin, ameliorates methylmercury-induced dysfunction of synaptic transmission in mice
Ryosuke?Nakamura,?Takashi?Iwai,?Yasukazu?Takanezawa,?Tatsuya?Shirahata,?Naruki?Konishi,?Yuka?Ohshiro,?Shimpei?Uraguchi,?Mitsuo?Tanabe,?Yoshinori?Kobayashi,?Kenji?Sakamoto,?Tsutomu?Nakahara,?Megumi?Yamamoto,?Masako?Kiyono.
Toxicology, 506 :153867 (2024)
https://doi.org/10.1016/j.tox.2024.153867
Conversion of methylmercury into inorganic mercury via organomercurial lyase (MerB) activates autophagy and aggresome formation
Yasukazu Takanezawa, Kouhei Ishikawa, Shunsuke Nakayama, Ryosuke Nakamura, Yuka Ohshiro, Shimpei Uraguchi, Masako Kiyono.
Scientific reports, 13 :19958 (2023)
https://doi.org/10.1038/s41598-023-47110-y
Molecular Toxicology of Methylmercury and Phytoremediation of Toxic Metals for Human Health
Masako Kiyono, Yuka Ohshiro, Ryosuke Nakamura, Shimpei Uraguchi, Yasukazu Takanezawa.
BPB Reports, 6 :126-132 (2023)
https://doi.org/10.1248/bpbreports.6.4_126
Inhibition of p38 Mitogen-Activated Protein Kinases Attenuates Methylmercury Toxicity in SH-SY5Y Neuroblastoma Cells
Yasukazu Takanezawa, Kazuma Sakai, Shunsuke Nakayama, Ryosuke Nakamura, Yuka Ohshiro, Shimpei Uraguchi, Masako Kiyono.
Biological and Pharmaceutical Bulletin, 46 :1203-1210 (2023)
https://doi.org/10.1248/bpb.b23-00014
Gadolinium-based contrast agents suppress adipocyte differentiation in 3T3-L1 cells
Yasukazu Takanezawa, Ryosuke Nakamura, Yuka Ohshiro, Shimpei Uraguchi, Masako Kiyono.
Toxicology Letters, 383 :196-203 (2023)
https://doi.org/10.1016/j.toxlet.2023.07.003
Root cell-type specific expressions of bacterial mercury transporter MerC and plant SNARE SYP121 fusion protein differentially affect cadmium accumulation patterns of Arabidopsis
Shimpei Uraguchi, Yuka Ohshiro, Kaede Abe, Yuta Tsuchiya, Ryosuke Nakamura, Yasukazu Takanezawa, Masako Kiyono.
Soil Science and Plant Nutrition, 69 :294-302 (2023)
https://doi.org/10.1080/00380768.2023.2234396
Proteasome and p62/SQSTM1 are involved in methylmercury toxicity mitigation in mouse embryonic fibroblast cells
Yasukazu Takanezawa, Ryosuke Nakamura, Yuka Ohshiro, Shimpei Uraguchi, Masako Kiyono.
Journal of Toxicological Sciences, 48 :355-361 (2023)
https://doi.org/10.2131/jts.48.355