分子薬理学教室
分子薬理学教室
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薬の効き方を知る薬理学の視点から生命のメカニズムを探り、創薬へ応用する
薬の作用を知る薬理学は、生命現象から創薬まで幅広く関わる興味深い分野です。その中でも私たちは網膜の血管に注目して、血管が形成されて維持されるメカニズムを研究しています。網膜血管の異常は、網膜症や緑内障など失明リスクの高い疾患と深く関わっています。新たに分かった血管維持のメカニズムから、網膜の血管が障害されて失明する事態を回避できる、新薬が開発できるかもしれません。
業績
Nakano A, Kawada T, Morita A, Nakahara T.
Repeated treatment with VEGF receptor inhibitors induces phenotypic changes in endothelial cells and pericytes in the rat retina.
Microvasc Res. 2024 Oct 23:104756.
Kashihara T, Morita Y, Hatta M, Inoue S, Suzuki Y, Morita A, Nakahara T.
YAP activation in Müller cells protects against NMDA-induced retinal ganglion cell injury by regulating Bcl-xL expression.
Front Pharmacol. 2024 Aug 6;15:1446521
Nakamura R, Iwai T, Takanezawa Y, Shirahata T, Konishi N, Ohshiro Y, Uraguchi S, Tanabe M, Kobayashi Y, Sakamoto K, Nakahara T, Yamamoto M, Kiyono M.
Oleanolic acid-3-glucoside, a synthetic oleanane-type saponin, ameliorates methylmercury-induced dysfunction of synaptic transmission in mice.
Toxicology. 2024 Aug;506:153867.
Tomita M, Matsumoto T, Morita A, Itokawa T, Nakahara T, Hori Y.
Optic Nerve Blood Flow in Neonatal Rats with Retinopathy of Prematurity-Like Abnormal Vascular Growth Induced by Vascular Endothelial Growth Factor Receptor Inhibitors
Toho Journal of Medicine. 2024.03;10(1):18-27.
Yamagishi H, Kirai N, Morita A, Kashihara T, Nakahara T.
Role of monocarboxylate transporters in AMPK-mediated protection against excitotoxic injury in the rat retina.
Eur J Pharmacol. 2024 May 5;970:176510.
Sone K, Mori A, Sakamoto K, Nakahara T.
The Role of microRNAs Related to Apoptosis for N-Methyl-d-Aspartic Acid-Induced Neuronal Cell Death in the Murine Retina.
Int J Mol Sci. 2024 Jan 16;25(2):1106.
Yagasaki R, Morita A, Mori A, Sakamoto K, Nakahara T.
The Anti-Diabetic Drug Metformin Suppresses Pathological Retinal Angiogenesis via Blocking the mTORC1 Signaling Pathway in Mice (Metformin Suppresses Pathological Angiogenesis).
Curr Eye Res. 2024 May;49(5):505-512
Nakano A, Morita A, Arima S, Nagamitsu T, Nakahara T.
Role of mammalian target of rapamycin in the formation and progression of retinopathy of prematurity-like vascular abnormalities in neonatal rats.
Microvasc Res. 2024 Mar;152:104626.
Kamiya E, Morita A, Mori A, Sakamoto K, Nakahara T.
The process of methylglyoxal-induced retinal capillary endothelial cell degeneration in rats.
Microvasc Res. 2023 Mar;146:104455.
Mori A, Ezawa Y, Asano D, Kanamori T, Morita A, Kashihara T, Sakamoto K, Nakahara T.
Resveratrol dilates arterioles and protects against N-methyl-d-aspartic acid-induced excitotoxicity in the rat retina.
Neurosci Lett. 2023 Jan 10;793:136999.