Laboratory of Microbial Chemistry
Laboratory of Microbial Chemistry
Japanese
For many years, we have screened and searched for novel compounds from microbial resources using our original assay system, and have been conducting drug discovery and development.
Research Achievements
Raman Imaging of an Amphotericin B Potentiator in Single-Cell Saccharomyces cerevisiae
Miyake R, Ando M, Kobayashi K, Nagai K, Ohshiro T, Tomoda H, Takeyama H..
J Phys Chem B., 129 :5720-5727 (2025)
https://pubmed.ncbi.nlm.nih.gov/40446163/
Nectriatides with no antifungal activity bind to ergosterol and potentiate the antifungal activity of amphotericin B against Candida albicans
Kobayashi K, Miyake R, Nagai K, Sato Y, Seki R, Sakai-Kato K, Nishimura S, Ohshiro T, Tomoda H..
BioRxiv, : (2025)
https://www.biorxiv.org/content/10.1101/2025.02.04.636370v1
Streptomyces haneummycinicus sp. nov., a new antibiotic-producing actinomycete isolated from marine sediment
Uemura M, Hamada M, Hirano S, Kobayashi K, Ohshiro T, Tsubouchi T, Kobayashi T, Terahara T..
Int J Syst Evol Microbiol., 75 :accepted (2025)
https://pubmed.ncbi.nlm.nih.gov/40354190/
Catalytic Enantioconvergent Alkylation Reactions That Construct Chiral Quaternary Carbon Centers and Tune C(sp3)-C(sp2) Bond Rotation
Sohail M, Kobayashi K, Tomoda H, Ohshiro T, Tanaka F..
Chemistry, 31 :e202500140 (2025)
https://pubmed.ncbi.nlm.nih.gov/39960741/
Evaluation of tirandamycins with selective activity against Enterococci in the silkworm infection model
Yagi A, Sato T, Kano C, Igari T, Oshima N, Ohte S, Ohshiro T, Uchida R.
J Antibiot., 78 :211-218 (2025)
https://pubmed.ncbi.nlm.nih.gov/39953284/
Celludinone C, a new dihydroisobenzofuran isolated from Talaromyces cellulolyticus BF-0307.
Seki R, Nagai K, Kobayashi K, Shigeno S, Shirahata T, Kobayashi Y, Ohshiro T, Tomoda H.
J Antibiot., 78 :26-34 (2025)
https://pubmed.ncbi.nlm.nih.gov/39543335/
Total syntheses of mavintramycin A and its structural analog, cytosaminomycin C, and evaluation of their antibacterial activities against Mycobacterium avium and Mycobacterium intracellulare.
Satoh H, Lee D, Arima S, Hosoda K, Shigeno S, Tomoda H, Ohshiro T, Nagamitsu T.
Tetrahedron, 168 :134299 (2024)
https://www.sciencedirect.com/science/article/abs/pii/S0040402024004800
Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase.
Nur EAA, Kobayashi K, Tejima R, Katada Y, Tomoda H, Ohshiro T.
J Antibiot., 77 :837-841 (2024)
https://pubmed.ncbi.nlm.nih.gov/39385005/
Catalindoles A-C, brominated indole alkaloids from a starfish Thromidia catalai feeding on Theonella sponges
Matsuta R, Shigeno S, Ohshiro T, Ueda M, Takada K.
Fish Sci., 90 :787-793 (2024)
https://link.springer.com/article/10.1007/s12562-024-01803-z
The new seriniquinone glycoside by biological transformation using the deep sea-derived bacterium Bacillus licheniformis KDM612
Okamura R, Kikuchi K, Taniguchi A, Nagai K, Seki R, Ohte S, Ohshiro T, Ando M, Tanaka T, Fukuda T.
J Antibiot., 77 :515-521 (2024)
https://pubmed.ncbi.nlm.nih.gov/38773230/