Laboratory of Microbial Chemistry

Celludinone C, a new dihydroisobenzofuran isolated from Talaromyces cellulolyticus BF-0307.

Seki R, Nagai K, Kobayashi K, Shigeno S, Shirahata T, Kobayashi Y, Ohshiro T, Tomoda H..
J Antibiot.,  :in press (2024)

Total syntheses of mavintramycin A and its structural analog, cytosaminomycin C, and evaluation of their antibacterial activities against Mycobacterium avium and Mycobacterium intracellulare.

Satoh H, Lee D, Arima S, Hosoda K, Shigeno S, Tomoda H, Ohshiro T, Nagamitsu T..
Tetrahedron, 168 :134299 (2024)
https://www.sciencedirect.com/science/article/abs/pii/S0040402024004800

Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase.

Nur EAA, Kobayashi K, Tejima R, Katada Y, Tomoda H, Ohshiro T..
J Antibiot., 77 :837-841 (2024)
https://pubmed.ncbi.nlm.nih.gov/39385005/

Catalindoles A-C, brominated indole alkaloids from a starfish Thromidia catalai feeding on Theonella sponges

Matsuta R, Shigeno S, Ohshiro T, Ueda M, Takada K.
Fish Sci., 90 :787-793 (2024)
https://link.springer.com/article/10.1007/s12562-024-01803-z

The new seriniquinone glycoside by biological transformation using the deep sea-derived bacterium Bacillus licheniformis KDM612

Okamura R, Kikuchi K, Taniguchi A, Nagai K, Seki R, Ohte S, Ohshiro T, Ando M, Tanaka T, Fukuda T.
J Antibiot., 77 :515-521 (2024)
https://pubmed.ncbi.nlm.nih.gov/38773230/

Paranazzamides A and B, new cyclic dipeptides containing a C7-prenylated tryptophan, produced by pathogenic reptile fungi Paranannizziopsis sp. UH-21.

Kobayashi K, Tejima R, Nagai K, Seki R, Hosoya T, Une Y, Shigeno S, Tomoda H, Ohshiro T.
J Antibiot., 77 :403-411 (2024)
https://pubmed.ncbi.nlm.nih.gov/38750250/

New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239.

Shigeno S, Kadowaki M, Nagai K, Hosoda K, Terahara T, Nishimura T, Hasegawa N, Tomoda H, Ohshiro T.
J Antibiot., 77 :265-271 (2024)
https://pubmed.ncbi.nlm.nih.gov/38531967/

Mavintramycin A is a promising antibiotic for treating Mycobacterium avium complex infectious disease

Hosoda K, Koyama N, Shigeno S, Nishimura T, Hasegawa N, Kanamoto A, Ohshiro T, Tomoda H.
Antimicrob Agents Chemother., 68 :e0091723 (2024)
https://pubmed.ncbi.nlm.nih.gov/38334410/

Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity

Nagai K, Kobayashi K, Miyake R, Sato Y, Seki R, Fukuda T, Yagi A, Uchida R, Ohshiro T, Tomoda H.
J Antibiot., 77 :214-220 (2024)
https://pubmed.ncbi.nlm.nih.gov/38267575/

Total synthesis of tanzawaic acid A.

Tanaka K, Suzuki S, Lee D, Arima S, Ohte S, Ohshiro T, Uchida R, Tomoda H, Nagamitsu T.
Tetrahedron, 143 :133556 (2023)
https://www.sciencedirect.com/science/article/pii/S0040402023003587