分子薬理学教室
分子薬理学教室
English
薬の効き方を知る薬理学の視点から生命のメカニズムを探り、創薬へ応用する
薬の作用を知る薬理学は、生命現象から創薬まで幅広く関わる興味深い分野です。その中でも私たちは網膜の血管に注目して、血管が形成されて維持されるメカニズムを研究しています。網膜血管の異常は、網膜症や緑内障など失明リスクの高い疾患と深く関わっています。新たに分かった血管維持のメカニズムから、網膜の血管が障害されて失明する事態を回避できる、新薬が開発できるかもしれません。
業績
Kashihara T, Morita Y, Hatta M, Inoue S, Suzuki Y, Morita A, Nakahara T.
YAP activation in Müller cells protects against NMDA-induced retinal ganglion cell injury by regulating Bcl-xL expression.
Front Pharmacol. 2024 Aug 6;15:1446521
Nakamura R, Iwai T, Takanezawa Y, Shirahata T, Konishi N, Ohshiro Y, Uraguchi S, Tanabe M, Kobayashi Y, Sakamoto K, Nakahara T, Yamamoto M, Kiyono M.
Oleanolic acid-3-glucoside, a synthetic oleanane-type saponin, ameliorates methylmercury-induced dysfunction of synaptic transmission in mice. Toxicology. 2024 Aug;506:153867.
doi: 10.1016/j.tox.2024.153867.Tomita M, Matsumoto T, Morita A, Itokawa T, Nakahara T, Hori Y.
Optic Nerve Blood Flow in Neonatal Rats with Retinopathy of Prematurity-Like Abnormal Vascular Growth Induced by Vascular Endothelial Growth Factor Receptor Inhibitors
Toho Journal of Medicine. 2024.03;10(1):18-27.
Yamagishi H, Kirai N, Morita A, Kashihara T, Nakahara T.
Role of monocarboxylate transporters in AMPK-mediated protection against excitotoxic injury in the rat retina.
Eur J Pharmacol. 2024 May 5;970:176510.
Sone K, Mori A, Sakamoto K, Nakahara T.
The Role of microRNAs Related to Apoptosis for N-Methyl-d-Aspartic Acid-Induced Neuronal Cell Death in the Murine Retina.
Int J Mol Sci. 2024 Jan 16;25(2):1106.
Yagasaki R, Morita A, Mori A, Sakamoto K, Nakahara T.
The Anti-Diabetic Drug Metformin Suppresses Pathological Retinal Angiogenesis via Blocking the mTORC1 Signaling Pathway in Mice (Metformin Suppresses Pathological Angiogenesis).
Curr Eye Res. 2024 May;49(5):505-512
Nakano A, Morita A, Arima S, Nagamitsu T, Nakahara T.
Role of mammalian target of rapamycin in the formation and progression of retinopathy of prematurity-like vascular abnormalities in neonatal rats.
Microvasc Res. 2024 Mar;152:104626.
Kamiya E, Morita A, Mori A, Sakamoto K, Nakahara T.
The process of methylglyoxal-induced retinal capillary endothelial cell degeneration in rats.
Microvasc Res. 2023 Mar;146:104455.
Mori A, Ezawa Y, Asano D, Kanamori T, Morita A, Kashihara T, Sakamoto K, Nakahara T.
Resveratrol dilates arterioles and protects against N-methyl-d-aspartic acid-induced excitotoxicity in the rat retina.
Neurosci Lett. 2023 Jan 10;793:136999.
Asano D, Kojima M, Morita A, Nakahara T.
Tumor necrosis factor-α and matrix metalloproteinase-9 cooperatively exacerbate neurovascular degeneration in the neonatal rat retina.
Cell Tissue Res. 2022 Nov;390(2):173-187.