1. Top>
  2. kitasato>
  3. Research Organization>
  4. Drug Discovery Sciences>
  5. Biological Pharmacology for Phytomedicines
view of the lab with instruments

Laboratory of Biological Pharmacology for Phytomedicines

  • Research
  • Members
  • Publications

Research Synopsis

    Scientific clarification of the mechanisms of preventive/therapeutic effects of Japanese herbal (Kampo) medicines and plant-derived materials on infectious diseases and immunological and neurological disorders and their industrial application.

  1. Comprehensive analysis of Kampo medicines regarding their pharmacological activities, action mechanisms, and active ingredients.
    1. Analysis of the pharmacological activities ofKampomedicines against immunocompromisation and chronic inflammatory diseases from the viewpoint of regulating the mucosal immune system.
    2. Comprehensive analysis of the preventive and therapeutic effects of Kampo medicines on infectious diseases such as influenza.
    3. Comprehensive analysis of the preventive and therapeutic effects of Kampo medicines on emotional disorders including depression.

  2. Scientific clarification of the structures and immunopharmacological activities of macromolecular polysaccharides in herbal medicines and edible plants.

  3. Development of drugs for the regulation of responses to infections and mucosal immune responses and useful seeds based on information concerning the active ingredients of plant-derived materials.
Effect of oral administration of pinellic acid and nasal influenza vaccine on the survival of mice infected with mouse-adapted influenza virus A/PR/8/34.
Effect of Hochuekkito on mucositis in intestine of mice induced by methotrexate

Staff

Kiyohara Hiroaki
Kiyohara Hiroaki
Professor
Nagai Takayuki
Nagai Takayuki
Associate Professor

2012

  1. Kiyohara H., Ichino C., Kawamura Y., Naga T., Sato N., Yamada H.: Patchouli alcohol: in vitro direct anti-influenza virus sesquiterpene in Pogostemon cablin Benth., J. Nat. Med., 66, 55-61 (2012)
  2. Kiyohara H., Ichino C., Kawamura Y., Nagai T., Sato N., Yamada H., Salama M.M., Abdel-Satta E .: In vitro anti-influenza virus activity of a cardiotonic glycoside from Adenium obesum(Forssk.) Phytomedicine, 19, 111-114 (2012)
  3. Otoguro K,, Ishiyama A., Iwatsuki M., Namatame M., Niashihara-Tsukashima A., Kiyohara H., Hashimoto T., Asakawa Y., Omura S., Yamada H. :In vitro antitrypanosomal activity of bis(bibenzyls)s and bibenzyls from liverworts against Trypanosoma burucei, J. Nat. Med., 66, 377-382 (2012)
  4. Sekiya S., Kiyohara H., Maruyama H., Yabe T., Yamada H. : Modulation of chemokine expression on intestinal epithelial cells by Kampo (traditional Japanese herbal) medicine, Hochuekkito, and its active ingredients, J. Nat. Med., doi: 10.1007/s11418-012-0724-1 (2012) Online First
  5. Yamamoto T., Izumi N., Ui H., Sueki A., Masuma R., Nonaka K., Hirose T., Sunazuka T., Nagai T., Yamada H., Omura S., Shiomi K. : Wickerols A and B: novel anti-influenza virus diterpenes produced by Trichoderma atroviride FKI-3849, Tetrahedron, 68, 9267-9271 (2012)
  6. Hokari R., Nagai T., Yamada H. : In vivo anti-influenza virus activity of Japanese herbal (Kampo) medicine, "Shahakusan," and its possible mode of action, Evid. Based Complement. Alternat. Med., doi:10.1155/2012/794970 (2012) Online First

2011

  1. Y. Inahashi, M. Iwatsuki, A. Ishiyama, M. Namatame, A. Nishihara-Tsumashima, A. Matsumoto, T. Hirose, T. Sunazuka, H. Yamada, K. Otoguro, Y. Takahashi, S. Omura and K. Shiomi, :Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolium K07-040(T), J. Antibiot., 64, 303-307 (2011)
  2. H. Oguri, T. Hiura, Y. Yamagishi, H. Oikawa, A. Ishiyama, K. Otoguro, H. Yamada and S. Omura, : Generation of anti-trypanosomal agents through concise synthesis ans structural diversification of sesquiterpene analogues, J. Am. Chem. Soc., 133, 7096-7105 (2011)
  3. C. Singharachai, C. Palanuvej, H. Kiyohara, H. Yamada and N. Ruangrungsi, :Pharmacognostic Specification of Five Root Species in Thai Traditional Medicine Remedy: Ben-Cha-Lo-Ka-Wi-Chian, Pharmacog. J., 3, 1-11 (2011)
  4. C. Singharachai, C. Palanuvej, H. Kiyohara, H. Yamada and N. Ruangrungsi, : Safety evaluation of Thai traditional medicine remedy: Ben-Chao-Lo-Ka-Wi-Chian, J. Health Res., 25, 83-90 (2011)
  5. K. Otoguro, M. Iwatsuki, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, H. Kiyohara, T. Hashimoto, Y. Asakawa, S. Omura and H. Yamada, : In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei, Phytochemistry, 72, 2024-2030 (2011) (doi:10,1016/j.phytochem.2011.070.015)
  6. T. Nagai, S. Makino, S. Ikegami, H. Itoh and H. Yamada, :Effect of oral administration of yogurt fermented with Lactobacillus delbrueckiis  sp. bulgaricusOLL1073R-1 and its polysaccharides against influenza virus infection in mice, Int. Immunopharmacol., 11, 2246-2250 (2011)
  7. H. Kiyohara, C. Ichino, Y. Kawamura, T. Nagai, N. Sato and H. Yamada, : Patchouli alcohol: In vitro direct anti-influenza virus sesquiterpene in Pogostemon cablin Benth., J. Nat. Med., Advance access publication, 66, 55-61 (2012) (DOI 10.1007/s11418-011-0550-x.)

2010

  1. Namba T, Yabe T, Gonda Y, Ichikawa N, Sanagi T, Arikawa-Hirasawa E, Mochizuki H, Kohsaka S, Uchino S. : Pigment epithelium-derived factor up-regulation induced by memantine, an N-methyl-D-aspartate receptor antagonist, is involved in increased proliferation of hippocampal progenitor cells　Neuroscience　167 (2)：372-383　2010
  2. Otoguro K, Iwatsuki M, Ishiyama A, Namatame M, Nishihara-Tsukashima A, Sato S, Hatsu M, Iinuma H, Shibahara S, Nimura S, Kondo S, Yamada H, Omura S : In vitro and in vivo anti-protozoal activities of bispolides and their derivatives　J Antibiot (Tokyo)　63 (5)：275-277　2010
  3. Nagai T, Shimizu Y, Shirahata T, Sunazuka T, Kiyohara H, Omura S, Yamada H : Oral adjuvant activity for nasal influenza vaccines caused by combination of two trihydroxy fatty acid stereoisomers from the tuber of Pinellia ternata　Int Immunopharmacol　10 (6)：655-661　2010
  4. Iwatsuki M, Kinoshita Y, Niitsuma M, Hashida J, Mori M, Ishiyama A, Namatame M, Nishihara-Tsukashima A, Nonaka K, Masuma R, Otoguro K, Yamada H, Shiomi K, Omura S : Antitrypanosomal peptaibiotics, trichosporins B-VIIa and B-VIIb, produced by Trichoderma polysporum FKI-4452　J Antibiot (Tokyo)　63 (6)：331-333　2010
  5. Otoguro K, Iwatsuki M, Ishiyama A, Namatame M, Nishihara-Tukashima A, Shibahara S, Kondo S, Yamada H, Omura S : Promising lead compounds for novel antiprotozoals.　J Antibiot (Tokyo)　63 (7)：381-384　2010
  6. Matsumoto T, Moriya M, Kiyohara H, Tabuchi Y, Yamada H : Hochuekkito, a Kampo (traditional Japanese herbal) medicine, and its polysaccharide portion stimulate G-CSF secretion from intestinal epithelial cells　Evid Based Complement Alternat Med　7 (3)：331-340　2010
  7. Hashida J, Niitsuma M, Iwatsuki M, Mori M, Ishiyama A, Namatame M, Nishihara-Tsukashima A, Nonaka K, Ui H, Masuma R, Otoguro K, Yamada H, Shiomi K, Omura S : Pyrenocine I, a new pyrenocine analog produced by Paecilomycessp. FKI-3573　J Antibiot (Tokyo)　63 (9)：559-561　2010
  8. Otoguro K, Ishiyama A, Iwatsuki M, Namatame M, Nishihara-Tukashima A, Nakashima T, Shibahara S, Kondo S, Yamada H, Omura S :In vitroand in vivoanti-Trypanosoma brucei activities of phenazinomycin and related compounds　J Antibiot (Tokyo)　63 (9)：579-581　2010
  9. Iwatsuki M, Otoguro K, Ishiyama A, Namatame M, Nishihara-Tukashima A, Hashida J, Nakashima T, Masuma R, Takahashi Y, Yamada H, Omura S : In vitro antitrypanosomal activity of 12 low-molecular-weight antibiotics and observations of structure/activity relationships　J Antibiot (Tokyo)　63 (10)：619-622　2010
  10. Niitsuma M, Hashida J, Iwatsuki M, Mori M, Ishiyama A, Namatame M, Nishihara-Tsukashima A, Matsumoto A, Takahashi Y, Yamada H, Otoguro K, Shiomi K, Omura S : Sinefungin VA and dehydrosinefungin V, new antitrypanosomal antibiotics produced by Streptomyces sp. K05-0178　J Antibiot (Tokyo)　63 (11)：673-679　2010
  11. Kiyohara H, Nonaka K, Sekiya M, Matsumoto T, Nagai T, Tabuchi Y, Yamada H : Polysaccharide-containing macromolecules in a Kampo (traditional Japanese herbal) medicine, Hochuekkito: Dual active ingredients for modulation of immune functions on intestinal Peyer's patches and epithelial cells　Evid Based Complement Alternat Med　2011：Article ID 492691, 13 pages　2011
  12. Nagai T, Nakao M, Shimizu Y, Kodera Y, Oh-Ishi M, Maeda T, Yamada H : Proteomic analysis of anti-inflammatory effects of a Kampo (Japanese herbal) medicine "Shoseiryuto (Xiao-Qing-Long-Tang)" on airway inflammation in a mouse model　Evid Based Complement Alternat Med　2011：Article ID 604196, 13 pages　2011
  13. Yabe T, Sanagi T, Yamada H : The neuroprotective role of PEDF: implication for the therapy of neurological disorders　Curr Mol Med　10 (3)：259-266　2010