臨床薬剤疫学
臨床薬剤疫学
English
薬物療法の実態を多角的に分析し、より安全で効果的な薬物療法の実現に貢献する。
薬剤疫学（pharmacoepidemiology）は、臨床薬理学（clinical pharmacology and therapeutics）と疫学（epidemiology）を融合した「橋渡しのサイエンス」として、社会的な要請に応えながら発展してきた分野です。当研究室では、実臨床における薬物療法の課題や疑問に向き合い、日々の診療で蓄積される医療情報（リアルワールドデータ）を活用して、薬物療法の実態を多角的に分析しています。患者視点を重視したエビデンスの創出を通じて、より安全で効果的な薬物療法の実現に向けて貢献することを目指しています。
業績
Research on Information Used in the Development of Pediatric Drugs in Japan: Utilization of Pharmacokinetic Information
Michiru Ochiai, Mika Maeda,Wakana Kuwano, Mami Suzuki, Masako Aso, Masahiro Kobayashi, Katsuya Otori, Tomoko Hasunuma, Yuji Kumagai.
Rinsho Yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 55 (1) :3-10 (2024)
Pharmacokinetics of Low Doses of Colchicine in the Leukocytes of Japanese Healthy Individuals
Akiko Mutoh, Hitoshi Uehara, Asano Maeda, Akihiro Tokushige, Yasushi Higashiuesato, Mika Maeda, Yuji Kumagai, Shinichiro Ueda.
Translational and Clinical Pharmacology, 31 (4) :217-225 (2023)
Efficacy and Safety of Single-dose Ivermectin in Mild-to-moderate COVID-19: the Double-blind, Randomized, Placebo-controlled CORVETTE-01 Trial
Tatsuhiko Wada, Makoto Hibino, Hiromi Aono, Shunsuke Kyoda, Yosuke Iwadate, Eri Shishido, Keisuke Ikeda, Nana Kinoshita, Yasuki Matsuda, Sakiko Otani, Ryo Kameda, Kenta Matoba, Miwa Nonaka, Mika Maeda, Yuji Kumagai, Junya Ako, Masayoshi Shichiri, Katsuhiko Naoki, Masato Katagiri, Masashi Takaso, Masatsugu Iwamura, Kazuhiko Katayama, Takeshi Miyatsuka, Yasushi Orihashi, Kunihiro Yamaoka.
Frontiers in Medicine, 10 :1139046 (2023)
Hepatic Adaptation to Therapeutic Doses of Acetaminophen: An Exploratory Study in Healthy Individuals.
Mika Maeda;Rieko Tanaka;Masako Aso;Yasutoshi Sakamoto;Ildae Song;Michiru Ochiai;Yoshiro Saito;Keiko Maekawa;Noriaki Arakawa;Yasuo Ohno;Yuji Kumagai.
Clinical therapeutics, 42 (7) :1276-1291 (2020)
A Drug-Drug Interaction Study to Evaluate the Effect of TAS-303 on CYP3A Activity in the Small Intestine and Liver.
Yuji Kumagai;Tomoe Fujita;Mika Maeda;Yoshinobu Sasaki;Makoto Nagaoka;Jinhong Huang;Toru Takenaka;Masaki Kawai.
Journal of clinical pharmacology, 60 (6) :702-710 (2020)
A 3-Part Phase 1 Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DSP-6952 in Healthy Japanese Subjects and Those With ≤3 Spontaneous Bowel Movements per Week.
Takuya Yumizaki;Mika Maeda;Tomoe Fujita;Hiroyoshi Kakuyama;Yuji Kumagai.
Clinical pharmacology in drug development, 9 (3) :353-365 (2020)
Effect of single and multiple doses of elobixibat, an ileal bile acid transporter inhibitor, on chronic constipation: A randomized controlled trial.
Yuji Kumagai; Hideki Amano; Yoshinobu Sasaki; Chie Nakagawa; Mika Maeda; Ichiro Oikawa; Hidetoshi Furuie.
British journal of clinical pharmacology, 84 (10) :2393-2404 (2018)
Pharmacokinetics and Pharmacodynamics of a Single Dose of Scopolamine Ointment Applied to the Postauricular Area in Healthy Subjects
Maeda Mika; Fujita Tomoe; Amano Hideki; Kohara Harue; Yamazaki Akira; Hirayama Takeshi; Kuroyama Masakazu; Ogino Mieko; Nagashima Kazuaki; Akutsu Tsugio; Nishiyama Kazutoshi; Kumagai Yuji.
Japanese Journal of Clinical Pharmacology and Therapeutics, 49 (2) :53-58 (2018)
Influences of Long-Term, High-Dose Acetaminophen Administration on Liver Function Markers in Healthy Japanese Adults
Song Ildae; Tanaka Rieko; Aso Masako; Sakamoto Yasutoshi; Maeda Mika; Ochiai Michiru; Saito Yoshiro; Maekawa Keiko; Kumagai Yuji.
Japanese Journal of Clinical Pharmacology and Therapeutics, 48 (5) :153-159 (2017)
Population Pharmacokinetic-Pharmacodynamic Analysis to Compare the Effect of Moxifloxacin on QT Interval Prolongation Between Healthy Korean and Japanese Subjects.
Population Pharmacokinetic-Pharmacodynamic Analysis to Compare the Effect of Moxifloxacin on QT Interval Prolongation Between Healthy Korean and Japanese Subjects..
Clinical therapeutics, 38 (12) :2610-2621 (2016)