生薬学教室
生薬学教室
English
薬用植物の品質や薬効を科学的に解明して、漢方や予防医学に役立てる。
東洋の漢方薬や中医薬、西洋の植物療法、アロマセラピーなどで利用される薬用植物を対象に、東洋医学総合研究所と協力して、化学成分の網羅的解析や薬効評価研究を行います。数千年前から植物を健康維持に使ってきた人類の知恵を、医薬品や機能性食品に上手に活用したいですね。
業績
Overlooked switch from transient sedation to sustained excitement in the Biphasic effects of Ephedra Herb extract administered orally to mice
Huang X, Hyuga S, Amakura Y, Hyuga M, Uchiyama N, Hakamatsuka T, Goda Y, Odaguchi D, Hanawa T, Kobayashi Y.
Journal of Ethnopharmacology, 301 :115827-115827 (2023)
Near-Infrared Metabolic Profiling for Discrimination of Apricot and Peach Kernels
Shirahata T, Kanazawa A, Uematsu M, Fuchino H, Kawano N, Kawahara N, Yoshimatsu Y, Hanawa T, Odaguchi H, Kobayashi Y.
Chemical and Pharmaceutical Bulletin, 70 (12) :863-867 (2022)
https://doi.org/10.1248/cpb.c21-01102
Kampo formulas alleviate aging-related emotional disturbances and neuroinflammation in male senescence-accelerated mouse prone 8 mice
Ito N, Maruko A, Oshima K, Yoshida M, Honma K, Sugiyama C, Nagai T, Kobayashi Y, Odaguchi H, Okada N.
Aging, 14 (1) :109-142 (2022)
Preparation of tenuifolin from Polygala senega L. root using a hydrolytic continuous flow system under high-temperature,high-pressure conditions
Shirahata T, Miyaishi R, Kitazoe K, Saito M, Taneoka M, Hidaka S, Yokoyama M, Tojima T, Katsumi T, Hirata N, Nishino T, Kaji E, Yamada H, Nagai N, Kiyohara H, Nakamori S, Konishi N, Kobayashi Y.
The Journal of Organic Chemistry, 86 (23) :16268-16277 (2021)
Efficient synthesis of diverse C-3 monodesmosidic saponins by a continuous microfluidic glycosylation/batch deprotection method
Konishi N, Shirahata T, Yoshida Y, Sato N, Kaji E, Kobayashi Y.
Carbohydrate Research, 510 :108437 (2021)
Metabolic fingerprinting for discrimination of DNA-authenticated Atractylodes plants using 1H NMR spectroscopy
Shirahata T, Ishikawa H, Kudo T, Takada Y, Hoshino A, Taga Y, Minakuchi Y, Hasegawa T, Horiguchi R, Hirayama T, Konishi T, Takemoto H, Sato N, Aragane M, Oikawa T, Odaguchi H, Hanawa T, Kodaira E, Fukuda T, Kobayashi Y.
Journal of Natural Medicines, 75 (3) :475-488 (2021)
Unified enantioselective total synthesis of 3,6-dioxygenated diketopiperazine natural products,diatretol and lepistamides A,B and C
Takahashi S, Kimishima A, Hirose T, Yamada T, Sugawara A, Shirahata T, Yoshihiko N, Iwatsuki M, Hokari R, Ishiyama A, Kobayashi Y, Sunazuka T..
Tetrahedron Letters, 67 :152895 (2021)