微生物学教室
微生物学教室
English
腸内細菌の機能を最大限に引き出し、疾患の治療?予防に生かす
我々の腸内には数百種類、100兆個ほどの細菌が棲息しています。腸内細菌は、自身の持つ菌体成分や代謝物を介して、ヒトの多様な生理機能や疾患病態に影響を与えています。
微生物学教室では、腸内細菌叢の持つ特性を明らかにし、それを活用することにより、感染性?炎症性?代謝性疾患の制御を目指しています。
また、病原細菌による感染症発症の分子機構や、女性生殖器常在乳酸桿菌における有用性機能の解明をめざした研究も進めています。
業績
2024年
1.Miki T, Uemura T, Kinoshita M, Ami Y, Ito M, Okada N, Furuchi T, Kurihara S, Haneda T, Minamino T, Kim YG. Salmonella Typhimurium exploits host polyamines for assembly of the type 3 secretion machinery. PLoS Biol. 22(8):e3002731(2024). doi: 10.1371/journal.pbio.3002731
2. Sato K, Hara-Chikuma M, Yasui M, Inoue J, Kim YG. Sufficient water intake maintains the gut microbiota and immune homeostasis and promotes pathogen elimination. iScience.27(6):109903 (2024).doi.org/10.1016/j.isci.2024.109903
3. Otsuka K, Isobe J, Asai Y, Nakano T, Hattori K, Ariyoshi T, Yamashita T, Motegi K, Saito A, Kohmoto M, Hosonuma M, Kuramasu A, Baba Y, Murayama M, Narikawa Y, Toyoda H, Funayama E, Tajima K, Shida M, Hirasawa Y, Tsurui T, Ariizumi H, Ishiguro T, Suzuki R, Ohkuma R, Kubota Y, Sambe T, Tsuji M, Wada S, Kiuchi Y, Kobayashi S, Horiike A, Goto S, Murakami M, Kim YG, Tsunoda T, Yoshimura K. Butyricimonas is a key gut microbiome component for predicting postoperative recurrence of esophageal cancer. Cancer Immunol Immunother. 73(2):23 (2024). doi: 10.1007/s00262-023-03608-y.
4. Fujiki Y, Tanaka T, Yakabe K, Seki N, Akiyama M, Uchida K, Kim YG. Hydrogen gas and the gut microbiota are potential biomarkers for the development of experimental colitis in mice. Gut Microbiome.5:e3 (2024). doi: 10.1017/gmb.2023.17.
2. Sato K, Hara-Chikuma M, Yasui M, Inoue J, Kim YG. Sufficient water intake maintains the gut microbiota and immune homeostasis and promotes pathogen elimination. iScience.27(6):109903 (2024).doi.org/10.1016/j.isci.2024.109903
3. Otsuka K, Isobe J, Asai Y, Nakano T, Hattori K, Ariyoshi T, Yamashita T, Motegi K, Saito A, Kohmoto M, Hosonuma M, Kuramasu A, Baba Y, Murayama M, Narikawa Y, Toyoda H, Funayama E, Tajima K, Shida M, Hirasawa Y, Tsurui T, Ariizumi H, Ishiguro T, Suzuki R, Ohkuma R, Kubota Y, Sambe T, Tsuji M, Wada S, Kiuchi Y, Kobayashi S, Horiike A, Goto S, Murakami M, Kim YG, Tsunoda T, Yoshimura K. Butyricimonas is a key gut microbiome component for predicting postoperative recurrence of esophageal cancer. Cancer Immunol Immunother. 73(2):23 (2024). doi: 10.1007/s00262-023-03608-y.
4. Fujiki Y, Tanaka T, Yakabe K, Seki N, Akiyama M, Uchida K, Kim YG. Hydrogen gas and the gut microbiota are potential biomarkers for the development of experimental colitis in mice. Gut Microbiome.5:e3 (2024). doi: 10.1017/gmb.2023.17.
プレスリリースはこちら
【取材１】【取材２】【取材３】【取材４】
【雑誌１】【雑誌２】
【研究記事１】【研究記事２】【研究記事３】【研究記事４】【研究記事５】
【研究記事６】【研究記事７】【研究記事６】【研究記事９】【研究記事10】
主な論文
1. Fujiki Y, Tanaka T, Yakabe K, Seki N, Akiyama M, Uchida K, Kim YG. Hydrogen gas and the gut microbiota are potential biomarkers for the development of experimental colitis in mice. Gut Microbiome.5:e3 (2024). doi: 10.1017/gmb.2023.17.
2. Yakabe K, Higashi S, Akiyama M, Mori H, Murakami T, Toyoda A, Sugiyama Y, Kishino S, Okano K, Hirayama A, Gotoh A, Li S, Mori T, Katayama T, Ogawa J, Fukuda S, Hase K, Kim YG*. Dietary-protein sources modulate host susceptibility to Clostridioides difficile infection through the gut microbiota. Cell Rep. 40(11):111332 (2022). doi: 10.1016/j.celrep.2022.111332.
3. Seki N, Kimizuka T, Gondo M, Yamaguchi G, Sugiura Y, Akiyama M, Yakabe K, Uchiyama J, Higashi S, Haneda T, Suematsu M, Hase K, Kim YG*. D-Tryptophan suppresses enteric pathogen and pathobionts and prevents colitis by modulating microbial tryptophan metabolism.iScience. 25(8): 104838 (2022). doi:10.1016/j.isci.2022.104838.
4. Tomioka S, Seki N, Sugiura Y, Akiyama M, Uchiyama J, Yamaguchi G, Yakabe K, Ejima R, Hattori K, Kimizuka T, Fujimura Y, Sato H, Gondo M, Ozaki S, Honme Y, Suematsu M, Kimura I, Inohara N, Núñez G, Hase K, Kim YG*. Cooperative action of gut microbiota-accessible carbohydrates improves host metabolic function. Cell Rep. 40(3): 111087 (2022). doi: 10.1016/j.celrep.2022.111087.
5. Dsouza M, Menon R, Crossette E, Bhattarai S, Schneider J, Kim YG, Reddy S, Caballero S, Felix C, Cornacchione L, Hendrickson J, Watson A, Minot S, Greenfield N, Schopf L, Szabady R, Patarroyo J, Smith W, Harrison P, Kuijper E, Kelly C, Olle B, Bobilev D, Bucci V, Roberts B, Faith J, Norman J. Colonization of the Live Biotherapeutic Product VE303 in Healthy Volunteers and Associations with the Resident Microbiota and Metabolites. Cell Host Microbe. 30(4):583-598.e8 (2022). doi: 10.1016/j.chom.2022.03.016.
6. Uchiyama J, Akiyama M*, Hase K, Kumagai Y, Kim YG*. Gut Microbiota Reinforces Host Antioxidant Capacity via the Generation of Reactive Sulfur Species. Cell Rep. 38(10):110479 (2022). doi: 10.1016/j.celrep.2022.110479.
7. KimYG†*, Sakamoto K†, Seo SU, Pickard JM, Gillilland MG III, Pudlo NA, Hoostal M, Li X, Wang TD, Feehley T, Stefka AT, Schmidt TM, Martens EC, Fukuda S, Inohara N, Nagler CR, Núñez G*. Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens. Science. 356(6335):315-319 (2017).†Co-first authors, *Co-corresponding authors.doi: 10.1126/science.aag202
8. Kim YG, Udayanga KG, Totsuka N, Weinberg JB, Núñez G, Shibuya A. Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE2. Cell Host Microbe. 15(1):95-102 (2014). doi:10.1016/j.chom.2013.12.010