生薬学教室
生薬学教室
English
薬用植物の品質や薬効を科学的に解明して、漢方や予防医学に役立てる。
東洋の漢方薬や中医薬、西洋の植物療法、アロマセラピーなどで利用される薬用植物を対象に、東洋医学総合研究所と協力して、化学成分の網羅的解析や薬効評価研究を行います。数千年前から植物を健康維持に使ってきた人類の知恵を、医薬品や機能性食品に上手に活用したいですね。
業績
Celludinone C, a new dihydroisobenzofuran isolated from Talaromyces cellulolyticus BF-0307.
Reiko Seki, Keisuke Kobayashi, Satoru Shigeno, Tatsuya Shirahata, Yoshinori Kobayashi, Taichi Ohshiro, Hiroshi Tomoda, Kenichiro Nagai
The Journal of Antibiotics 78(1) 26-34 (2025)
https://doi.org/10.1038/s41429-024-00785-5
1H-NMR-Based Biochemometric Strategy to Identify Transient Receptor Potential Vanilloid 1-Stimulating Compounds from Alpinia officinarum Rhizome
Tomohisa Kanaia, Tatsuya Shirahataa*, Shunsuke Nakamori, Rin Sato, Akito Hayashi, Yota Koizumi, Kenichiro Nagai, Susumu Ohkawara, Takayuki Hoshino, Toshiko Tanaka-Kagawa, Hideto Jinno, Yoshinori Kobayashi
Chemical and Pharmaceutical Bulletin 73(3) 195-204 (2025)
https://doi.org/10.1248/cpb.c24-00707
Preventive and therapeutic effects of ephedrine alkaloids-free Ephedra Herb extract on paclitaxel-induced neuropathic pain
Xuedan Huang, Sumiko Hyuga, Michiho Ito, Yukihiro Goda, Yoshinori Kobayashi
J Nat Med. (2024)
Intron retention as an excellent marker for diagnosing depression and for discovering new potential pathways for drug intervention
Norihiro Okada, Kenshiro Oshima, Akiko Maruko, Mariko Sekine, Naoki Ito, Akino Wakasugi, Eiko Mori, Hiroshi Odaguchi, Yoshinori Kobayashi
Front. Psychiatry 15:1450708 (2024).
Development of a determination method for quality control markers utilizing metabolic profiling and its application on processed Zingiber officinale Roscoe rhizome
Tomohisa Kanai, Tatsuya Shirahata, Shunsuke Nakamori, Yota Koizumi, Eiichi Kodaira, Noriko Sato, Hiroyuki Fuchino, Noriaki Kawano, Nobuo Kawahara, Takayuki Hoshino, Kayo Yoshimatsu, Yoshinori Kobayashi
J Nat Med 78, 952-969 (2024)
Oleanolic acid-3-glucoside, a synthetic oleanane-type saponin, ameliorates methylmercury-induced dysfunction of synaptic transmission in mice.
Ryosuke Nakamura, Takashi Iwai, Yasukazu Takanezawa, Tatsuya Shirahata, Naruki Konishi, Yuka Ohshiro, Shimpei Uraguchi, Mitsuo Tanabe, Yoshinori Kobayashi, Kenji Sakamoto, Tsutomu Nakahara, Megumi Yamamoto, Masako Kiyono.
Toxicology 506 153867-153867 (2024)
Intron retention can be an excellent marker for evaluating the depressed state and useful for discovering new pathways in the recovery of depression by a drug
Norihiro Okada, Kenshiro Oshima, Akiko Maruko, Mariko Sekine, Naoki Ito, Akino Wakasugi, Eiko Mori, Hiroshi Odaguchi, Yoshinori Kobayashi
Front Psychiatry. 15:1450708(2024).
Improved quantitative analysis of tenuifolin using hydrolytic continuous-flow system to build prediction models for its content based on near-infrared spectroscopy
Tatsuki Kitazoe, Chisato Usui, Eiichi Kodaira, Takuro Maruyama, Noriaki Kawano, Hiroyuki Fuchino, Kazuhiko Yamamoto, Yasushi Kitano, Nobuo Kawahara, Kayo Yoshimatsu, Tatsuya Shirahata, Yoshinori Kobayashi
J Nat Med. 78(2):296-311(2024)
The suppression of the differentiation of adipocytes with Mallotus furetianus is regulated through the posttranslational modifications of C/EBPβ
Touko Nakano, Yutaro Sasaki, Toshio Norikura, Yusuke Hosokawa, Mayu Kasano, Isao Matsui-Yuasa, Xuedan Huang, Yoshinori Kobayashi, Akiko Kojima-Yuasa
Food Sci Nutr. 11(10):6151-6163 (2023)