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感染症学研究室

  • 研究の概要
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  • 研究業績

研究の概要

研究の概要

髙橋 孝

　感染症学研究室の理念は、science for society、即ち、社会(一般市民あるいは感染症患者)のための科学を実践することである。その実現のために、研究室と社会あるいは医療施設(大学病院?基幹病院?クリニックなど)との連携を大切にしている。現場から頂いた感染症に関する課題?問題点への対処や解決に結び付くようなヒントを連携者へ提示するよう心掛けている。具体的には、呼吸器感染症?皮膚軟部組織感染症?人獣共通感染症?セプシスといった様々領域の疾患や医療施設内での感染管理に関する研究を行っている。以下に挙げる6項目が主たる研究テーマである。くわえて、国際学生交流（大韓民国?慶尚国立大学医学部と北里生命科学研究所）も実践している。

  1. 侵襲性レンサ球菌感染症の播種性病態生理に関する研究
  2. 呼吸器感染症におけるウイルスと病原細菌との病態関連性の解明
  3. ヘリコバクター属菌感染症における病原性に関する解析
  4. 気道ウイルス感染症に対する新たな治療法の開発
  5. 代謝異常(肥満?糖尿病)下の重症感染症の病態生理に関する研究
  6. 効果的な医療関連感染管理に繋がるエビデンスの確立

研究の概要

松井 英則

  1. ヘリコバクター?ハイルマニイ感染症に関する迅速診断?除菌、感染予防技術の開発
    ハイルマニイの感染診断には、胃生検から調製したDNAに含まれるハイルマニイの16S rRNA遺伝子をPCRで検出する方法が用いられている。しかし、内視鏡による生検は大変である上に、菌が寄生する場所を採取しなければならないという問題がある。そこで、ピロリと同時の感染診断を可能とする、血液?尿（ハイルマニイ抗体の検出）、便（組織化学にも使用可能なハイルマニイVHH抗体の利用）を検体とした迅速検査法を開発している。除菌および感染予防においては、ハイルマニイの薬剤耐性に関わる遺伝子解析、狭域スペクトルの新規抗ヘリコバクター剤の開発、乳酸菌による新たな感染防御システムの開発を行っている。
  2. A群連鎖球菌(group A streptococci, GAS)のM蛋白質の受容体であるヒトCD46を発現するCD46トランスジェニックマウスを用いた、急激な骨破壊機構の解析
    皮膚および軟部組織から感染したGASは、血液に侵入後に骨髄内の血管を破壊し滲出する。線維芽細胞を含む骨髄内の細胞表層のCD46にGASが付着し、その刺激により大量のRANKLが発現する。骨髄中の破骨前駆細胞はRANKLにより活性化破骨細胞に分化し、海綿骨から皮質骨に向かって急激な骨吸収を生じる。従ってRANKL抗体の投与により、誘導される骨吸収は抑制できる。
  3. Salmonella enterica serovar Typhimuriumの感染により誘導される免疫応答の解析
    マウスを用いた感染実験などに最適のサルモネラの野生株や各種遺伝子変異株を提供している。また、遺伝子変異や感染実験の助言も行っている。
レンサ球菌の皮膚から皮下組織血管への想定される侵襲経路
伴侶動物やヒトから分離される溶血性レンサ球菌
GAS皮下感染3日後のCD46 Tgマウス脛骨遠位部切片のTRAP染色
GAS皮下感染3日後のCD46 Tgマウス脛骨遠位部切片のTRAP染色。矢印は活性化した破骨細胞を示す。
bは骨を、bmは骨髄を示す。スケールバーは100 ?mを示す。

教職員?大学院学生

教員

髙橋 孝
髙橋 孝
教授（室長）
吉田 春乃
吉田 春乃
助教

大学院生

  • 河原 優哉
    博士前期（修士）課程

研究業績

髙橋 孝

博狗体育在线_狗博体育直播【官方授权网站】@６ （２０２４）年度

  1. Takashi Takahashi, Takahiro Maeda, Haruno Yoshida, Mieko Goto, Yuzo Tsuyuki, and Jae-Seok Kim: Genetic organization of an M protein trans-acting positive regulator (Mga) orthologue and its adjacent M-like protein (SCM) alleles in Streptococcus canis. BMC Res Notes 17 (1): 138, 2024. DOI: 10.1186/s13104-024-06795-8
  2. Yuya Kawara, Mieko Goto, Takahiro Maeda, Haruno Yoshida, Yuzo Tsuyuki, and Takashi Takahashi: Seven draft genome sequences of Streptococcus canis strains, revealing reduced penicillin-G susceptibility. Microbiol Resour Announc 13 (6): e00219-24, 2024. DOI: 10.1128/mra.00219-24
  3. Yuzo Tsuyuki, Takahiro Maeda, Kae Torii, Haruno Yoshida, Noriaki Ikeda, Saki Yoshida, Masahiko Ito, Mieko Goto, and Takashi Takahashi: Antimicrobial resistance patterns of Streptococcus uberis isolates from bovine milk in Chiba prefecture, Japan: association between multidrug resistance and clonal complex 996. J Vet Med Sci 86 (5): 468-473, 2024. DOI: 10.1292/jvms.23-0526
  4. Yoshihiko M. Sakaguchi, Koichiro Murakami, Hiroyuki Akebo, Ryuichi Minoda Sada, Noriyuki Abe, Takahiro Maeda, Mieko Goto, Takashi Takahashi, Yusuke Takahashi, Eriko Kashihara, Jaegi Shim, Hirofumi Miyake, and Kazuhiro Hatta: Successful treatment of streptococcal toxic shock syndrome complicated by primary peritonitis and bilateral empyema in a healthy young woman: Identification of uncommon clone emm103 and novel sequence type 1363. IDCases 35: e01927, 2024. DOI: 10.1016/j.idcr.2024.e01927
  5. Takahiro Maeda, Haruno Yoshida, Noriyuki Abe, Koichiro Murakami, Mieko Goto, and Takashi Takahashi: Draft genome sequence of emm103/ST1363 Streptococcus pyogenes strain AB1, isolated from the blood of a woman with peritonitis and toxic shock syndrome. Microbiol Resour Announc 13 (2): e01027-23, 2024. DOI: 10.1128/mra.01027-23
  6. Haruno Yoshida, Takahiro Maeda, Mieko Goto, Yuzo Tsuyuki, Kenichi Shizuno, and Takashi Takahashi: Ability of Pasteurella canis isolated from host animals and human patients in Japan to invade human keratinocytes: associations between cell invasion ability and host or genotypic traits. Jpn J Vet Res 71 (4): 121-129, 2024. DOI: 10.57494/jjvr.71.4_121
  7. Haruno Yoshida, Yoshiko Takayama, Mieko Goto, Takahiro Maeda, Yuzo Tsuyuki, and Takashi Takahashi: Human keratinocyte entry of noninvasive Streptococcus dysgalactiae subsp. equisimilis from humans and companion animals: relatedness with Lancefield group, source, virulence-associated gene, and antimicrobial resistance phenotype. Jpn J Infect Dis 77 (1): 25-33, 2024. DOI: 10.7883/yoken.JJID.2023.310
  8. Takashi Takahashi, Hyaekang Kim, Han-Sung Kim, Hyun Soo Kim, Wonkeun Song, and Jae-Seok Kim: Comparative genomic analysis of staphylococcal cassette chromosome mec type V Staphylococcus aureus strains and estimation of the emergence of SCCmec V clinical isolates in Korea. Ann Lab Med 44 (1): 47-55, 2024. DOI: 10.3343/alm.2024.44.1.47

博狗体育在线_狗博体育直播【官方授权网站】@５ （２０２３）年度

  1. Daisuke Taniyama, Takahiro Maeda, Takayuki Yokozawa, Akifumi Takano, Toshimi Oda, Sayori Li, Haruno Yoshida, and Takashi Takahashi: Phenotypic and genotypic traits of Pasteurella multocida subsp. septica isolates from the wounds of two patients due to dog or cat biting, 2023. Cureus 15 (7): e42640, 2023. DOI: 10.7759/cureus.42640.
  2. Takahiro Maeda, Mieko Goto, Yuzo Tsuyuki, Sachiko Shibata, Kenichi Shizuno, Haruno Yoshida, Jae-Seok Kim, and Takashi Takahashi: Biotypic and genotypic diversity in Pasteurella canis isolated from host animals and humans: differences in trehalose fermentation and nucleotide sequences encoding trehalose-6-phosphate hydrolase (treC). J Vet Med Sci 85 (8): 858-866, 2023. DOI: 10.1292/jvms.23-0165
  3. Nobuaki Mori, Takahiro Katsumata, and Takashi Takahashi: Prescribed probiotic usage to prevent Clostridioides difficile infection among older patients receiving antibiotics: a retrospective cohort study. J Infect Chemother 29 (9): 833-837, 2023. DOI: 10.1016/j.jiac.2023.05.001
  4. Haruno Yoshida, Jung-Min Kim, Takahiro Maeda, Mieko Goto, Yuzo Tsuyuki, Sachiko Shibata, Kenichi Shizuno, Katsuko Okuzumi, Jae-Seok Kim, and Takashi Takahashi: Virulence-associated genome sequences of Pasteurella canis and unique toxin gene prevalence of P. canis and Pasteurella multocida isolated from humans and companion animals. Ann Lab Med 43 (3): 263-272, 2023. DOI: 10.3343/alm.2023.43.3.263
  5. Takahiro Maeda, Yoshiko Takayama, Mieko Goto, Haruno Yoshida, Tomohiro Fujita, Yuzo Tsuyuki, and Takashi Takahashi: Biofilm production ability of Streptococcus dysgalactiae subsp. equisimilis: associated with host species, Lancefield group, source, clonal complex, and virulence-associated genes. Jpn J Infect Dis 76 (2): 135-144, 2023. DOI: 10.7883/yoken.JJID.2022.579

博狗体育在线_狗博体育直播【官方授权网站】@４ （２０２２）年度

  1. Hiroyuki Yamamoto, Yasuto Fukushima, Yoshihiko Ikeda, Tomoyuki Suda, Mieko Goto, Jun Isogai, Toru Hashimoto, and Takashi Takahashi, and Hidemitsu Ogino: Decisive diagnostic clue for infectious abdominal aortic aneurysm caused by Arthrobacter russicus in a diabetic elderly woman with renal dysfunction: A case report and literature review. Front Cardiovasc Med 9: 1007213, 2022. DOI: 10.3389/fcvm.2022.1007213
  2. Yasuto Fukushima, Yoshiko Takayama, Haruno Yoshida, Mieko Goto, Yuzo Tsuyuki, and Takashi Takahashi: Genogrouping of type II-A CRISPR array in Streptococcus dysgalactiae subsp. equisimilis from humans and companion animals compared to multilocus sequence and emm typing. J Infect Chemother 28 (11): 1571-1574, 2022. DOI: 10.1016/j.jiac.2022.07.009
  3. Goro Kurita, Yuzo Tsuyuki, Sachiko Shibata, Mieko Goto, Takahiro Maeda, Haruno Yoshida, and Takashi Takahashi: Genotypic and phenotypic features of eye-origin Streptococcus canis isolates from dogs in 2021: relatedness with clonal complex 46 and antimicrobial resistance. Jpn J Infect Dis 75 (6): 583-591, 2022. DOI: 10.7883/yoken.JJID.2022.137
  4. Takahiro Maeda, Haruno Yoshida, Jung-Min Kim, Yuzo Tsuyuki, Goro Kurita, Jae-Seok Kim, and Takashi Takahashi: Draft genome sequence of blood-origin Pasteurella canis strain PA42, isolated from a dog in Japan. Microbiol Resour Announc 11 (7): e00260-22, 2022. DOI: 10.1128/mra.00260-22
  5. Eisuke Ogawa, Hirohisa Goto, Hiroyasu Ushimaru, Akemi Matsuo, Satoshi Takeda, Ryohei Nishimura, Takaaki Hondo, and Takashi Takahashi: Vaginal delivery after improvement in COVID-19 by monoclonal antibody treatment: A case report and literature review. J Infect Chemother 28 (7): 982-986, 2022. DOI: 10.1016/j.jiac.2022.02.023
  6. Goro Kurita, Yuzo Tsuyuki, Sachiko Shibata, Megumi Itoh, Mieko Goto, Haruno Yoshida, and Takashi Takahashi: Species identification of β-hemolytic streptococci from diseased companion animals and their antimicrobial resistance patterns in Japan (2021). Jpn J Vet Res 70 (1): 19-28, 2022. DOI: 10.14943/jjvr.70.1.19
  7. Hiroyuki Yamamoto, Katsuya Hashimoto, Hiroyuki Yamada, Yoshihiko Ikeda, Takashi Takahashi, and Toru Hashimoto: Case report: ‘Methicillin-resistant Staphylococcus aureus endocarditis overlying calcified mitral annular abscess misdiagnosed as Klebsiella pneumoniae endocarditis’. Front Microbiol 12: 818219, 2022. DOI: 10.3389/fmicb.2021.818219
  8. Yuzo Tsuyuki, Yasuto Fukushima, and Takashi Takahashi: Characteristics of bacteria isolated in 2017-2020 from Japanese companion animals using blood culture, compared to those isolated in 2014-2016. Kansenshogaku Zasshi 96 (3): 112-117, 2022. DOI: 10.11150/kansenshogakuzasshi.96.112
  9. Takahiro Maeda, Yuzo Tsuyuki, Mieko Goto, Haruno Yoshida, Tomohiro Fujita, and Takashi Takahashi: Dog/cat-origin quinolone-resistant Streptococcus agalactiae isolates with point mutations in quinolone resistance-determining regions: relatedness with clonal complex 10. J Infect Chemother 28 (3): 389-395, 2022. DOI: 10.1016/j.jiac.2021.11.015
  10. Jung-Min Kim, Yasuto Fukushima, Haruno Yoshida, Jae-Seok Kim, and Takashi Takahashi: Comparative genomic features of Streptococcus canis based on pan-genome orthologous group analysis according to sequence type. Jpn J Infect Dis 75 (3): 269-276, 2022. DOI: 10.7883/yoken.JJID.2021.533
  11. Hyoshim Shin, Takashi Takahashi, Seungjun Lee, Eun Hwa Choi, Takahiro Maeda, Yasuto Fukushima, and Sunjoo Kim: Comparing genomic characteristics of Streptococcus pyogenes associated with invasiveness over a 20-year period in Korea. Ann Lab Med 42 (4): 438-446, 2022. DOI: 10.3343/alm.2022.42.4.438
  12. Yasuto Fukushima, Yuzo Tsuyuki, Mieko Goto, Haruno Yoshida, and Takashi Takahashi: Biofilm production ability and other microbiological features of Streptococcus canis. Jpn J Infect Dis 75 (1): 63-69, 2022. DOI: 10.7883/yoken.JJID.2020.1086

博狗体育在线_狗博体育直播【官方授权网站】@３ （２０２１）年度

  1. Hiroyuki Yamamoto, Hiroyuki Yamada, Takahiro Maeda, Mieko Goto, Yoshihiko Ikeda, and Takashi Takahashi: Miniature erupting volcano-shaped mitral valve aneurysm secondary to Streptococcus agalactiae ST1656 endocarditis: A case report. Front Cardiovasc Med 8: 728792, 2021. DOI: 10.3389/fcvm.2021.728792
  2. Yoshiteru Murata, Yuzo Tsuyuki, Daisuke Hayashi, Shigeki Murata, Yasuto Fukushima, Haruno Yoshida, and Takashi Takahashi: Severe soft tissue infection with septic shock caused by Streptococcus canis sequence type 9 harboring M-like protein allele 1 in a miniature dachshund. Jpn J Vet Res 69 (3): 189-194, 2021. DOI: 10.14943/jjvr.69.3.189
  3. Takahiro Maeda, Yasuto Fukushima, Haruno Yoshida, Mieko Goto, Tomohiro Fujita, Yuzo Tsuyuki, and Takashi Takahashi: Biofilm production ability and associated characteristics of Streptococcus agalactiae isolates from companion animals and humans. J Infect Chemother 27 (11): 1571-1577, 2021. DOI: 10.1016/j.jiac.2021.06.018
  4. Haruno Yoshida, Mieko Goto, Takahiro Maeda, Yasuto Fukushima, Tomohiro Fujita, Yuzo Tsuyuki, and Takashi Takahashi: Intracellular invasion ability of Streptococcus agalactiae among non-invasive isolates from human adults and companion animals in Japan. J Infect Chemother 27 (7): 999-1004, 2021. DOI: 10.1016/j.jiac.2021.02.017
  5. Takashi Takahashi, Seungjun Lee, and Sunjoo Kim: Genomic characteristics of Streptococcus agalactiae based on the pan-genome orthologous group analysis according to invasiveness and capsular genotype. J Infect Chemother 27 (6): 814-819, 2021. DOI: 10.1016/j.jiac.2021.01.008
  6. Takahiro Maeda, Yoshiko Takayama, Tomohiro Fujita, Daisuke Taniyama, Yuzo Tsuyuki, Akiyoshi Shibayama, Mieko Goto, Haruno Yoshida, and Takashi Takahashi: Comparison between invasive and non-invasive Streptococcus agalactiae isolates from human adults, based on virulence gene profiles, capsular genotypes, sequence types, and antimicrobial resistance patterns. Jpn J Infect Dis 74 (4): 316-324, 2021. DOI: 10.7883/yoken.JJID.2020.761
  7. Haruno Yoshida, Takashi Takahashi, Hidenori Matsui: A naturally occurring point mutation in the rocA gene of Streptococcus pyogenes confers the highly virulent phenotype. J Infect Chemother 27 (4): 578-584, 2021. DOI: 10.1016/j.jiac.2020.11.009
  8. Haruno Yoshida, Mieko Goto, Yasuto Fukushima, Takahiro Maeda, Yuzo Tsuyuki, and Takashi Takahashi: Intracellular invasion ability and associated microbiological characteristics of Streptococcus canis in isolates from Japan. Jpn J Infect Dis 74 (2): 129-136, 2021. DOI: 10.7883/yoken.JJID.2020.382

博狗体育在线_狗博体育直播【官方授权网站】@２ （２０２０）年度

  1. Toshio Uchikura, Aki Kono, Hiroshi Arino, Takashi Takahashi, and Ichiro Takeuchi: Early surgery for limb preservation in Group A Streptococcus-induced necrotizing soft tissue infection and subsequent soft tissue infection: A case report. IDCases 22: e00980, 2020. DOI: 10.1016/j.idcr.2020.e00980
  2. Yasuto Fukushima, Yoshiteru Murata, Yukie Katayama, Yuzo Tsuyuki, Haruno Yoshida, Tetsuya Mizutani, and Takashi Takahashi: Draft genome sequence of blood-origin Streptococcus canis strain FU149, isolated from a dog with necrotizing soft tissue infection. Microbiol Resour Announc 9 (35): e00737-20, 2020. DOI: 10.1128/mra.00737-20
  3. Jae-Seok Kim, Shoichi Sakaguchi, Yasuto Fukushima, Haruno Yoshida, Takashi Nakano, and Takashi Takahashi: Complete genome sequences of four Streptococcus canis strains isolated from dogs in South Korea. Microbiol Resour Announc 9 (33): e00818-20, 2020. DOI: 10.1128/mra.00818-20
  4. Yuzo Tsuyuki, Sayaka Nakazawa, Setsuko Kubo, Mieko Goto, and Takashi Takahashi: Antimicrobial susceptibility patterns of anaerobic bacteria identified from clinical specimens of diseased dogs and cats. J Vet Med Sci 82 (9): 1316-1320, 2020. DOI: 10.1292/jvms.20-0294.
  5. Daisuke Taniyama, Taketomo Maruki, Takahiro Maeda, Haruno Yoshida, and Takashi Takahashi: Repetitive cellulitis caused by Streptococcus agalactiae isolates with different genotypic and phenotypic features in a patient having upper extremity with lymphedema after mastectomy and axillary lymph node dissection. IDCases 20: e00793, 2020. DOI: 10.1016/j.idcr.2020.e00793
  6. Yasuto Fukushima, Takashi Takahashi , Mieko Goto, Haruno Yoshida, and Yuzo Tsuyuki: Novel diverse sequences of the Streptococcus canis M-like protein (SCM) gene and their prevalence in diseased companion animals: Association of their alleles with sequence types. J Infect Chemother 26 (9): 908-915, 2020. DOI: 10.1016/j.jiac.2020.04.004
  7. Takashi Takahashi, Takahiro Maeda, Seungjun Lee, Dong-Hyun Lee, and Sunjoo Kim: Clonal distribution of clindamycin-resistant erythromycin-susceptible (CRES) Streptococcus agalactiae in Korea based on whole genome sequences. Ann Lab Med 40 (5): 370-381, 2020. DOI: 10.3343/alm.2020.40.5.370
  8. Haruno Yoshida, Yasuto Fukushima, Yukie Katayama, Yuzo Tsuyuki, Tetsuya Mizutani, and Takashi Takahashi: Genome sequences of seven Streptococcus canis strains isolated from diseased companion animals in Japan. Microbiol Resour Announc 9 (16): e00123-20, 2020. DOI: 10.1128/mra.00123-20
  9. Takuhiro Hashiyama, Nobuaki Mori, Yasuto Fukushima, and Takashi Takahashi: Non-necrotizing soft tissue infection and streptococcal toxic shock syndrome caused by a novel Streptococcus pyogenes subtype (emm76.10). Jpn J Infect Dis 73 (5): 373-376, 2020. DOI: 10.7883/yoken.JJID.2020.006
  10. Takahiro Maeda, Yuzo Tsuyuki, Tomohiro Fujita, Yasuto Fukushima, Mieko Goto, Haruno Yoshida, and Takashi Takahashi: Comparison of Streptococcus agalactiae isolates from humans and companion animals reveals genotypic and phenotypic differences. Jpn J Infect Dis 73 (4): 308-315, 2020. DOI: 10.7883/yoken.JJID.2019.441
  11. Yasuto Fukushima, Yuzo Tsuyuki, Mieko Goto, Haruno Yoshida, and Takashi Takahashi: Novel quinolone nonsusceptible Streptococcus canis strains with point mutations in quinolone resistance-determining regions and their related factors. Jpn J Infect Dis 73 (3): 242-249, 2020. DOI: 10.7883/yoken.JJID.2019.392

博狗体育在线_狗博体育直播【官方授权网站】@元 （２０１９）年度

  1. Haruno Yoshida, Yukie Katayama, Yasuto Fukushima, Hirofumi Ohtaki, Kiyofumi Ohkusu, Tetsuya Mizutani, and Takashi Takahashi: Draft genome sequence of Streptococcus canis clinical strain OT1 isolated from a dog owner with invasive infection without a dog bite in Japan. Microbiol Resour Announc 8 (39): e00770-19, 2019. DOI: 10.1128/mra.00770-19
  2. Kenjiro Kawaguchi, Nobuaki Mori, Tokuko Ejima, Yasuhiro Yamada, and Takashi Takahashi: Streptococcal toxic shock syndrome following group A streptococcal vulvovaginitis in a breastfeeding woman. J Infect Chemother 25 (12): 1037-1039, 2019. DOI: 10.1016/j.jiac.2019.05.001
  3. Tomohiro Fujita, Haruno Yoshida, Shunsuke Osaka, Yoneji Hirose, Mieko Goto, Noriyuki Nagano, and Takashi Takahashi: Comparison of characteristics of Streptococcus dysgalactiae subsp. equisimilis isolates causing repetitive vs. single infections. Ann Lab Med 39 (5): 488-492, 2019. DOI: 10.3343/alm.2019.39.5.488
  4. Goro Kurita, Yuzo Tsuyuki, Yoshiteru Murata, and Takashi Takahashi: Reduced rates of antimicrobial resistance in Staphylococcus intermedius group and Escherichia coli isolated from diseased companion animals in an animal hospital after restriction of antimicrobial use. J Infect Chemother 25 (7): 531-536, 2019. DOI: 10.1016/j.jiac.2019.02.017
  5. Haruno Yoshida, Yasuto Fukushima, Mieko Goto, Yuzo Tsuyuki, and Takashi Takahashi: Analysis of the type II-A CRISPR-Cas system in Streptococcus canis isolated from diseased companion animals and one human patient in Japan. Jpn J Infect Dis 72 (4): 261-265, 2019. DOI: 10.7883/yoken.JJID.2018.492
  6. Yasuto Fukushima, Yuzo Tsuyuki, Mieko Goto, Haruno Yoshida, and Takashi Takahashi: Species identification of β-hemolytic streptococci from diseased companion animals and their antimicrobial resistance data in Japan (2017). Jpn J Infect Dis 72 (2): 94-98, 2019. DOI: 10.7883/yoken.JJID.2018.231

平成２８ （２０１６）年度

  1. Fujita T, Horiuchi A, Ogawa M, Yoshida H, Hirose Y, Nagano N, Takahashi T. Genetic diversity in Streptococcus dysgalactiae subsp. equisimilis isolates from patients with invasive and noninvasive infections in a Japanese university hospital (2014-2015). Jpn J Infect Dis. 2017; 70: 100-104.
  2. Taniyama D, Abe Y, Sakai T, Kikuchi T, Takahashi T. Human case of bacteremia caused by Streptococcus canis sequence type 9 harboring the scm gene. IDCases. 2017; 7: 48-52.
  3. Taniyama D, Sakurai M, Sakai T, Kikuchi T, Takahashi T. Human case of bacteremia due to Streptococcus suis serotype 5 in Japan: the first report and literature review. IDCases. 2016; 6: 36-38.
  4. Mori N, Hosoo S, Oyamada Y, Sera Y, Yamada Y, Sugawara M, Higuchi A, Aoki Y, Takahashi T. Characteristics of mucoid Streptococcus pyogenes isolates from two patients with pneumonia in a local community. IDCases. 2016; 6: 43-46.
  5. Matsui H, Nakatani Y, Yoshida H, Takizawa A, Takeuchi O, Overby A, Takahashi T, Murayama SY, Matsuo K. Flesh-eating Streptococcus pyogenes triggers the expression of receptor activator of nuclear factor-kappaB ligand. Cell Microbiol. 2016; 18: 1390-1404.
  6. Yoshida H, Takahashi T, Nakamura M, Overby A, Takahashi T, Ubukata K, Matsui H. A highly susceptible CD46 transgenic mouse model of subcutaneous infection with Streptococcus dysgalactiae subspecies equisimilis. J Infect Chemother. 2016; 22: 229-234.
  7. Shibayama A, Yoshizaki T, Tamaki M, Goto M, Takahashi T. Pyogenic sternoclavicular arthritis caused by Streptococcus agalactiae in an elderly patient with diabetes mellitus. J Am Geriatr Soc. 2016; 64: 1376-1377.

平成２７ （２０１５）年度

  1. Takahashi T, Arai K, Lee DH, Koh E, Yoshida H, Yano H, Kaku M, Kim S. Epidemiological study of erythromycin-resistant Streptococcus pyogenes from Korea and Japan by emm genotyping and multilocus sequence typing. Ann Lab Med. 2016; 36: 9-14.
  2. Ishiki A, Okinaga S, Tomita N, Kawahara R, Tsuji I, Nagatomi R, Taki Y, Takahashi T, Kuzuya M, Morimoto S, Iijima K, Koseki T, Arai H, Furukawa K. Changes in cognitive functions in the elderly living in temporary housing after the Great East Japan Earthquake. PLoS One. 2016; 11: e0147025.
  3. Kajigaya N, Hirose Y, Koike S, Fujita T, Yokota N, Hata S, Ikenaga M, Kobayashi N, Takahashi T. Assessment of contamination using an ATP bioluminescence assay on doorknobs in a university-affiliated hospital in Japan. BMC Res Notes. 2015; 8: 352.
  4. Matsui H, Takahashi T, Overby A, Murayama SY, Yoshida H, Yamamoto Y, Nishiyama K, Seto Y, Takahashi T, Mukai T, Nakamura M. Mouse models for assessing the protective efficacy of Lactobacillus gasseri SBT2055 against Helicobacter suis infection associated with the development of gastric mucosa-associated lymphoid tissue lymphoma. Helicobacter. 2015; 20: 291-298.
  5. Yoshida H, Ishigaki Y, Takizawa A, Moro K, Kishi Y, Takahashi T, Matsui H. Comparative genomics of the mucoid and nonmucoid strains of Streptococcus pyogenes, isolated from the same patient with streptococcal meningitis. Genome Announc. 2015; 3: e00221-15.

平成２６ （２０１４）年度

  1. Yamaguchi N, Matsuba K, Okamoto K, Ueyama T, Matsuba Y, Okuzumi K, Watanabe I, Takahashi T. Rodent macrophage selects vin blanc together with vin rouge according to SO level in situ. Open J Rheumatol Autoimmune Dis. 2014; 4: 240-247.
  2. Shibayama A, Tamaki M, Nagasawa H, Nakamata S, Nakamori Y, Yoshida H, Takahashi T. Necrotizing fasciitis caused by infection with Streptococcus pyogenes harboring emm genotype 11 and sequence type 403. J Exp Clin Med. 2014; 6: 166-167.
  3. Kakuta R, Yano H, Hidaka H, Miyazaki H, Irimada M, Oda K, Arai K, Ozawa D, Takahashi T, Kaku M, Katori Y. Severe acute otitis media caused by mucoid Streptococcus pyogenes in a previously healthy adult. Tohoku J Exp Med. 2014; 232: 301-304.
  4. Sugita C, Tanaka S, Takahashi T. Endobronchial cryptococcosis in a non-HIV immunocompromised patient. J Exp Clin Med. 2014; 6: 105-106.
  5. Takahashi T, Iwamoto A. Measles pneumonia: instructive images by chest computed tomography. J Exp Clin Med. 2014; 6: 72-73.
  6. Yamaguchi N, Kawada N, Jia XF, Okamoto K, Okuzumi K, Chen R, Takahashi T. Overall estimation of anti-oxidant activity by mammal macrophage. Open J Rheumatol Autoimmune Dis. 2014; 4: 13-21.
  7. Takahashi T, Iwamoto A. AIDS-related gastric Kaposi’s sarcoma before and after treatment with pegylated liposomal doxorubicin. J Exp Clin Med. 2014; 6: 62-63.
  8. Takahashi T, Okuro M, Iwai K, Morimoto S. A growing mass in the mediastinum: hiatus hernia. J Exp Clin Med. 2014; 6: 64-65.
  9. Takahashi T, Asami R, Inamatsu T. Legionellosis-associated diarrhea: impressive clinical image. J Exp Clin Med. 2014; 6: 39-40.
  10. Makino T, Nagaba Y, Iguchi H, Okada T, Hirose Y, Yokota N, Kajigaya N, Ikenaga M, Takahashi T. Tuberculous iliopsoas abscess: importance of percutaneous intervention under imaging guidance for diagnosis and drainage. J Exp Clin Med. 2014; 6: 31-32.

平成２５ （２０１３）年度

  1. Matoba T, Nakatani Y, Arai K, Matsui H, Yoshida H, Takahashi T. Interleukin-1beta response of peritoneal macrophages to Streptococcus pyogenes exposure: differential response to living and heat-killed bacteria. J Exp Clin Med. 2013; 5: 227-230.
  2. Yamaguchi N, Wan W, Sakamoto D, Nurmuhammad A, Matsumoto K, Takei T, Okuzumi K, Murayama T, Takahashi T. Regulative effect for natural killer cell by hot spring hydrotherapy-quantitative and qualitative discussion. Open J Immunol. 2013; 3: 201-209.
  3. Takahashi T, Iwamoto A. Perianal fistula caused by intestinal invasive amebiasis in a male patient with AIDS. J Exp Clin Med. 2013; 5: 237-238.
  4. Sadanari H, Murayama T, Zheng X, Yamada R, Matsubara K, Yoshida H, Takahashi T. Inhibitory effects of statins on expression of immediate-early 1 protein of human cytomegalovirus in virus-infected cells. J Exp Clin Med. 2013; 5: 187-193.
  5. Takano F, Bi C, Ishigaki Y, Yoshida H, Sakurada C, Takahashi T. Anticholesteremic agents, statins, modulate monocyte activation in cultured human THP-1 cells. Pharmacometrics. 2013; 84: 75-81.
  6. Ogawa M, Iguchi H, Taoka Y, Yamazaki H, Hirose Y, Yokota N, Kajigaya N, Ikenaga M, Takahashi T. Perirenal and renal abscesses: assessment by multiplanar reformat imaging of computed tomography. J Exp Clin Med. 2013; 5: 120-121.
  7. Takei T, Morozumi M, Ozaki H, Fujita H, Ubukata K, Kobayashi I, Kadota K, Miyamae T, Yokota S, Iwata S, Takahashi T. Clinical features of Mycoplasma pneumoniae infections in the 2010 epidemic season: report of two cases with unusual presentations. Pediatr Neonatol. 2013; 54: 402-405.
  8. Takei T, Chiba N, Fujita H, Morozumi M, Kuwata Y, Kishii K, Ubukata K, Iwata S, Takahashi T. Late onset invasive group B streptococcal infection with serotype VIII in a neonate having congenital biliary atresia. Pediatr Neonatol. 2013; 54: 63-66.

平成２４ （２０１２）年度

  1. Takahashi T, Goto M, Yoshida H, Sumino H, Matsui H. : Infectious diseases after the 2011 Great East Japan Earthquake. J Exp Clin Med. 2012; 4: 20-23.
  2. Murayama T, Li Y, Takahashi T, Yamada R, Matsubara K, Tsuchida Y, Zheng X, Sadanari H. : Anti-cytomegalovirus effects of tricin are dependent on CXCL11. Microbes Infect. 2012; 14: 1086-1092.
  3. Okada T, Morozumi M, Sakata H, Takayanagi R, Ishiwada N, Sato Y, Oishi T, Tajima T, Haruta T, Kawamura N, Ouchi K, Matsubara K, Chiba N, Takahashi T, Iwata S, Ubukata K. : A practical approach estimating etiologic agents using real-time PCR in pediatric inpatients with community-acquired pneumonia. J Infect Chemother. 2012; 18: 832-840.
  4. Ishikawa K, Kanazawa Y, Morimoto S, Takahashi T. : Depopulation with rapid aging in Minamisoma city after the Fukushima Daiichi nuclear power plant accident. J Am Geriatr Soc. 2012; 60: 2357-2358.

平成２３ （２０１１）年度

  1. Hasegawa M, Okada T, Sakata H, Nakayama E, Fuchigami T, Inamo Y, Mugishima H, Tajima T, Iwata S, Morozumi M, Ubukata K, Watanabe H, Takahashi T. : Pandemic (H1N1) 2009-associated pneumonia in children, Japan. Emerg Infect Dis. 2011; 17: 277-280.
  2. Yoshida H, Matsui H, Murayama SY, Takada Y, Matsuo K, Takahashi T, Nakamura M, Ubukata K, Takahashi T. : A CD46 transgenic mouse model for studying the histopathology of arthritis caused by subcutaneous infection with Streptococcus dysgalactiae subspecies equisimilis (SDSE). J Med Microbiol. 2011; 60: 1860-1868.
  3. Takahashi T, Ubukata K, Watanabe H :. Invasive infection caused by Streptococcus dysgalactiae subsp. equisimilis: characteristics of strains and clinical features. J Infect Chemother. 2011; 17: 1-10.
  4. Takahashi T, Iijima K, Kuzuya M, Hattori H, Yokono K, Morimoto S. : Guidelines for non-medical care providers to manage the first steps of emergency triage of elderly evacuees. Geriatr Gerontol Int. 2011; 11: 383-394.

平成２２ （２０１０）年度

  1. Takahashi T, Sunaoshi K, Sunakawa K, Fujishima S, Watanabe H, Ubukata K, and the Invasive Streptococcal Disease Working Group. : Clinical aspects of invasive infections with Streptococcus dysgalactiae subsp. equisimilis in Japan: differences with respect to Streptococcus pyogenes and Streptococcus agalactiae. Clin Microbiol Infect. 2010; 16: 1097-1103.
  2. Hasegawa M, Inamo Y, Fuchigami　T, Hashimoto K, Morozumi M, Ubukata K, Watanabe H, Takahashi T. : Bronchial casts and pandemic (H1N1) 2009 virus infection. Emerg Infect Dis. 2010; 16: 344-346.
  3. Hasegawa M, Hashimoto K, Morozumi M, Ubukata K, Takahashi T, Inamo Y. : Spontaneous pneumomediastinum complicating pneumonia in children infected with the 2009 pandemic influenza A (H1N1) virus. Clin Microbiol Infect. 2010; 16: 195-199.
  4. Matsui H, Sekiya Y, Aikawa C, Murayama SY, Takahashi T, Yoshida H, Takahashi T, Tsuchimoto K, Nakamura M. : Candidatus Helicobacter heilmannii infection in the course of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in human beings and mouse models. Curr Trends Microbiol. 2010; 6: 27-34.

松井　英則（*Corresponding author)

平成２９ （２０１７）年度

  1. 松井英則*, 高橋哲史, 村山琮明, 川口満里奈, 松尾光一, 中村正彦. 乳酸菌が産生する不飽和脂肪酸の抗ヘリコバクター属活性.日本ヘリコバクター学会誌, 19 (2), 2018. in press. Award Report 上原H.pylori賞-優秀賞-
  2. Flahou B.*, Nakamura M., Matsui H., Haesebrouck F.（他29名） Evidence for a primate origin of zoonotic Helicobacter suis colonizing domesticated pigs. ISME J., Sep 08. doi: 10.1038/ismej.2017.145 (Epub date: 2017/09/09), 2017.
  3. Matsui H.*, Takahashi T., Murayama S.Y., Kawaguchi M., Matsuo K., Nakamura M. Protective efficacy of a hydroxyl fatty acid against gastric Helicobacter infections. Helicobacter, 22(4), e12430, 2017.
  4. 松井英則*, 高橋哲史, 中村正彦, 動物実験におけるマイクロバイオームの知見とHelicobacter属感染. Helicobacter Research 21 (3) 65 (251)-69 (255), 2017.
  5. Nakamura M.*, Øverby A., Matsui M. Angiogenesis and lymphangiogenesis in gastric MALT lymphoma: Relation of VEGF and VASH2: Novel therapies for digestive diseases. in Therapeutic targets for inflammation and cancer. Chi Hin Cho (ed.), pp. 177-188., World Scientific. 460 pages doi: 10.1142/9789813148574_0008, 2017.
  6. Nakamura M.*, Øverby A., Uehara A., Oda M., Takahashi S., Murayama S.Y., Matsui H. Significance of cholinergic and peptidergic nerves in stress-induced ulcer and MALT lymphoma formation. Curr. Pharm. Des., 23 (27), 3933-3996, 2017.

平成２８ （２０１６）年度

  1. Matsui H.*, Takahashi T., Murayama S.Y., Uchiyama I., Yamaguchi K., Shigenobu S., Suzuki M., Rimbara E., Shibayama K., Øverby A., Nakamura M. Draft genome sequence of Helicobacter suis strain SNTW101, isolated from a Japanese patient with nodular gastritis. Genome Announc., 4 (5), e00934-16, 2016.
  2. Matsui H.*, Nakatani Y., Yoshida H., Takizawa A., Takeuchi O., Øverby A., Takahashi T., Murayama S.Y., Matsuo K. Fresh-eating Streptococcus pyogenes triggers the expression　of receptor activator of nuclear factor-kB ligand. Cell. Microbiol., 18 (10), 1390-1404, 2016.
  3. Yamamoto T., Matsui H.*, Yamaji K., Takahashi T., Øverby A., Nakamura M., Matsumoto A., Nonaka K., Sunazuka T., ?mura S., Nakano H. Narrow-spectrum inhibitors targeting an alternative menaquinone biosynthetic pathway of Helicobacter pylori. J. Infect. Chemother., 22 (9), 587-592, 2016.
  4. Yoshida H., Takahashi T., Nakamura M., Øverby A., Takahashi T., Ubukata K., Matsui H.* A highly susceptible CD46 transgenic mouse model of subcutaneous infection with Streptococcus dysgalactiae subspecies equisimilis. J. Infect. Chemother., 22 (4), 229-234, 2016.
  5. Kuroda K., Maruyama K., Fujii H., Sugawara I., Ko S.B.H., Yasuda H., Matsui H., Matsuo K.* Osteoprotegerin regulates pancreatic ß-cell homeostasis upon microbial invasion. PLoS ONE, 11 (1), e0146544, 2016.
  6. Aribam S.D., Harada T., Eisheimer-Matulova M., Iwata T., Kanehisa K., Hikono H., Matsui H., Ogawa Y., Shimoji Y. Eguchi M.* Specific monoclonal antibody overcomes the Salmonella enterica serovar Typhimurium’s adaptive mechanisms of intramacrophage survival and replication. PLoS ONE, 11 (3), e0151352, 2016.
  7. 中村正彦*, Anders Øverby, 高橋哲史, 松井英則, 高橋信一, 村山琮明.（トピックス）ピロリ菌陰性でも要注意!?　広義のハイルマニイ菌(Helicobacter heilmannii), 検査と技術 44 (4), 278-284, 2016.
  8. Øverby A., Murayama S.Y., Matsui H., Nakamura M.* In the aftermath of Helicobacter pylori: other helicobacters rising up to become the next gastric epidemic? 　Digestion, 93 (4), 260-265, 2016.
  9. Nakamura M.*, Øverby A., Murayama S.Y., Suzuki H., Takahashi T., Takahashi S., Matsui H. Gastric non-Helicobacter pylori Helicobacter: Its significance in human gastric disease. Springer, Suzuki H., Warren R., Marshall B. (eds), Helicobacter pylori, pp. 131-140., ISBN 978-4-431-55704-3, 329854_1, 2016.

平成２７ （２０１５）年度

  1. Yoshida H., Ishigaki Y., Takizawa A., Moro K., Kishi Y., Takahashi, T., Matsui H.*　Comparative genomics of mucoid and nonmucoid strains of Streptococcus pyogenes isolated from the same patient with streptococcal meningitis. Genome Announc., 3 (2), e00221-15, 2015.
  2. Matsui H.*, Takahashi T., Øverby A., Murayama S.Y., Yoshida H., Yamamoto Y., Nishiyama K., Seto Y., Takahashi T., Mukai T., Nakamura M. Mouse models for assessing the protective efficacy of Lactobacillus gasseri SBT2055 against Helicobacter suis infection associated with the development of gastric mucosa-associated lymphoid tissue lymphoma. Helicobacter, 20 (4), 291-298, 2015.
  3. Matsui H.*, Fukiya S., Kodama-Akahoshi C., Eguchi M., Yamamoto T. Mouse models for assessing the cross-protective efficacy of oral non-typhoidal Salmonella vaccine candidates harboring in-frame deletions of the ATP-dependent protease lon and other genes. J. Med. Microbiol., 64 (Pt 3), 295-302, 2015.
  4. Matsui H.*, Isshiki Y., Eguchi M., Ogawa Y., Shimoji Y. Evaluation of the live vaccine efficacy of virulence plasmid-cured, and phoP- or aroA- deficient Salmonella enterica serovar Typhimurium in mice. J. Vet. Med. Sci., 77 (2), 181-186, 2015.
  5. Yang L., Yamamoto K., Nishiumi S., Nakamura M., Matsui H., Takahashi S., Dohi T., Okada T., Kakimoto K., Hoshi N., Yoshida M.*, Azuma T. Interferon-γ-producing B cells induce the formation of gastric lymphoid follicles after Helicobacter suis infection. Muc. Immunol., 8 (2), 279-295, 2015.
  6. Aribam S.D., Ogawa Y., Matsui H., Hirota J., Okamura M., Akiba M., Shimoji Y., Eguchi M.* Monoclonal antibody-based competitive enzyme-1 linked immunosorbent assay to detect antibodies to O:4 Salmonella in the sera of livestock and poultry. J. Microbiol. Methods, 108, 1-3, 2015.
  7. Aribam S.D., Elshemer-Matulova M., Matsui H., Hirota J., Shiraiwa K., Ogawa Y., Hikono H., Shimoji Y., Eguchi M.* Variation in antigen-antibody affinity among serotype of Salmonella )4 serogroup, determined using specific antisera. FEMS Microbiol. Lett., 362 (21), fnv168, 2015.
  8. Sasaki, M.*, Goji, S., Tamura, Y., Nakamura, M., Matsui, H., Murayama, S.Y., Ebi, M., Ogasawara, N., Funai, Y., Kasugai, K. Helicobacter suis-infected nodular gastritis and a review of diagnostic sensitivity for Helicobacter heilmannii-like organisms. Case Rep. Gastroenterol., 9, 179-187, 2015.
  9. 中村正彦*, 高橋哲史, 松井英則, 高橋信一, 村山琮明, 土本寛二.もうひとつの胃内のHelicobacter属細菌 HHLO, H. heilmannii, H. suis —その発見史、特徴、診断、治療についてー. 日本ヘリコバクター学会誌, 15, 45-52, 2015.

平成２６ （２０１４）年度

  1. Matsui H.*, Takahashi T., Murayama S.Y., Uchiyama I., Yamaguchi K., Shigenobu S., Matumoto T.,Kawakubo M., Horiuchi K., Ota H., Osaki T., Kamiya S., Smet A., Flahou B., Ducatella R., Haesebrouck F., Takahashi S., Nakamura S., Nakamura M. Development of new PCR primers by comparative genomics for the detection of Helicobacter suis in gastric biopsy specimens. Helicobacter, 19 (4), 260-271, 2014. 抄訳版出版
  2. Yamamoto K., Yang Y., Nishium S., Nakamura M. , Matsui H., Takahashi S., Dohi T., Okada T., Kakimoto K., Yoshida M.*, Azuma T., Anti-CXCL13 antibody can inhibit the formation of gastric lymphoid follicles induced by Helicobacter infection. Muc. Immunol., 7 (5), 1244-1254, 2014.
  3. Uchida R., Hanaki H., Matsui H., Hamamoto H., Sekimizu K., Iwatsuki M., Kim Y.P., Tomoda H.* In vitro and in vivo anti-MRSA activities of nosokomycins. Drug. Discov. Ther., 8 (6), 249-254, 2014.
  4. 松井英則*. ヘリコバクター?ピロリ　(Helicobacter pylori), 微生物検査イエローページ　臨床検査増刊号, 58 (11), 1353-1356, 2014.
  5. 松井英則*, 高橋哲史, 中村正彦. Helicobacter suis感染とMALTリンパ腫. 無菌生物, 44 (1), 47-50, 2014.
  6. Nakamura M.*, Takahashi T., Matsui H., Baniwa Y., Takahashi S., Murayama S.Y., Serizawa H., Suzuki H., Hibi T. Alteration of angiogenesis in Helicobacter heilmannii-induced mucosa-associated lymphoid tissue lymphoma: Interaction with c-Met and hepatocyte growth factor. J. Gastroenterol. Hepatol.,29 Suppl 4:70–76, 2014.
  7. Nakamura M.*, Takahashi T., Matsui H., Takahashi S., Murayama S.Y., Suzuki H, Tsuchimoto K. New Pharmaceutical Treatment of Gastric MALT Lymphoma: Anti-angiogenesis treatment using VEGF receptor antibodies and celecoxib. Curr. Pharm. Des., 20, 1097-1103, 2014.