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細菌感染制御学研究室

  • 研究の概要
  • メンバー
  • 研究業績

研究の概要

ボルデテラ属細菌のエフェクターの機能
細菌感染制御学研究室 HP

教職員?大学院学生

教員

阿部 章夫
阿部 章夫
教授（室長）、感染制御?免疫学部門長

大学院生

  • 小河 俊伸
    博士後期（博士）課程
  • 宮杉 真帆
    博士前期（修士）課程
  • 武 俊文
    博士前期（修士）課程

卒業研究生

  • 中神 茉莉
    理学部生物科学科

平成２８ （２０１６）年度

  1. Akio Abe, Ryutaro Nishimura, and Asaomi Kuwae. : Bordetella effector BopN is tranlocated into host cells via its N-terminal residues. Microbiol. Immunol. 61(6): 206-214 (2017).

平成２７ （２０１５）年度

  1. Asaomi Kuwae, Fumitaka Momose, Kanna Nagamatsu, Yasuharu Suyama, and Akio Abe. : BteA secreted from the Bordetella bronchiseptica type III secretion system induces necrosis through an actin cytoskeleton signaling pathway and inhibits phagocytosis by macrophages. PLoS ONE 11(2): e0148387 (2016).
  2. Akio Abe, Ryutaro Nishimura, Naomichi Tanaka, Jun Kurushima, and Asaomi Kuwae. : The Bordetella secreted regulator BspR is translocated into the nucleus of host cells via its N-terminal moiety: Evaluation of bacterial effector translocation by the Escherichia coli type III secretion system. PLoS ONE 10(8): e0135140 (2015).

平成２６ （２０１４）年度

  1. Keisuke Okada, Yoshitoshi Ogura, Tetsuya Hayashi, Akio Abe, Asaomi Kuwae, Yasuhiko Horiguchi, and Hiroyuki Abe. : Complete genome sequence of Bordetella bronchiseptica S798, an isolate from a pig with atrophic rhinitis. Genome Announc 2(3): e00436-14 (2014).

平成２４ （２０１２）年度

  1. Jun Kurushima, Asaomi Kuwae, Akio Abe : The Type III Secreted Protein BspR Regulates the Virulence Genes in Bordetella bronchiseptica, PLoS ONE 7(6): e38925, 2012
  2. Jun Kurushima, Asaomi Kuwae, Akio Abe : Btc22 chaperone is required for secretion and stability of the type III secreted protein Bsp22 in Bordetella bronchiseptica, FEMS Microbiol. Lett., 331: 144-151, 2012
  3. Jun Kurushima, Asaomi Kuwae, Akio Abe : Iron starvation regulates the type III secretion system in Bordetella bronchiseptica, Microbiology and Immunology, 56: 356-362, 2012
  4. Toshio Fukasawa, Akio Abe, Atsusi Nakamura, Miyako Horigome, Akira Naito : Solid-state NMR spectroscopy reveals anomer specific transport of galactose in the milk yeast Kluyveromyces lactis, FEMS Yeast Res., 12: 415-422, 2012

平成２３ （２０１１）年度

  1. 阿部章夫，桑江朝臣 : 病原細菌のエフェクターの分泌機構と病原性発揮の分子機構, 感染 炎症 免疫, 41: 2-11, 2011
  2. Hyun-Ja Han, Asaomi Kuwae, Akio Abe, Yoshichika Arakawa, Kazunari Kamachi : Differential expression of type III effector BteA protein due to IS481 Insertion in Bordetella pertussis, PLoS ONE, 6: e17797, 2011
  3. Kyota Kimura, Masato Iwatsuki, Takeshi Nagai, Atsuko Matsumoto, Yoko Takahashi, Kazuro Shiomi, Satoshi Omura and Akio Abe : A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacter rodentium, The Journal of Antibiotics, 64: 197-203, 2011

平成２２ （２０１０）年度

  1. Eiji Komatsu, Fuminori Yamaguchi, Akio Abe, Alison A. Weiss, and Mineo Watanabe : Synergic effect of genotype changes in pertussis toxin and pertactin on adaptation to an acellular pertussis vaccine in the murine intranasal challenge model, Clin Vaccine Immunol., 17: 807-12, 2010
  2. Jun Kurushima, Takeshi Nagai, Kanna Nagamatsu, Akio Abe : EspJ effector in enterohemorrhagic E. coli translocates into host mitochondria via an atypical mitochondrial targeting signal, Microbiology and Immunology, 54: 371-379, 2010