Laboratory of Molecular Pharmacology

2025 年

 3)
YAP activation in Müller cells alleviates oxidative stress in the rat retina after intravitreal injection with methylglyoxal.
Kashihara T, Yasaki M, Okuyama Y, Murayama A, Morita A, Nakahara T.
J Pharmacol Sci. 2025 Apr;157(4):219-228.
doi: 10.1016/j.jphs.2025.02.005.

 2)
Pharmacological depletion of pericytes induces diabetic retinopathy-like abnormal blood vessels in neonatal rat retina.
Otsuka K, Morita A, Kashihara T, Nakahara T.
Exp Eye Res. 2025 Feb;251:110243.
doi: 10.1016/j.exer.2025.110243. 

 1)
Repeated treatment with VEGF receptor inhibitors induces phenotypic changes in endothelial cells and pericytes in the rat retina.
Nakano A, Kawada T, Morita A, Nakahara T.
Microvasc Res. 2025 Jan;157:104756.
doi: 10.1016/j.mvr.2024.104756. 
 

2024 年

6)
YAP activation in Müller cells protects against NMDA-induced retinal ganglion cell injury by regulating Bcl-xL expression.
Kashihara T, Morita Y, Hatta M, Inoue S, Suzuki Y, Morita A, Nakahara T.
Front Pharmacol. 2024 Aug 6;15:1446521.
doi: 10.3389/fphar.2024.1446521. 

5)
Oleanolic acid-3-glucoside, a synthetic oleanane-type saponin, ameliorates methylmercury-induced dysfunction of synaptic transmission in mice.
Nakamura R, Iwai T, Takanezawa Y, Shirahata T, Konishi N, Ohshiro Y, Uraguchi S, Tanabe M, Kobayashi Y, Sakamoto K, Nakahara T, Yamamoto M, Kiyono M.
Toxicology. 2024 Aug;506:153867. doi: 10.1016/j.tox.2024.153867. 

 4)
Role of monocarboxylate transporters in AMPK-mediated protection against excitotoxic injury in the rat retina.
Yamagishi H, Kirai N, Morita A, Kashihara T, Nakahara T.
Eur J Pharmacol. 2024 May 5;970:176510.
doi: 10.1016/j.ejphar.2024.176510. 

 3)
The Role of microRNAs Related to Apoptosis for N-Methyl-d-Aspartic Acid-Induced Neuronal Cell Death in the Murine Retina.
Sone K, Mori A, Sakamoto K, Nakahara T.
Int J Mol Sci. 2024 Jan 16;25(2):1106. doi: 10.3390/ijms25021106.

 2)
The Anti-Diabetic Drug Metformin Suppresses Pathological Retinal Angiogenesis via Blocking the mTORC1 Signaling Pathway in Mice (Metformin Suppresses Pathological Angiogenesis).
Yagasaki R, Morita A, Mori A, Sakamoto K, Nakahara T.
Curr Eye Res. 2024 May;49(5):505-512.
doi: 10.1080/02713683.2024.2302865.

 1)
Role of mammalian target of rapamycin in the formation and progression of retinopathy of prematurity-like vascular abnormalities in neonatal rats.
Nakano A, Morita A, Arima S, Nagamitsu T, Nakahara T.
Microvasc Res. 2024 Mar;152:104626.
doi: 10.1016/j.mvr.2023.104626.

2023 年

2)
Resveratrol dilates arterioles and protects against N-methyl-d-aspartic acid-induced excitotoxicity in the rat retina.
Mori A, Ezawa Y, Asano D, Kanamori T, Morita A, Kashihara T, Sakamoto K, Nakahara T.
Neurosci Lett. 2023 Jan 10;793:136999.
doi: 10.1016/j.neulet.2022.136999.

1)
The process of methylglyoxal-induced retinal capillary endothelial cell degeneration in rats.
Kamiya E, Morita A, Mori A, Sakamoto K, Nakahara T.
Microvasc Res. 2023 Mar;146:104455.
doi: 10.1016/j.mvr.2022.104455. 

2022 年

4)
Tumor necrosis factor-α and matrix metalloproteinase-9 cooperatively exacerbate neurovascular degeneration in the neonatal rat retina.
Asano D, Kojima M, Morita A, Nakahara T.
Cell Tissue Res. 2022 Nov;390(2):173-187.
doi: 10.1007/s00441-022-03670-5. 

3)
Pharmacological inhibition of Na+/K+-ATPase induces neurovascular degeneration and glial cell alteration in the rat retina.
Nagaoka K, Kurauchi Y, Asano D, Morita A, Sakamoto K, Nakahara T.
Exp Eye Res. 2022 Jul;220:109107.
doi: 10.1016/j.exer.2022.109107. 

 2)
N-Methyl-D-Aspartic Acid Receptor-Mediated Vasodilation Is Attenuated in the Retinas of Diabetic Rats.
Mori A, Yano E, Nishikiori M, Fujino S, Nakahara T.
Curr Eye Res. 2022 Aug;47(8):1193-1199.
doi: 10.1080/02713683.2022.2072896. 

 1)
LPA2 promotes neuronal differentiation and neurite formation in neocortical development.
Uenaka M, Uyeda A, Nakahara T, Muramatsu R.
Biochem Biophys Res Commun. 2022 Apr 2;598:89-94.
doi: 10.1016/j.bbrc.2022.01.109.