臨床薬剤疫学
臨床薬剤疫学
English
医療現場で積み上げられた医療情報を源泉に、患者の視点から必要となる薬物療法の有用性、安全性、経済性に関するエビデンスを届ける。
薬剤疫学（pharmacoepidemiology）は、社会の要望に応えながら発展を続けてきた学問?研究領域で、臨床薬理学（clinical pharmacology)と疫学（epidemiology）を繋ぐ「橋渡しのサイエンス」とも呼ばれています。この研究室では、医療現場における薬物療法の課題や疑問に向き合い、医療情報を利活用した薬剤疫学研究を中心に、より良い薬物療法のあり方を研究します。
業績
Hepatic Adaptation to Therapeutic Doses of Acetaminophen: An Exploratory Study in Healthy Individuals.
Mika Maeda;Rieko Tanaka;Masako Aso;Yasutoshi Sakamoto;Ildae Song;Michiru Ochiai;Yoshiro Saito;Keiko Maekawa;Noriaki Arakawa;Yasuo Ohno;Yuji Kumagai.
Clinical therapeutics, 42 (7) :1276-1291 (2020)
A Drug-Drug Interaction Study to Evaluate the Effect of TAS-303 on CYP3A Activity in the Small Intestine and Liver.
Yuji Kumagai;Tomoe Fujita;Mika Maeda;Yoshinobu Sasaki;Makoto Nagaoka;Jinhong Huang;Toru Takenaka;Masaki Kawai.
Journal of clinical pharmacology, 60 (6) :702-710 (2020)
A 3-Part Phase 1 Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DSP-6952 in Healthy Japanese Subjects and Those With ≤3 Spontaneous Bowel Movements per Week.
Takuya Yumizaki;Mika Maeda;Tomoe Fujita;Hiroyoshi Kakuyama;Yuji Kumagai.
Clinical pharmacology in drug development, 9 (3) :353-365 (2020)
Effect of single and multiple doses of elobixibat, an ileal bile acid transporter inhibitor, on chronic constipation: A randomized controlled trial.
Yuji Kumagai; Hideki Amano; Yoshinobu Sasaki; Chie Nakagawa; Mika Maeda; Ichiro Oikawa; Hidetoshi Furuie.
British journal of clinical pharmacology, 84 (10) :2393-2404 (2018)
Pharmacokinetics and Pharmacodynamics of a Single Dose of Scopolamine Ointment Applied to the Postauricular Area in Healthy Subjects
Maeda Mika; Fujita Tomoe; Amano Hideki; Kohara Harue; Yamazaki Akira; Hirayama Takeshi; Kuroyama Masakazu; Ogino Mieko; Nagashima Kazuaki; Akutsu Tsugio; Nishiyama Kazutoshi; Kumagai Yuji.
Japanese Journal of Clinical Pharmacology and Therapeutics, 49 (2) :53-58 (2018)
Influences of Long-Term, High-Dose Acetaminophen Administration on Liver Function Markers in Healthy Japanese Adults
Song Ildae; Tanaka Rieko; Aso Masako; Sakamoto Yasutoshi; Maeda Mika; Ochiai Michiru; Saito Yoshiro; Maekawa Keiko; Kumagai Yuji.
Japanese Journal of Clinical Pharmacology and Therapeutics, 48 (5) :153-159 (2017)
Population Pharmacokinetic-Pharmacodynamic Analysis to Compare the Effect of Moxifloxacin on QT Interval Prolongation Between Healthy Korean and Japanese Subjects.
Population Pharmacokinetic-Pharmacodynamic Analysis to Compare the Effect of Moxifloxacin on QT Interval Prolongation Between Healthy Korean and Japanese Subjects..
Clinical therapeutics, 38 (12) :2610-2621 (2016)
Comparative Pharmacokinetic Study of Acetaminophen in Japanese and Han Chinese Individuals
Hyang-Ki Choi; Jin Ah Jung; Tomoe Fujita; Hideki Amano; Jong-Lyul Ghim; Dong-Hwan Lee; Kenichi Tabata; Il-Dae Song; Mika Maeda; Yuji Kumagai; Boaz Mendzelevski; Jae-Gook Shin.
Japanese Journal of Clinical Pharmacology and Therapeutics, 47 (1) :11-16 (2016)