微生物薬品製造学教室
微生物薬品製造学教室
English
私たちは、微生物が生産する物質から新しい有用な天然化合物をみつけ、その働きを調べています。現在、動脈硬化、脂肪肝、肥満、結核、多剤耐性菌、がんや骨などに関する創薬研究が進行中です。新しい医薬品開発をみすえた我々の微生物資源からの創薬研究は、研究者だけでなく薬剤師を目指す人にも大いに役立つと思います。
業績
Evaluation of tirandamycins with selective activity against Enterococci in the silkworm infection model
Yagi A, Sato T, Kano C, Igari T, Oshima N, Ohte S, Ohshiro T, Uchida R.
J Antibiot., :accepted (2025)
Celludinone C, a new dihydroisobenzofuran isolated from Talaromyces cellulolyticus BF-0307.
Seki R, Nagai K, Kobayashi K, Shigeno S, Shirahata T, Kobayashi Y, Ohshiro T, Tomoda H.
J Antibiot., 78 :26-34 (2025)
https://pubmed.ncbi.nlm.nih.gov/39543335/
Total syntheses of mavintramycin A and its structural analog, cytosaminomycin C, and evaluation of their antibacterial activities against Mycobacterium avium and Mycobacterium intracellulare.
Satoh H, Lee D, Arima S, Hosoda K, Shigeno S, Tomoda H, Ohshiro T, Nagamitsu T.
Tetrahedron, 168 :134299 (2024)
https://www.sciencedirect.com/science/article/abs/pii/S0040402024004800
Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase.
Nur EAA, Kobayashi K, Tejima R, Katada Y, Tomoda H, Ohshiro T.
J Antibiot., 77 :837-841 (2024)
https://pubmed.ncbi.nlm.nih.gov/39385005/
Catalindoles A-C, brominated indole alkaloids from a starfish Thromidia catalai feeding on Theonella sponges
Matsuta R, Shigeno S, Ohshiro T, Ueda M, Takada K.
Fish Sci., 90 :787-793 (2024)
https://link.springer.com/article/10.1007/s12562-024-01803-z
The new seriniquinone glycoside by biological transformation using the deep sea-derived bacterium Bacillus licheniformis KDM612
Okamura R, Kikuchi K, Taniguchi A, Nagai K, Seki R, Ohte S, Ohshiro T, Ando M, Tanaka T, Fukuda T.
J Antibiot., 77 :515-521 (2024)
https://pubmed.ncbi.nlm.nih.gov/38773230/
Paranazzamides A and B, new cyclic dipeptides containing a C7-prenylated tryptophan, produced by pathogenic reptile fungi Paranannizziopsis sp. UH-21.
Kobayashi K, Tejima R, Nagai K, Seki R, Hosoya T, Une Y, Shigeno S, Tomoda H, Ohshiro T.
J Antibiot., 77 :403-411 (2024)
https://pubmed.ncbi.nlm.nih.gov/38750250/
New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239.
Shigeno S, Kadowaki M, Nagai K, Hosoda K, Terahara T, Nishimura T, Hasegawa N, Tomoda H, Ohshiro T.
J Antibiot., 77 :265-271 (2024)
https://pubmed.ncbi.nlm.nih.gov/38531967/
Mavintramycin A is a promising antibiotic for treating Mycobacterium avium complex infectious disease
Hosoda K, Koyama N, Shigeno S, Nishimura T, Hasegawa N, Kanamoto A, Ohshiro T, Tomoda H.
Antimicrob Agents Chemother., 68 :e0091723 (2024)
https://pubmed.ncbi.nlm.nih.gov/38334410/
Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity
Nagai K, Kobayashi K, Miyake R, Sato Y, Seki R, Fukuda T, Yagi A, Uchida R, Ohshiro T, Tomoda H.
J Antibiot., 77 :214-220 (2024)
https://pubmed.ncbi.nlm.nih.gov/38267575/