Laboratory of Molecular Pharmacology

Laboratory of Molecular Pharmacology

Japanese

Research Achievements

Nakano A, Kawada T, Morita A, Nakahara T.

Repeated treatment with VEGF receptor inhibitors induces phenotypic changes in endothelial cells and pericytes in the rat retina.
Microvasc Res. 2024 Oct 23:104756. 

doi: 10.1016/j.mvr.2024.104756.

Kashihara T, Morita Y, Hatta M, Inoue S, Suzuki Y, Morita A, Nakahara T.

YAP activation in Müller cells protects against NMDA-induced retinal ganglion cell injury by regulating Bcl-xL expression. 
Front Pharmacol. 2024 Aug 6;15:1446521

doi: 10.3389/fphar.2024.1446521.

Nakamura R, Iwai T, Takanezawa Y, Shirahata T, Konishi N, Ohshiro Y, Uraguchi S, Tanabe M, Kobayashi Y, Sakamoto K, Nakahara T, Yamamoto M, Kiyono M.

Oleanolic acid-3-glucoside, a synthetic oleanane-type saponin, ameliorates methylmercury-induced dysfunction of synaptic transmission in mice.
Toxicology. 2024 Aug;506:153867. 

doi: 10.1016/j.tox.2024.153867.

Tomita M, Matsumoto T, Morita A, Itokawa T, Nakahara T, Hori Y.

Optic Nerve Blood Flow in Neonatal Rats with Retinopathy of Prematurity-Like Abnormal Vascular Growth Induced by Vascular Endothelial Growth Factor Receptor Inhibitors
Toho Journal of Medicine. 2024.03;10(1):18-27.

Yamagishi H, Kirai N, Morita A, Kashihara T, Nakahara T.

Role of monocarboxylate transporters in AMPK-mediated protection against excitotoxic injury in the rat retina.
Eur J Pharmacol. 2024 May 5;970:176510.

doi: 10.1016/j.ejphar.2024.176510.

Sone K, Mori A, Sakamoto K, Nakahara T.

The Role of microRNAs Related to Apoptosis for N-Methyl-d-Aspartic Acid-Induced Neuronal Cell Death in the Murine Retina.
Int J Mol Sci. 2024 Jan 16;25(2):1106.

doi: 10.3390/ijms25021106.

Yagasaki R, Morita A, Mori A, Sakamoto K, Nakahara T.

The Anti-Diabetic Drug Metformin Suppresses Pathological Retinal Angiogenesis via Blocking the mTORC1 Signaling Pathway in Mice (Metformin Suppresses Pathological Angiogenesis). 
Curr Eye Res. 2024 May;49(5):505-512

doi: 10.1080/02713683.2024.2302865.

Nakano A, Morita A, Arima S, Nagamitsu T, Nakahara T.

Role of mammalian target of rapamycin in the formation and progression of retinopathy of prematurity-like vascular abnormalities in neonatal rats.
Microvasc Res. 2024 Mar;152:104626. 

doi: 10.1016/j.mvr.2023.104626.

Kamiya E, Morita A, Mori A, Sakamoto K, Nakahara T.

The process of methylglyoxal-induced retinal capillary endothelial cell degeneration in rats.
Microvasc Res. 2023 Mar;146:104455.

doi: 10.1016/j.mvr.2022.104455.

Mori A, Ezawa Y, Asano D, Kanamori T, Morita A, Kashihara T, Sakamoto K, Nakahara T.

Resveratrol dilates arterioles and protects against N-methyl-d-aspartic acid-induced excitotoxicity in the rat retina.
Neurosci Lett. 2023 Jan 10;793:136999.

doi: 10.1016/j.neulet.2022.136999.