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Laboratory of Clinical Pharmacoepidemiology

Laboratory of Clinical Pharmacoepidemiology

Japanese

Creating essential evidence from real-world healthcare data, focusing on the patient’s perspective.


Pharmacoepidemiology has evolved as a "bridging science," integrating clinical pharmacology and therapeutics with epidemiology to address societal needs.
At our laboratory, we leverage real-world data generated from everyday clinical practice to conduct comprehensive analyses of drug therapy, uncovering insights often beyond the reach of conventional clinical trials.
By focusing on evidence creation from the patient’s perspective, we aim to contribute to the development of safer and more effective drug therapies, ultimately enhancing patient outcomes.

Research Achievements

  • Original Articles
  • Lecture/Conference
  • Books/Publications

    • Research on Information Used in the Development of Pediatric Drugs in Japan: Utilization of Pharmacokinetic Information

    Michiru Ochiai, Mika Maeda,Wakana Kuwano, Mami Suzuki, Masako Aso, Masahiro Kobayashi, Katsuya Otori, Tomoko Hasunuma, Yuji Kumagai.
    Rinsho Yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 55 (1) :3-10 (2024)


    Pharmacokinetics of Low Doses of Colchicine in the Leukocytes of Japanese Healthy Individuals

    Akiko Mutoh, Hitoshi Uehara, Asano Maeda, Akihiro Tokushige, Yasushi Higashiuesato, Mika Maeda, Yuji Kumagai, Shinichiro Ueda.
    Translational and Clinical Pharmacology, 31 (4) :217-225 (2023)


    Efficacy and Safety of Single-dose Ivermectin in Mild-to-moderate COVID-19: the Double-blind, Randomized, Placebo-controlled CORVETTE-01 Trial

    Tatsuhiko Wada, Makoto Hibino, Hiromi Aono, Shunsuke Kyoda, Yosuke Iwadate, Eri Shishido, Keisuke Ikeda, Nana Kinoshita, Yasuki Matsuda, Sakiko Otani, Ryo Kameda, Kenta Matoba, Miwa Nonaka, Mika Maeda, Yuji Kumagai, Junya Ako, Masayoshi Shichiri, Katsuhiko Naoki, Masato Katagiri, Masashi Takaso, Masatsugu Iwamura, Kazuhiko Katayama, Takeshi Miyatsuka, Yasushi Orihashi, Kunihiro Yamaoka.
    Frontiers in Medicine, 10 :1139046 (2023)


    Hepatic Adaptation to Therapeutic Doses of Acetaminophen: An Exploratory Study in Healthy Individuals.

    Mika Maeda;Rieko Tanaka;Masako Aso;Yasutoshi Sakamoto;Ildae Song;Michiru Ochiai;Yoshiro Saito;Keiko Maekawa;Noriaki Arakawa;Yasuo Ohno;Yuji Kumagai.
    Clinical therapeutics, 42 (7) :1276-1291 (2020)


    A Drug-Drug Interaction Study to Evaluate the Effect of TAS-303 on CYP3A Activity in the Small Intestine and Liver.

    Yuji Kumagai;Tomoe Fujita;Mika Maeda;Yoshinobu Sasaki;Makoto Nagaoka;Jinhong Huang;Toru Takenaka;Masaki Kawai.
    Journal of clinical pharmacology, 60 (6) :702-710 (2020)


    A 3-Part Phase 1 Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DSP-6952 in Healthy Japanese Subjects and Those With ≤3 Spontaneous Bowel Movements per Week.

    Takuya Yumizaki;Mika Maeda;Tomoe Fujita;Hiroyoshi Kakuyama;Yuji Kumagai.
    Clinical pharmacology in drug development, 9 (3) :353-365 (2020)


    Effect of single and multiple doses of elobixibat, an ileal bile acid transporter inhibitor, on chronic constipation: A randomized controlled trial.

    Yuji Kumagai; Hideki Amano; Yoshinobu Sasaki; Chie Nakagawa; Mika Maeda; Ichiro Oikawa; Hidetoshi Furuie.
    British journal of clinical pharmacology, 84 (10) :2393-2404 (2018)


    Pharmacokinetics and Pharmacodynamics of a Single Dose of Scopolamine Ointment Applied to the Postauricular Area in Healthy Subjects

    Maeda Mika; Fujita Tomoe; Amano Hideki; Kohara Harue; Yamazaki Akira; Hirayama Takeshi; Kuroyama Masakazu; Ogino Mieko; Nagashima Kazuaki; Akutsu Tsugio; Nishiyama Kazutoshi; Kumagai Yuji.
    Japanese Journal of Clinical Pharmacology and Therapeutics, 49 (2) :53-58 (2018)


    Influences of Long-Term, High-Dose Acetaminophen Administration on Liver Function Markers in Healthy Japanese Adults

    Song Ildae; Tanaka Rieko; Aso Masako; Sakamoto Yasutoshi; Maeda Mika; Ochiai Michiru; Saito Yoshiro; Maekawa Keiko; Kumagai Yuji.
    Japanese Journal of Clinical Pharmacology and Therapeutics, 48 (5) :153-159 (2017)


    Population Pharmacokinetic-Pharmacodynamic Analysis to Compare the Effect of Moxifloxacin on QT Interval Prolongation Between Healthy Korean and Japanese Subjects.

    Population Pharmacokinetic-Pharmacodynamic Analysis to Compare the Effect of Moxifloxacin on QT Interval Prolongation Between Healthy Korean and Japanese Subjects..
    Clinical therapeutics, 38 (12) :2610-2621 (2016)