NMR，X線，電子顕微鏡などの構造生物学的手法に加え，質量分析計などの物理化学的測定機器を活用し，生体高分子やその複合体（蛋白質や核酸，阻害活性化合物）を直接目で視てその分子機構を理解することで、生物現象の原子分解能での理解や酵素化学の反応機構解明，さらには，機能改変蛋白質の創製を目指しています．
By employing advanced techniques in structural biology—including NMR spectroscopy, X-ray crystallography, and electron microscopy, coupled with LC-MS/MS—we aim to visualize the three-dimensional structures of biomolecules and their complexes (proteins, nucleic acids, and small molecule inhibitors/activators) at atomic resolution. Our goal is to leverage these approaches to elucidate molecular interactions, uncover catalytic mechanisms in enzymology, and ultimately pave the way for designing proteins with novel or enhanced functionalities.