微生物薬品製造学教室
微生物薬品製造学教室
English
私たちは、微生物が生産する物質から新しい有用な天然化合物をみつけ、その働きを調べています。現在、動脈硬化、脂肪肝、肥満、結核、多剤耐性菌、がんや骨などに関する創薬研究が進行中です。新しい医薬品開発をみすえた我々の微生物資源からの創薬研究は、研究者だけでなく薬剤師を目指す人にも大いに役立つと思います。
業績
Catalindoles A-C, brominated indole alkaloids from a starfish Thromidia catalai feeding on Theonella sponges
Matsuta R, Shigeno S, Ohshiro T, Ueda M, Takada K.
Fish Sci., accepted (2024)
https://link.springer.com/article/10.1007/s12562-024-01803-z
The new seriniquinone glycoside by biological transformation using the deep sea-derived bacterium Bacillus licheniformis KDM612
Okamura R, Kikuchi K, Taniguchi A, Nagai K, Seki R, Ohte S, Ohshiro T, Ando M, Tanaka T, Fukuda T.
J Antibiot., in press (2024)
https://pubmed.ncbi.nlm.nih.gov/38773230/
Paranazzamides A and B, new cyclic dipeptides containing a C7-prenylated tryptophan, produced by pathogenic reptile fungi Paranannizziopsis sp. UH-21.
Kobayashi K, Tejima R, Nagai K, Seki R, Hosoya T, Une Y, Shigeno S, Tomoda H, Ohshiro T.
J Antibiot., 77 :403-411 (2024)
https://pubmed.ncbi.nlm.nih.gov/38750250/
New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239.
Shigeno S, Kadowaki M, Nagai K, Hosoda K, Terahara T, Nishimura T, Hasegawa N, Tomoda H, Ohshiro T.
J Antibiot., 77 :265-271 (2024)
https://pubmed.ncbi.nlm.nih.gov/38531967/
Mavintramycin A is a promising antibiotic for treating Mycobacterium avium complex infectious disease
Hosoda K, Koyama N, Shigeno S, Nishimura T, Hasegawa N, Kanamoto A, Ohshiro T, Tomoda H.
Antimicrob Agents Chemother., 68 :e0091723 (2024)
https://pubmed.ncbi.nlm.nih.gov/38334410/
Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity
Nagai K, Kobayashi K, Miyake R, Sato Y, Seki R, Fukuda T, Yagi A, Uchida R, Ohshiro T, Tomoda H.
J Antibiot., 77 :214-220 (2024)
https://pubmed.ncbi.nlm.nih.gov/38267575/
Total synthesis of tanzawaic acid A.
Tanaka K, Suzuki S, Lee D, Arima S, Ohte S, Ohshiro T, Uchida R, Tomoda H, Nagamitsu T.
Tetrahedron, 143 :133556 (2023)
https://www.sciencedirect.com/science/article/pii/S0040402023003587
Haneummycin, a new 22-membered macrolide lactam antibiotic, produced by marine-derived Streptomyces sp. KM77-8
Uemura M, Kobayashi K, Sato N, Nagai K, Seki R, Kamio M, Fukuda T, Tsubouchi T, Tomoda H, Ohshiro T, Kobayashi T, Terahara T.
J Antibiot., 76 :650-657 (2023)
https://pubmed.ncbi.nlm.nih.gov/37726436/
Astaxanthin Attenuates Nonalcoholic Steatohepatitis with Downregulation of Osteoprotegerin in Ovariectomized Mice Fed Choline-Deficient High-Fat Diet.
Zhao M, Ma L, Honda T, Kato A, Ohshiro T, Yokoyama S, Yamamoto K, Ito T, Imai N, Ishizu Y, Nakamura M, Kawashima H, Tsuji NM, Ishigami M, Fujishiro M.
Dig Dis Sci., 68 :155-168 (2023)
https://pubmed.ncbi.nlm.nih.gov/35397697/
Screening for microbial potentiators of neutral lipid degradation in CHO-K1 cells.
Nur EAA, Kobayashi K, Ohte S, Tomoda H,?Ohshiro T.
Drug Discov Ther.?, 16 :273-279 (2022)
https://pubmed.ncbi.nlm.nih.gov/36450503/