1) 各種動物疾患についての病理組織診断学の構築. 家畜（牛, 馬, 豚, 山羊）, 伴侶動物（犬, 猫）, 野生動物（鹿, タヌキ, アナグマ, ノウサギ）, 実験動物（マウス, ラット）の自然発生疾患（腫瘍, 感染症など）に関する診断病理学的研究を遂行しています. 2) 病態モデルミニブタを用いて, 動脈硬化, メタボ, 皮膚炎, ストレスなどの病理発生機序の解明や予防?治療法の開発を研究しています. 特にヒト型動脈硬化モデルマイクロミニピッグを用いて獣医循環器病理学、さらに腫瘍循環器学（Onco-cardiology）に貢献する基礎研究に取り組んでいます. 3) 狂犬病に関する病理学的研究を行っています. 狂犬病による死者は毎年約6万人ですが, 本疾患の発病機序については不明な点が多いです. 現在, 当研究室では諸外国の研究機関と協力しながら, 犬, 猫, 野生動物, 実験動物における ウイルスの侵入と排泄機構, 封入体の形成機序および脳に代わる新規診断法の開発に取り組んでいます. 4) 新生子の主に中枢神経系に発現する毒性変化に関する病理学的研究に取り組んでいます. 幼弱動物は成熟動物と比較して組織的に未発達で, 化学物質などの外来性刺激に高い感受性を示す傾向があります. 化学物質による幼弱動物への影響に関する研究データは乏しく, 化学物質により発現する形態学的変化の機序の解明は毒性病理学的に重要な意義を持ちます.
【受賞歴】 1) JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS AWARD 2014 Kawaguchi H, et al. Rapid Development of Atherosclerosis in the World’s Smallest Microminipig fed a high-fat/high cholesterol diet: A Useful Animal Model Because of its Size and Similarity to Human Pathophysiology. J Atheroscler Thromb. 21:186-203, 2014.
【学術論文】
?Otake M, Kawaguchi H, Enya S, Kangawa A, Koga T, Matsuo K, Yamada S, Rahman MM, Miura N, Shibata M, Tanimoto A. High Pathological Reproducibility of Diet-induced Atherosclerosis in Microminipigs via Cloning Technology. In Vivo. 35:2025-2033, 2021.
?Ijiri M, Lai YC, Kawaguchi H, Fujimoto Y, Miura N, Matsuo T and Tanimoto A. NR6A1 allelic frequencies as an index for both miniaturizing and increasing pig body size. In Vivo. 35:163-167, 2021.
?井端康博, 朴天鎬, 立崎元, 田中成子. 牛の心臓血管過誤腫の1例. 日獣会誌. 74:141-144, 2021.
?Kake S, Kawaguchi H, Nagasato T, Yamada T, Ito T, Maruyama I, Miura N and Tanimoto A. Association Between HMGB1 and Thrombogenesis in a Hyperlipaemia-induced Microminipig Model of Atherosclerosis. In Vivo. 34:1871-1874, 2020.
?Manalo DL, Gomez MR, Jarilla BR, Ang MJ, Tuason LT, Demetria CS, Medina PB, Dilig JE, Avenido-Cervantes EF, Park CH and Inoue S. A preliminary evaluation of a locally produced biotinylated polyclonal anti-rabies antibody for direct rapid immunohistochemical test (DRIT) in the Philippines. Acta Tropica. ?211:105610, 2020.
?Kimitsuki K, Saito N, Yamada K, Park CH, Inoue S, Suzuki M, Saito-Obata M, Kamiya Y, Manalo DL, Demetria CS, Mananggit MR, Quiambao BP and Nishizono A. Evaluation of the diagnostic accuracy of lateral flow devices as a tool to diagnose rabies in post-mortem animals. PLoS Negl Trop Dis. 14:e0008844, 2020.
?Hiura K, Sakanoue A, Kontani1 S, Takahashi Y, Watanabe M, Nakano K, Okamura T, Ando R, Kakuta S, SaSaKi H and Sasaki N. Suppression of tensin 2 promotes intestinal tumorigenesis by liberating integrin-linked kinase-induced nuclear translocation of β-catenin. Translat Regulat Sci. 2: 51-59, 2020.
?Ganbaatar O, Konnai S, Okagawa T, Nojima Y, Maekawa N, Minato E, Kobayashi A, Ando R, Sasaki N, Miyakoshi D, Ichii O, Kato Y, Suzuki Y, Murata S and Ohashi K. PD-L1 expression in equine malignant melanoma and functional effects of PD-L1 blockade. PLoS ONE. 15: e0234218, 2020.
?Rahman MM, Lai YC, Husna AA, Chen HW, Tanaka Y, Kawaguchi H, Miyoshi N, Nakagawa T, Fukushima R and Miura N. Micro RNA transcriptome profile in canine oral melanoma. Int J Mol Sci. 20:4832, 2019.
?Kawaguchi H, Horie M, Onoue K, Noguchi M, Akioka K, Masatani T, Miura N, Ozawa M and Tanimoto A. Development of a model of porcine epidemic diarrhea in Microminipigs. Vet Pathol. 56:711-714, 2019.
?Nakamura N, Hatano E, Iguchi K, Sato M, Kawaguchi H, Ohtsu I, Sakurai T, Aizawa N, Iijima H, Nishiguchi S, Tomono T, Okuda Y, Wada S, Seo S, Taura K, Uemoto S and Ikegawa M. Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study. BMC Cancer. 19:621, 2019.
?Abe M, Kawaguchi H, Miura N, Akioka K, Ushikai M, Oi S, Yukawa A, Yoshikawa T, Izumi H and Horiuchi M. Diurnal Variation of Melatonin Concentration in the Cerebrospinal Fluid of Unanesthetized Microminipig. In Vivo. 32: 583-590, 2018.
?Miyamoto Y, Kawaguchi H and Tanimoto A. Relationship between morphological development and sex hormone receptor expression of mammary glands with age in male rats. Exp Anim. 67:361-371, 2018.
?Shiwa N, Nakajima C, Kimitsuki K, Manalo DL, Noguchi A, Inoue S and Park CH. Follicle sinus complexes (FSCs) in muzzle skin as postmortem diagnostic material of rabid dogs. J. Vet. Med. Sci. 80:1818-1821, 2018.
?Park CH, Shiwa N, Sumimoto J and Kimitsuki K. Epithelial-myoepithelial carcinoma in a canine salivary gland. J. Comp. Pathol. 165: 52-56, 2018.
?Park CH, Shiwa N, Kimitsuki K, Kakizaki T and Watanabe D. Cervical ganglioneuroblastoma in a new born Japanese Black calf. J. Vet. Med. Sci. 80: 755-759, 2018.
?Shiwa N, Kimitsuki K, Manalo DL, Inoue S and Park CH. A pathological study of the tongues of rabid dogs in the Philippines. Arch. Virol. 163: 1615-1621, 2018.
?川口博明, 笹竹 洋, 野口倫子, 秋岡幸兵, 三浦直樹, 武石嘉一朗, 堀内正久, 谷本昭英. 犬の輸送ストレス軽減のための新規鍼治療の試み. 日獣会誌. 69: 143-146, 2016.
?Shimatsu T, Shinozaki H, Kimitsuki K, Shiwa N, Manalo DL, Perez RC, Dilig JE, Yamada K, Boonsriroj H, Inoue S and Park CH. Localization of the rabies virus antigen in Merkel cells in the follicle-sinus complexes of muzzle skins of rabid dogs. J. Virol. Methods. 237: 40-46, 2016.
【総説?その他】
?[Invited Review] Skydsgaard M, Dincer Z, Haschek WM, Helke K, Jacob B, Jacobsen B, Jeppesen G, Kato A, Kawaguchi H, McKeag S, Nelson K, Rittinghausen S, Schaudien D, Vemireddi V and Wojcinski ZW. International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Minipig. Toxicol Pathol. 49:110-228, 2021.
?朴天鎬, 志和希, 君付和範, 井上智. 動物の顔面洞毛組織を用いた狂犬病の新規診断法の開発. MPアグロジャーナル. 36, 41-44, 2019.
?井上智, 野口章, 堀田明豊, 佐藤克, 杉山和寿, 志和希, 朴天鎬. 狂犬病（リッサウイルスによる感染症）日獣会誌. 72: 317-325, 2019.
【著書?翻訳】
?Inoue S, Park CH and Hatta H. Production of monospecific polyclonal rabies virus
antibodies in birds, in Laboratory Techniques in Rabies, 5th edition, WHO. ELSEVIER, 2018. Chapter 40, p.147-156.
V10号館1階
0176-23-4371（内線314）
