Laboratory of Microbiology
Laboratory of Microbiology
Japanese
Research Achievements
2024年
1.Miki T, Uemura T, Kinoshita M, Ami Y, Ito M, Okada N, Furuchi T, Kurihara S, Haneda T, Minamino T, Kim YG. Salmonella Typhimurium exploits host polyamines for assembly of the type 3 secretion machinery. PLoS Biol. 22(8):e3002731(2024). doi: 10.1371/journal.pbio.3002731
2. Sato K, Hara-Chikuma M, Yasui M, Inoue J, Kim YG. Sufficient water intake maintains the gut microbiota and immune homeostasis and promotes pathogen elimination. iScience.27(6):109903 (2024).doi.org/10.1016/j.isci.2024.109903
3. Otsuka K, Isobe J, Asai Y, Nakano T, Hattori K, Ariyoshi T, Yamashita T, Motegi K, Saito A, Kohmoto M, Hosonuma M, Kuramasu A, Baba Y, Murayama M, Narikawa Y, Toyoda H, Funayama E, Tajima K, Shida M, Hirasawa Y, Tsurui T, Ariizumi H, Ishiguro T, Suzuki R, Ohkuma R, Kubota Y, Sambe T, Tsuji M, Wada S, Kiuchi Y, Kobayashi S, Horiike A, Goto S, Murakami M, Kim YG, Tsunoda T, Yoshimura K. Butyricimonas is a key gut microbiome component for predicting postoperative recurrence of esophageal cancer. Cancer Immunol Immunother. 73(2):23 (2024). doi: 10.1007/s00262-023-03608-y.
4. Fujiki Y, Tanaka T, Yakabe K, Seki N, Akiyama M, Uchida K, Kim YG. Hydrogen gas and the gut microbiota are potential biomarkers for the development of experimental colitis in mice. Gut Microbiome.5:e3 (2024). doi: 10.1017/gmb.2023.17.
2. Sato K, Hara-Chikuma M, Yasui M, Inoue J, Kim YG. Sufficient water intake maintains the gut microbiota and immune homeostasis and promotes pathogen elimination. iScience.27(6):109903 (2024).doi.org/10.1016/j.isci.2024.109903
3. Otsuka K, Isobe J, Asai Y, Nakano T, Hattori K, Ariyoshi T, Yamashita T, Motegi K, Saito A, Kohmoto M, Hosonuma M, Kuramasu A, Baba Y, Murayama M, Narikawa Y, Toyoda H, Funayama E, Tajima K, Shida M, Hirasawa Y, Tsurui T, Ariizumi H, Ishiguro T, Suzuki R, Ohkuma R, Kubota Y, Sambe T, Tsuji M, Wada S, Kiuchi Y, Kobayashi S, Horiike A, Goto S, Murakami M, Kim YG, Tsunoda T, Yoshimura K. Butyricimonas is a key gut microbiome component for predicting postoperative recurrence of esophageal cancer. Cancer Immunol Immunother. 73(2):23 (2024). doi: 10.1007/s00262-023-03608-y.
4. Fujiki Y, Tanaka T, Yakabe K, Seki N, Akiyama M, Uchida K, Kim YG. Hydrogen gas and the gut microbiota are potential biomarkers for the development of experimental colitis in mice. Gut Microbiome.5:e3 (2024). doi: 10.1017/gmb.2023.17.
プレスリリースはこちら
【取材１】【取材２】【取材３】【取材４】
【雑誌１】【雑誌２】
【研究記事１】【研究記事２】【研究記事３】【研究記事４】【研究記事５】
【研究記事６】【研究記事７】【研究記事６】【研究記事９】【研究記事10】
主な論文
1. Fujiki Y, Tanaka T, Yakabe K, Seki N, Akiyama M, Uchida K, Kim YG. Hydrogen gas and the gut microbiota are potential biomarkers for the development of experimental colitis in mice. Gut Microbiome.5:e3 (2024). doi: 10.1017/gmb.2023.17.
2. Yakabe K, Higashi S, Akiyama M, Mori H, Murakami T, Toyoda A, Sugiyama Y, Kishino S, Okano K, Hirayama A, Gotoh A, Li S, Mori T, Katayama T, Ogawa J, Fukuda S, Hase K, Kim YG*. Dietary-protein sources modulate host susceptibility to Clostridioides difficile infection through the gut microbiota. Cell Rep. 40(11):111332 (2022). doi: 10.1016/j.celrep.2022.111332.
3. Seki N, Kimizuka T, Gondo M, Yamaguchi G, Sugiura Y, Akiyama M, Yakabe K, Uchiyama J, Higashi S, Haneda T, Suematsu M, Hase K, Kim YG*. D-Tryptophan suppresses enteric pathogen and pathobionts and prevents colitis by modulating microbial tryptophan metabolism.iScience. 25(8): 104838 (2022). doi:10.1016/j.isci.2022.104838.
4. Tomioka S, Seki N, Sugiura Y, Akiyama M, Uchiyama J, Yamaguchi G, Yakabe K, Ejima R, Hattori K, Kimizuka T, Fujimura Y, Sato H, Gondo M, Ozaki S, Honme Y, Suematsu M, Kimura I, Inohara N, Núñez G, Hase K, Kim YG*. Cooperative action of gut microbiota-accessible carbohydrates improves host metabolic function. Cell Rep. 40(3): 111087 (2022). doi: 10.1016/j.celrep.2022.111087.
5. Dsouza M, Menon R, Crossette E, Bhattarai S, Schneider J, Kim YG, Reddy S, Caballero S, Felix C, Cornacchione L, Hendrickson J, Watson A, Minot S, Greenfield N, Schopf L, Szabady R, Patarroyo J, Smith W, Harrison P, Kuijper E, Kelly C, Olle B, Bobilev D, Bucci V, Roberts B, Faith J, Norman J. Colonization of the Live Biotherapeutic Product VE303 in Healthy Volunteers and Associations with the Resident Microbiota and Metabolites. Cell Host Microbe. 30(4):583-598.e8 (2022). doi: 10.1016/j.chom.2022.03.016.
6. Uchiyama J, Akiyama M*, Hase K, Kumagai Y, Kim YG*. Gut Microbiota Reinforces Host Antioxidant Capacity via the Generation of Reactive Sulfur Species. Cell Rep. 38(10):110479 (2022). doi: 10.1016/j.celrep.2022.110479.
7. KimYG†*, Sakamoto K†, Seo SU, Pickard JM, Gillilland MG III, Pudlo NA, Hoostal M, Li X, Wang TD, Feehley T, Stefka AT, Schmidt TM, Martens EC, Fukuda S, Inohara N, Nagler CR, Núñez G*. Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens. Science. 356(6335):315-319 (2017).†Co-first authors, *Co-corresponding authors.doi: 10.1126/science.aag202
8. Kim YG, Udayanga KG, Totsuka N, Weinberg JB, Núñez G, Shibuya A. Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE2. Cell Host Microbe. 15(1):95-102 (2014). doi:10.1016/j.chom.2013.12.010