臨床薬学研究部門
臨床薬学研究部門
English
基礎研究の成果を臨床薬学に活かす。
トランスレーショナルリサーチの実践を目指す。
活性酸素は、糖尿病をはじめとした生活習慣病の発症や悪化、あるいは有毒物質の毒性発現の要因となることが知られています。この部門では、様々な病気の発症機構や有毒物質の毒性発現における活性酸素の役割を解明し、基礎研究での成果を新たな薬物治療法の開発などへ発展させる研究を目指しています。
業績
業績
2024年
Tsuruta K, Matsuoka M, Harada S, Enomoto A, Kumagai T, Yasuda S, Koumura T, Yamada KI, Imai H.: Slowly progressive cell death induced by GPx4-deficiency occurs via MEK1/ERK2 activation as a downstream signal after iron-independent lipid peroxidation. J.Clin.Biochem. Nutr. 74 : 97-107, 2024.
2017年
Imai H., Matsuoka M., Kumagai T., Sakamoto T., and Koumura T.: Lipid peroxidation-dependent cell death regulation by GPx4 and ferroptosis. Curr. Top. Microbiol. Immunol. 403 : 143-170, 2017.
2015年
Kumagai T., Kozakai.Y., Ishino T., Yajima Y., Nakagawa Y. and Imai H.: Nrf2 up-regulates the induction of acidic sphingomyelinase by electrophiles. J. Biochem. 158 : 127-137, 2015
Kumagai T., Usami H., Matsukawa N., Nakashima F., Chikazawa M., Shibata T., Noguchi N., and Uchida K.: Functional interaction between cyclooxygenase and p53 in response to an endogenous electrophile. Redox Biol. 4 : 74-86, 2015.
2012年
Kumagai T., Ishino T., and Nakagawa Y.: Acidic sphingomyelinase induced by electrophiles promotes proinflammatory cytokine production in human bladder carcinoma ECV-304 cells. Arch. Biochem. Biophys. 519 : 8-16, 2012.
?2010年
Sakaue M., Mori N., Okazaki M., Ishii M., Inagaki Y., Iino Y., Miyahara K., Yamamoto M.,Kumagai T., Hara S., and Yamamoto M.,: Involvement of independent mechanism upon poly(ADP-ribose) polymerase (PARP) activation in methylmercury cytotoxicity in rat cerebellar granule cell culture. J.Neurosci. Res. 86 : 3427-3434, 2008.
Miyoshi N, Naniwa K, Kumagai T., Uchida K, Osawa T, and Nakamura Y. : Alpha-tocopherol-mediated caspase-3 up-regulation enhances susceptibility to apoptotic stimuli. Biochem Biophys Res Commun. 334 : 466-73, 2005.
Usami H, Kusano Y, Kumagai T., Osada S, Itoh K, Kobayashi A, Yamamoto M, and Uchida K. : Selective induction of the tumor marker glutathione S-transferase P1 by proteasome inhibitors. J Biol Chem. 280 :25267-76, 2005.
Kumagai T., Matsukawa N., Kaneko Y., Kusumi Y., Mitsumata M., and Uchida K.: A lipid peroxidation-derived inflammatory mediator: identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macropharges. J. Biol. Chem. 279 : 48389-48396, 2004.
Feng Q.,Kumagai T., Nakamura Y., Uchida K. and Osawa T.:Correlation of antimutagenic activity and suppression of CYP1A with the lipophilicity of alkyl gallates and other phenolic compounds. Mutant. Res. 537 : 101-108, 2003.
Nakamura Y.,Kumagai T., Yoshida C., Naito Y., Miyamoto M., Ohigashi H., Osawa T. and Uchida, K.: Pivotal role of electrophilicity in glutathione-S-transferase induction by tert-butylhydroquinone. Biochemistry 42 : 4300-4309, 2003.
Uchida K. and Kumagai T.: 4-hydroxy-2-nonenal as a COX-2 inducer. Mol.Aspects Med. 24 : 213-218, 2003.
Feng Q., Kumagai T., Nakamura Y., Uchida K. and Osawa T.: Induction of cytochrome P4501A1 by autoclavable culture medium change in HepG2 cells. Xenobiotica. 32 : 1033-1043, 2002.
Kondo M., Shibata T., Kumagai T., Osawa T., Shibata N., Kobayashi M., Sasaki S., Iwata M., Noguchi N. and Uchida K.: 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis. Proc. Natl. Acad. Sci. U S A. 99 : 7367-7372, 2002.
Kumagai T., Nakamura Y., Osawa T. and Uchida K.: Role of p38 mitogen-activated protein kinase in the 4-hydroxy-2-nonenal-induced cyclooxygenase-2 expression. Arch. Biochem. Biophys. 397 : 240-245, 2002.
Nakamura Y., Feng Q., Kumagai T., Torikai K., Ohigashi H., Osawa T., Noguchi N., Niki E. and Uchida K.: Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis. J. Biol. Chem. 277 : 2687-2694, 2002.
Morimitsu Y., Nakagawa Y., Hayashi K., Fujii H., Kumagai T., Nakamura Y., Osawa T., Horio F., Itoh K., Iida K., Yamamoto M. and Uchida K.: A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway. J. Biol. Chem. 277 : 3456-3463, 2002.
Feng Q.,Kumagai T., Torii Y., Nakamura Y., Osawa T. and Uchida K.: Anticarcinogenic antioxidants as inhibitors against intracellular oxidative stress. Free Radic. Res. 35 : 779-788, 2001.
Minekura H., Kumagai T.., Kawamoto Y., Nara F. and Uchida K.: 4-Hydroxy-2-nonenal is a powerful endogenous inhibitor of endothelial response. Biochem. Biophys. Res. Commun. 282 : 557-561, 2001.
Kondo M., Oya-Ito T., Kumagai T., Osawa T. and Uchida K.: Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress. J. Biol. Chem. 276 : 12076-12083, 2001.
Kumagai T., Kawamoto Y., Nakamura Y., Hatayama I., Satoh K., Osawa T. and Uchida K.: 4-Hydroxy-2-nonenal, the End Product of Lipid Peroxidation, Is a Specific Inducer of Cyclooxygenase-2 Gene Expression. Biochem. Biophys. Res. Commun. 273 : 437-441, 2000.
Kawamoto Y., Nakamura Y., Naito Y., Torii Y.,Kumagai T., Osawa T., Ohigashi H., Satoh K., Imagawa M. and Uchida K.: Cyclopentenone prostaglandins as potential inducers of phase II detoxification enzymes 15-deoxy-Delta(12,14)-prostaglandin J2-induced expression of glutathione S-transferases. J. Biol. Chem. 275 : 11291-11299, 2000.
Kumagai T., Yokoyama H., Goto A., Hirose J., Kadowaki T., Narita H. and Kitagawa Y.: Screening for Drosophila proteins with distinct expression patterns during development by use of monoclonal antibodies. Biosci. Biotechnol. Biochem. 64 : 24-8, 2000.
Suzuki H., Kumagai T., Sugiura T. and Goto A.: Increase in intracellular hydrogen peroxide and upregulation of a nuclear respiratory gene evoked by impairment of mitochondrial electron transfer in human cells. Biochem. Biophys. Res. Commun. 249 : 542-5, 1998.