分析化学教室
分析化学教室
English
医薬品や生体物質を分析し、得られた知見を創薬につなげる。
当研究室では、医薬品の品質確保に重要な分析法の研究を行っています。また、生体内には、性質や体内での働きが十分に解明されていない物質がたくさん存在しています。例えば、タンパク質や核酸を介した細胞間情報伝達に関与する細胞外小胞や老化等に関与するD型アミノ酸などです。当教室では、これらの性質や体内での動き?働きを分析しています。得られた知見は創薬に役立つと期待されます。業績
Tetsuya Miyamoto, Fugo Kobayashi, Konan Emori, Kumiko Sakai-Kato. Multifunctionality of a low-specificity L-threonine aldolase from the hyperthermophile Thermotoga maritima. Extremophiles, 28: 41. (2024)
Ryoya ibuki*, Takashi Tokui*, Masaya Kuriyama, Kanji Hosoda, Hiroshi Tomoda, Kumiko Sakai-Kato. Effect of lipid composition on the interaction of liposomes with THP-1-derived macropharges. Biological and Pharmaceutical Bulletin 47: 723-731. (2024) (*Equally contributed)
Nanako Endo, Chisa Aoki, Toshihiko Sugiki, Kumiko Sakai-Kato. Quantitative lipid composition characterization of intact liposomes via 31P nuclear magnetic resonance spectroscopy. Analytical Sciences 40: 871-879. (2024)
Tetsuya Miyamoto, Shinya Fushinobu, Yasuaki Saitoh, Masae Sekine, Masumi Katane, Kumiko Sakai-Kato, Hiroshi Homma. Novel tetrahydrofolate-dependent D-serine dehydratase activity of serine hydroxymethyltransferases. The FEBS Journal 291: 308-322. (2024)
Arisa Takeda, Asuka Tachibana, Hiroki Nagumo, Kumiko Sakai-Kato. An in vitro lipid-mixing assay to investigate the fusion between small extracellular vesicles and endosome. Analytical Biochemistry 669: 115130. (2023)
Tetsuya Miyamoto, Yasuaki Saitoh, Masumi Katane, Masae Sekine, Kumiko Sakai-Kato, Hiroshi Homma. Characterization of human cyctathionine g-lyase enzyme activities toward d-amino acids. Bioscience, Biotechnology, and Biochemistry 86(11): 1536-1542. (2022)
Mizuka Nakao, Yuki Takechi-Haraya, Takashi Ohgita, Hiroyuki Saito, Yosuke Demizu, Ken-Ichi Izutsu, Kumiko Sakai-Kato. Analysis of the interaction of cyclosporine congeners with cell membrane models. Journal of Pharmaceutical and Biomedical Analysis 218: 114874. (2022)
Yuki Takechi-Haraya, Takashi Ohgita, Yosuke Demizu, Hiroyuki Saito, Ken-Ichi Izutsu, Kumiko Sakai-Kato. Current status and challenges of analytical methods for evaluation of size and surface modification of nanoparticle-based drug formulations. AAPS PharmSciTech 23: 150. (2022)
Yuki Takechi-Haraya, Takashi Ohgita, Mana Kotani, Hiroki Kono, Chihiro Saito, Hiroko Tamagaki-Asahina, Kazuchika Nishitsuji, Kenji Uchimura, Takeshi Sato, Ryuji Kawano, Kumiko Sakai-Kato, Ken-Ichi Izutsu, Hiroyuki Saito. Effect of hydrophobic moment on membrane interaction and cell penetration of apolipoprotein E-derived arginine-rich amphipathic a-helical peptides. Scientific Reports 12(1): 4959. (2022)