感染制御研究センター

研究の概要
メンバー
研究業績

研究の概要

薬剤耐性 (Antimicrobial resistance; AMR) が世界的な問題となる中、我々は薬剤耐性菌の感染制御に向けた多方面からの研究を展開している。平成 18 年よりこれまで全国規模サーベイランスの実施拠点として、国内の感染症起炎菌の分離状況や薬剤感受性の変動、薬剤耐性菌の分離頻度などの調査を行いながら新規薬剤耐性菌に対する耐性機序の解明を実施している。さらに併用療法を含む治療法に関する基礎研究から新たな感染症治療薬開発に向けた創薬研究を実施するとともに、ベッドサイドや開業医でも使える迅速診断方法の開発を行っている。一方で、院内院外の感染制御を目指し、院内感染対策チームへの協力や、感染症治療ガイドラインの作成に参加している。

日本化学療法学会、日本感染症学会、日本臨床微生物学会による三学会合同抗菌薬感受性サーベイランスの実施拠点として、日本における感染症起炎菌の感受性と動向調査の実施
MRSA, MDRP, MDRA など多剤耐性菌の耐性機序の解明と治療法に関する研究
我が国における肺炎球菌莢膜血清型の疫学調査
イムノクロマト法による感染症迅速診断方法の開発と製品化 ( 企業との共同研究 )
薬剤耐性菌に有効な新規抗感染症薬の創薬研究 ( 学内外の研究機関と共同研究 )
博狗体育在线_狗博体育直播【官方授权网站】@病院及び北里研究所病院の院内感染対策に協力
日本化学療法学会?日本感染症学会の「MRSA 感染症の治療ガイドライン」作成に参加
開発品の抗菌活性評価、医療用医薬品の市販後調査などの受託研究の実施

Emergence and dissemination of antibiotic resistant pathogens thwart efficient chemotherapy in clinical settings worldwide. This laboratory mainly conducts following lines of studies on infection control and surveys of antibiotic resistant bacteria. The laboratory serves as the reference lab for the nation-wide survey program of causative agents of infections, analyzes their antibiotic susceptibility profiles and studies the resistance mechanisms. Search of novel antibiotics amenable to resistant bac- teria. Development of rapid-and-simple diagnosis strategies applicable to private clinics and hospital bed-sides. And active involvement in the infection control team in and out of the University hospital leading towards setting/revision of infection control guidelines.

Projects of major ongoing research

Having been designated as the central laboratory of the Joint Program "Antimicrobial Susceptibility Surveillance” since 2006, we have been conducting surveillance on behalf of three academic societies: the Japanese Society of Chemotherapy (JSC), Japanese Association for Infectious Diseases (JAID), and Japanese Society for Clinical Microbiology (JSCM)
Studies on the resistance mechanisms of multi-drug resistant bacteria including methicillin resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa (MDRP) and Acinetobacter baumannii (MDRA).
Epidemiological studies of capsular polysaccharide serotypes in clinical isolates of Streptococcus pneumoniae
Development of simple-and-rapid diagnostic tests to detect infectious agents by the immunochromatographic method (a joint project with manufacturers)
Search and development of novel antimicrobial agents against MDR bacteria (a joint project with in-house laboratories)
Cooperation with the Infections Control Teams at Kitasato University Hospital and Kitasato Institute Hospital
Participation in the setting and revision of the MRSA treatment guidelines as a joint project with the JSC and JAID
Evaluation of products under development, post-marketing surveys, as commissioned research

　感染制御研究センターは、抗感染症薬研究センターから名称を変更しました。(2015.4.1)

教職員?大学院学生

教員

花木秀明

教授?センター長

松井秀仁

准教授
鈴木由美子

特任助手
吉川紗也香

特任助手

臨時職員

財部裕季子

臨時職員

事務職

河野香世

事務職

大学院生

服部花音

博士前期（修士）課程
山口愛菜

博士前期（修士）課程

研究業績

平成２９（２０１７）年度

Watanabe S, Ohnishi T, Yuasa A, Kiyota H, Iwata S, Kaku M, Watanabe A, Sato J, Hanaki H, Manabe M, Suzuki T, Otsuka F, Aihara M, Iozumi K, Tamaki T, Funada Y, Shinozaki M, Kobayashi M, Okuda M, Kikyo G, Kikuchi K, Okada Y, Takeshima M, Kaneko O, Ogawa N, Ito R, Okuyama R, Shimada S, Shimizu T, Hatta N, Manabu M, Tsutsui K, Tanaka T, Miyachi Y, Asada H, Furukawa F, Kurokawa I, Iwatsuki K, Hide M, Muto M, Yamamoto O, Niihara H, Takagaki K, Kubota Y, Sayama K, Sano S, Furue M, Kanekura T. The first nationwide surveillance of antibacterial susceptibility patterns of pathogens isolated from skin and soft-tissue infections in dermatology departments in Japan. J Infect Chemother. 2017 Aug;23(8):503-511.
Sugawara A, Maruyama H, Shibusawa S, Matsui H, Hirose T, Tsutsui A, Froyman R, Ludwig C, Koebberling J, Hanaki H, Kleefeld G, Omura S, Sunazuka T. 5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity. J Antibiot (Tokyo). 2017 Jul;70(8):878-887.
Yanagihara K, Watanabe A, Aoki N, Matsumoto T, Yoshida M, Sato J, Wakamura T, Sunakawa K, Kadota J, Kiyota H, Iwata S, Kaku M, Hanaki H, Ohsaki Y, Fujiuchi S, Takahashi M, Takeuchi K, Takeda H, Ikeda H, Miki M, Nakanowatari S, Takahashi H, Utagawa M, Nishiya H, Kawakami S, Morino E, Takasaki J, Mezaki K, Chonabayashi N, Tanaka C, Sugiura H, Goto H, Saraya T, Kurai D, Katono Y, Inose R, Niki Y, Takuma T, Kudo M, Ehara S, Sato Y, Tsukada H, Watabe N, Honma Y, Mikamo H, Yamagishi Y, Nakamura A, Ohashi M, Seki M, Hamaguchi S, Toyokawa M, Fujikawa Y, Mitsuno N, Ukimura A, Miyara T, Nakamura T, Mikasa K, Kasahara K, Ui K, Fukuda S, Nakamura A, Morimura M, Yamashita M, Takesue Y, Wada Y, Sugimoto K, Kusano N, Nose M, Mihara E, Kuwabara M, Doi M, Watanabe Y, Tokuyasu H, Hino S, Negayama K, Mukae H, Kawanami T, Ota T, Fujita M, Honda J, Hiramatsu K, Aoki Y, Fukuoka M, Magarifuchi H, Nagasawa Z, Kaku N, Fujita J, Higa F, Tateyama M. Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2012: General view of the pathogens' antibacterial susceptibility. J Infect Chemother. 2017 Jun 29. pii: S1341-321X(17)30133-2.
Takesue Y, Kusachi S, Mikamo H, Sato J, Watanabe A, Kiyota H, Iwata S, Kaku M, Hanaki H, Sumiyama Y, Kitagawa Y, Mizuguchi T, Ambo Y, Konosu M, Ishibashi K, Matsuda A, Hase K, Harihara Y, Okabayashi K, Seki S, Hara T, Matsui K, Matsuo Y, Kobayashi M, Kubo S, Uchiyama K, Shimizu J, Kawabata R, Ohge H, Akagi S, Oka M, Wakatsuki T, Suzuki K, Okamoto K, Yanagihara K. Antimicrobial susceptibility of pathogens isolated from surgical site infections in Japan: Comparison of data from nationwide surveillance studies conducted in 2010 and 2014-2015. J Infect Chemother. 2017 Jun;23(6):339-348.
Fukumoto A, Kim YP, Matsumoto A, Takahashi Y, Suzuki M, Onodera H, Tomoda H, Matsui H, Hanaki H, Iwatsuki M, Omura S, Shiomi K. Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities. J Antibiot (Tokyo). 2017 May;70(5):562-567.
Fukumoto A, Kim YP, Iwatsuki M, Hirose T, Sunazuka T, Hanaki H, Omura S, Shiomi K. Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. II. Structure elucidation. J Antibiot (Tokyo). 2017 May;70(5):568-573.
Hirose T, Kojima Y, Matsui H, Hanaki H, Iwatsuki M, Shiomi K, Omura S, Sunazuka T. Total synthesis of (±)-naphthacemycin A(9), possessing both antibacterial activity against methicillin-resistant Staphylococcus aureus and circumventing effect of β-lactam resistance. J Antibiot (Tokyo). 2017 May;70(5):574-581.

平成２８（２０１６）年度

Takahashi S, Hamasuna R, Yasuda M, Ishikawa K, Hayami H, Uehara S, Yamamoto S, Minamitani S, Kadota J, Iwata S, Kaku M, Watanabe A, Sato J, Hanaki H, Masumori N, Kiyota H, Egawa S, Tanaka K, Arakawa S, Fujisawa M, Kumon H, Wada K, Kobayashi K, Matsubara A, Matsumoto T, Eto M, Tatsugami K, Kuroiwa K, Ito K, Hosobe T, Hirayama H, Narita H, Yamaguchi T, Ito S, Sumii T, Kawai S, Kanokogi M, Kawano H, Chokyu H, Uno S, Monden K, Kaji S, Kawahara M, Takayama K, Ito M, Yoshioka M, Kano M, Konishi T, Kadena H, Nishi S, Nishimura H, Yamauchi T, Maeda S, Horie M, Ihara H, Matsumura M, Shirane T, Takeyama K, Akiyama K, Takahashi K, Ikuyama T, Inatomi H, Yoh M. Nationwide surveillance of the antimicrobial susceptibility of Chlamydia trachomatis from male urethritis in Japan. J Infect Chemother. 2016 Sep;22(9):581-6. 27452428.
Suga T, Shiina M, Asami Y, Iwatsuki M, Yamamoto T, Nonaka K, Masuma R, Matsui H, Hanaki H, Iwamoto S, Onodera H, Shiomi K, Omura S. Paraphaeosphaeride D and berkleasmin F, new circumventors of arbekacin resistance in MRSA, produced by Paraphaeosphaeria sp. TR-022. J Antibiot (Tokyo). 2016 Aug;69(8):605-10.
Hirai J, Hagihara M, Kato H, Sakanashi D, Nishiyama N, Koizumi Y, Yamagishi Y, Suematsu H, Hanaki H, Mikamo H. Investigation on rifampicin administration from the standpoint of pharmacokinetics/pharmacodynamics in a neutropenic murine thigh infection model. J Infect Chemother. 2016 Jun;22(6):387-94.
Sugawara A, Shima H, Sueki A, Hirose T, Matsui H, Nakano H, Hanaki H, Akagawa KS, Omura S, Sunazuka T. Non-antibiotic 12-membered macrolides: design, synthesis and biological evaluation in a cigarette-smoking model. J Antibiot (Tokyo). 2016 Apr;69(4):319-26.

平成２７（２０１５）年度

Okada T, Sato Y, Toyonaga Y, Hanaki H, Sunakawa K. Nationwide survey of Streptococcus pneumoniae drug resistance in the pediatric field in Japan. Pediatr Int. 2016 Mar;58(3):192-201.
Ishikawa K, Hamasuna R, Uehara S, Yasuda M, Yamamoto S, Hayami H, Takahashi S, Matsumoto T, Minamitani S, Kadota J, Iwata S, Kaku M, Watanabe A, Sunakawa K, Sato J, Hanaki H, Tsukamoto T, Kiyota H, Egawa S, Deguchi T, Matsumoto M, Tanaka K, Arakawa S, Fujisawa M, Kumon H, Kobayashi K, Matsubara A, Wakeda H, Amemoto Y, Onodera S, Goto H, Komeda H, Yamashita M, Takenaka T, Fujimoto Y, Tsugawa M, Takahashi Y, Maeda H, Onishi H, Ishitoya S, Nishimura K, Mitsumori K, Ito T, Togo Y, Nakamura I, Ito N, Kanamaru S, Hirose T, Muranaka T, Yamada D, Ishihara S, Oka H, Inatomi H, Matsui T, Kobuke M, Kunishima Y, Kimura T, Ichikawa T, Kagara I, Matsukawa M, Takahashi K, Mita K, Kato M, Okumura K, Kawanishi H, Hashimura T, Aoyama T, Shigeta M, Koda S, Taguchi K, Matsuda Y. Japanese nationwide surveillance in 2011 of antibacterial susceptibility patterns of clinical isolates from complicated urinary tract infection cases. J Infect Chemother. 2015 Sep;21(9):623-33.
Masaki K, Ishii M, Anraku M, Namkoong H, Miyakawa R, Nakajima T, Fukunaga K, Naoki K, Tasaka S, Soejima K, Sayama K, Sugita K, Iwata S, Cui L, Hanaki H, Hasegawa N, Betsuyaku T. Fatal Fulminant Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus Negative for Major High-Virulence Factors Following Influenza B Virus Infection. Am J Case Rep. 2015 Jul 14;16:454-8.
Suzuki K, Kurono Y, Ikeda K, Watanabe A, Iwamoto A, Totsuka K, Kaku M, Iwata S, Kadota J, Hanaki H. Nationwide surveillance of 6 otorhinolaryngological infectious diseases and antimicrobial susceptibility pattern in the isolated pathogens in Japan. J Infect Chemother. 2015 Jul;21(7):483-91.
Ikeda-Dantsuji Y, Hanaki H, Sakai F, Tomono K, Takesue Y, Honda J, Nonomiya Y, Suwabe A, Nagura O, Yanagihara K, Mikamo H, Fukuchi K, Kaku M, Kohno S, Yanagisawa C, Nakae T, Yoshida K, Niki Y. Linezolid-resistant Staphylococcus aureus isolated from 2006 through 2008 at six hospitals in Japan. Kansenshogaku Zasshi. 2015 Jul;Suppl 13:8-14.
Yanagihara K, Kadota J, Aoki N, Matsumoto T, Yoshida M, Yagisawa M, Oguri T, Sato J, Ogasawara K, Wakamura T, Sunakawa K, Watanabe A, Iwata S, Kaku M, Hanaki H, Ohsaki Y, Watari T, Toyoshima E, Takeuchi K, Shiokoshi M, Takeda H, Miki M, Kumagai T, Nakanowatari S, Takahashi H, Utagawa M, Nishiya H, Kawakami S, Kobayashi N, Takasaki J, Mezaki K, Konosaki H, Aoki Y, Yamamoto Y, Shoji M, Goto H, Saraya T, Kurai D, Okazaki M, Niki Y, Yoshida K, Kawana A, Saionji K, Fujikura Y, Miyazawa N, Kudo M, Sato Y, Yamamoto M, Yoshida T, Nakamura M, Tsukada H, Imai Y, Tsukada A, Kawasaki S, Honma Y, Yamamoto T, Ban N, Mikamo H, Sawamura H, Miyara T, Toda H, Sato K, Nakamura T, Fujikawa Y, Mitsuno N, Mikasa K, Kasahara K, Sano R, Sugimoto K, Asari S, Nishi I, Toyokawa M, Miyashita N, Koguchi Y, Kusano N, Mihara E, Kuwabara M, Watanabe Y, Kawasaki Y, Takeda K, Tokuyasu H, Masui K, Negayama K, Hiramatsu K, Aoki Y, Fukuoka M, Magarifuchi H, Nagasawa Z, Suga M, Muranaka H, Morinaga Y, Honda J, Fujita M. Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2010: General view of the pathogens' antibacterial susceptibility. J Infect Chemother. 2015 Jun;21(6):410-20.
Hamasuna R, Yasuda M, Ishikawa K, Uehara S, Hayami H, Takahashi S, Matsumoto T, Yamamoto S, Minamitani S, Watanabe A, Iwata S, Kaku M, Kadota J, Sunakawa K, Sato J, Hanaki H, Tsukamoto T, Kiyota H, Egawa S, Tanaka K, Arakawa S, Fujisawa M, Kumon H, Kobayashi K, Matsubara A, Naito S, Kuroiwa K, Hirayama H, Narita H, Hosobe T, Ito S, Ito K, Kawai S, Ito M, Chokyu H, Matsumura M, Yoshioka M, Uno S, Monden K, Takayama K, Kaji S, Kawahara M, Sumii T, Kadena H, Yamaguchi T, Maeda S, Nishi S, Nishimura H, Shirane T, Yoh M, Akiyama K, Imai T, Kano M. The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013. J Infect Chemother. 2015 May;21(5):340-5.
Baba H, Sato Y, Toyonaga Y, Hanaki H, Sunakawa K. Nationwide survey of the development of drug resistance in the pediatric field in 2007, 2010, and 2012: drug sensitivity of Haemophilus influenzae serotype b strain in Japan. J Infect Chemother. 2015 Apr;21(4):277-83.
Shiro H, Sato Y, Toyonaga Y, Hanaki H, Sunakawa K. Nationwide survey of the development of drug resistance in the pediatric field in 2000-2001, 2004, 2007, 2010, and 2012: evaluation of the changes in drug sensitivity of Haemophilus influenzae and patients' background factors. J Infect Chemother. 2015 Apr;21(4):247-56.
Iwata S, Sato Y, Toyonaga Y, Hanaki H, Sunakawa K. Genetic analysis of a pediatric clinical isolate of Moraxella catarrhalis with resistance to macrolides and quinolones. J Infect Chemother. 2015 Apr;21(4):308-1

平成２６（２０１４）年度

Nihonyanagi S, Sunakawa K, Cui L, Masaki T, Wada T, Hoshiyama T, Nakamura M, Takayama Y, Kanoh Y, Ogawa A, Shichiri M, Hanaki H. A very rare case of primary meningococcal arthritis in an adult male. Clin Case Rep. 2015 Feb;3(2):76-80.
Shoji H, Maeda M, Shirakura T, Takuma T, Hanaki H, Niki Y. Changes in the Distribution of Capsular Serotypes of Streptococcus pneumoniae Isolated from Adult Respiratory Specimens in Japan. Intern Med. 2015;54(11):1337-41.
Uchida R, Hanaki H, Matsui H, Hamamoto H, Sekimizu K, Iwatsuki M, Kim YP, Tomoda H. In vitro and in vivo anti-MRSA activities of nosokomycins. Drug Discov Ther. 2014 Dec;8(6):249-54.
Hanaki H, Cui L, Ikeda-Dantsuji Y, Nakae T, Honda J, Yanagihara K, Takesue Y, Matsumoto T, Sunakawa K, Kaku M, Tomono K, Fukuchi K, Kusachi S, Mikamo H, Takata T, Otsuka Y, Nagura O, Fujitani S, Aoki Y, Yamaguchi Y, Tateda K, Kadota J, Kohno S, Niki Y. Antibiotic susceptibility survey of blood-borne MRSA isolates in Japan from 2008 through 2011. J Infect Chemother. 2014 Sep;20(9):527-34.
Shoji H, Shirakura T, Fukuchi K, Takuma T, Hanaki H, Tanaka K, Niki Y. A molecular analysis of quinolone-resistant Haemophilus influenzae: validation of the mutations in Quinolone Resistance-Determining Regions. J Infect Chemother. 2014 Apr;20(4):250-5.
Uchiyama J, Takemura-Uchiyama I, Kato S, Sato M, Ujihara T, Matsui H, Hanaki H, Daibata M, Matsuzaki S. In silico analysis of AHJD-like viruses, Staphylococcus aureus phages S24-1 and S13', and study of phage S24-1 adsorption. Microbiologyopen. 2014 Apr;3(2):257-70.

平成２５（２０１３）年度

Takata K, Iwatsuki M, Yamamoto T, Shirahata T, Nonaka K, Masuma R, Hayakawa Y, Hanaki H, Kobayashi Y, Petersson GA, Omura S, Shiomi K. Aogacillins A and B produced by Simplicillium sp. FKI-5985: new circumventors of arbekacin resistance in MRSA. Org Lett. 2013 Sep 20;15(18):4678-81.
Matsui H, Kimura J, Higashide M, Takeuchi Y, Okue K, Cui L, Nakae T, Sunakawa K, Hanaki H. Immunochromatographic detection of the group B streptococcus antigen from enrichment cultures. Clin Vaccine Immunol. 2013 Sep;20(9):1381-7.
Hamasuna R, Yasuda M, Ishikawa K, Uehara S, Takahashi S, Hayami H, Yamamoto S, Matsumoto T, Minamitani S, Watanabe A, Iwamoto A, Totsuka K, Kadota J, Sunakawa K, Sato J, Hanaki H, Tsukamoto T, Kiyota H, Egawa S, Tanaka K, Arakawa S, Fujisawa M, Kumon H, Kobayashi K, Matsubara A, Naito S, Tatsugami K, Ito S, Narita H, Kanokogi M, Sumii T, Ito K, Hosobe T, Kawai S, Kawano H, Takayama K, Yamaguchi T, Endo K, Yamauchi T, Maeda S, Yoh M, Horie M, Ito M, Chokyu H, Ihara H, Akiyama K, Uno S, Monden K, Kaji S, Nishimura H, Kawahara M, Sato T, Konishi T, Nishi S, Ishihara S, Yoshioka M. Nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan. J Infect Chemother. 2013 Aug;19(4):571-8.
Hayami H, Takahashi S, Ishikawa K, Yasuda M, Yamamoto S, Uehara S, Hamasuna R, Matsumoto T, Minamitani S, Watanabe A, Iwamoto A, Totsuka K, Kadota J, Sunakawa K, Sato J, Hanaki H, Tsukamoto T, Kiyota H, Egawa S, Tanaka K, Arakawa S, Fujisawa M, Kumon H, Kobayashi K, Matsubara A, Naito S, Tatsugami K, Yamaguchi T, Ito S, Kanokogi M, Narita H, Kawano H, Hosobe T, Takayama K, Sumii T, Fujii A, Sato T, Yamauchi T, Izumitani M, Chokyu H, Ihara H, Akiyama K, Yoshioka M, Uno S, Monden K, Kano M, Kaji S, Kawai S, Ito K, Inatomi H, Nishimura H, Ikuyama T, Nishi S, Takahashi K, Kawano Y, Ishihara S, Tsuneyoshi K, Matsushita S, Yamane T, Hirose T, Fujihiro S, Endo K, Oka Y, Takeyama K, Kimura T, Uemura T. Nationwide surveillance of bacterial pathogens from patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2009 and 2010: antimicrobial susceptibility of Escherichia coli and Staphylococcus saprophyticus. J Infect Chemother. 2013 Jun;19(3):393-403.
Tajima T, Sato Y, Toyonaga Y, Hanaki H, Sunakawa K. Nationwide survey of the development of drug-resistant pathogens in the pediatric field in 2007 and 2010: drug sensitivity of Streptococcus pneumoniae in Japan (second report). J Infect Chemother. 2013 Jun;19(3):510-6.
Hoshino T, Sato Y, Toyonaga Y, Hanaki H, Sunakawa K; Drug-Resistant Pathogen Surveillance Group in Pediatric Infectious Disease. Nationwide survey of the development of drug resistance in the pediatric field in 2007 and 2010: drug sensitivity of Haemophilus influenzae in Japan (second report). J Infect Chemother. 2013 Jun;19(3):495-503.
Matsumoto T, Hanaki H, Kimura T, Nemoto M, Higashihara M, Yokota H, Oda S, Akiyama N, Miyao N, Yoshida M, Yukioka T, Soma K, Ohyashiki K, Suzuki Y, Arai T, Ikegami K, Ichiwata T, Otsuka Y, Kobayashi M, Totsuka K, Sunakawa K; ABK Dose Finding Study Group. Clinical efficacy and safety of arbekacin sulfate in patients with MRSA sepsis or pneumonia: a multi-institutional study. J Infect Chemother. 2013 Feb;19(1):128-37.
Tsutsui A, Hirose T, Ishiyama A, Iwatsuki M, Yokota A, Maruyama H, Matsui H, Otoguro K, Hanaki H, Omura S, Sunazuka T. Antimalarial C-9 oxime derivatives from desmycosin, produced by click chemistry. J Antibiot (Tokyo). 2013 Mar;66(3):191-4.

平成２４（２０１２）年度

Tsutsui A, Hirose T, Ishiyama A, Iwatsuki M, Yokota A, Maruyama H, Matsui H, Otoguro K, Hanaki H, Omura S, Sunazuka T. : Antimalarial C-9 oxime derivatives from desmycosin, produced by click chemistry.　 J Antibiot (Tokyo). 2012 12. doi: 10.1038/ja.2012.113. [Epub ahead of print].
Matsumoto T, Hanaki H, Kimura T, Nemoto M, Higashihara M, Yokota H, Oda S, Akiyama N, Miyao N, Yoshida M, Yukioka T, Soma K, Ohyashiki K, Suzuki Y, Arai T, Ikegami K, Ichiwata T, Otsuka Y, Kobayashi M, Totsuka K, Sunakawa K. ; ABK Dose Finding Study Group.　 Clinical efficacy and safety of arbekacin sulfate in patients with MRSA sepsis or pneumonia: a multi-institutional study.　J Infect Chemother. 2012 Dec 22. [Epub ahead of print].
Matsumoto T, Hanaki H, Kimura T, Nemoto M, Higashihara M, Yokota H, Oda S, Akiyama N, Miyao N, Yoshida M, Yukioka T, Soma K, Ohyashiki K, Suzuki Y, Arai T, Ikegami K, Ichiwata T, Otsuka Y, Kobayashi M, Totsuka K, Sunakawa K. : ABK Dose Finding Study Group. Clinical efficacy and safety of arbekacin sulfate in patients with MRSA sepsis or pneumonia: a multi-institutional study. J Infect Chemother. 2012 Dec 22. [Epub ahead of print].
Tsutsui A, Hirose T, Ishiyama A, Iwatsuki M, Yokota A, Maruyama H, Matsui H, Otoguro K, Hanaki H, Omura S, Sunazuka T. : Antimalarial C-9 oxime derivatives from desmycosin, produced by click chemistry. J Antibiot (Tokyo). 2012 Dec 12. doi: 10.1038/ja.2012.113. [Epub ahead of print].
Takesue Y, Watanabe A, Hanaki H, Kusachi S, Matsumoto T, Iwamoto A, Totsuka K, Sunakawa K, Yagisawa M, Sato J, Oguri T, Nakanishi K, Sumiyama Y, Kitagawa Y, Wakabayashi G, Koyama I, Yanaga K, Konishi T, Fukushima R, Seki S, Imai S, Shintani T, Tsukada H, Tsukada K, Omura K, Mikamo H, Takeyama H, Kusunoki M, Kubo S, Shimizu J, Hirai T, Ohge H, Kadowaki A, Okamoto K, Yanagihara K. : Nationwide surveillance of antimicrobial susceptibility patterns of pathogens isolated from surgical site infections (SSI) in Japan. J Infect Chemother. 2012 Dec;18(6):816-26.
Suga T, Ishii T, Iwatsuki M, Yamamoto T, Nonaka K, Masuma R, Matsui H, Hanaki H, Omura S, Shiomi K. : Aranorosin circumvents arbekacin-resistance in MRSA by inhibiting the bifunctional enzyme AAC(6')/APH(2″). J Antibiot (Tokyo). 2012 Oct;65(10):527-9.
Yuriko Hirao, Yurika Ikeda-Dantsuji, Hidehito Matsui, Masaki Yoshida, Seiji Hori, Keisuke Sunakawa , Taiji Nakae, and Hideaki Hanaki. Low level ß-lactamase production in methicillin-resistant Staphylococcus aureus with ß-lactam-antibiotic-induced vancomycin resistance. BMC Microbiol. 2012 May 8;12(1):69.
Watanabe A, Yanagihara K, Matsumoto T, Kohno S, Aoki N, Oguri T, Sato J, Muratani T, Yagisawa M, Ogasawara K, Koashi N, Kozuki T, Komoto A, Takahashi Y, Tsuji T, Terada M, Nakanishi K, Hattori R, Hirako Y, Maruo A, Minamitani S, Morita K, Wakamura T, Sunakawa K, Hanaki H, Ohsaki Y, Honda Y, Sasaoka S, Takeda H, Ikeda H, Sugai A, Miki M, Nakanowatari S, Takahashi H, Utagawa M, Kobayashi N, Takasaki J, Konosaki H, Aoki Y, Shoji M, Goto H, Saraya T, Kurai D, Okazaki M, Kobayashi Y, Katono Y, Kawana A, Saionji K, Miyazawa N, Sato Y, Watanuki Y, Kudo M, Ehara S, Tsukada H, Imai Y, Watabe N, Aso S, Honma Y, Mikamo H, Yamagishi Y, Takesue Y, Wada Y, Nakamura T, Mitsuno N, Mikasa K, Kasahara K, Uno K, Sano R, Miyashita N, Kurokawa Y, Takaya M, Kuwabara M, Watanabe Y, Doi M, Shimizu S, Negayama K, Kadota J, Hiramatsu K, Morinaga Y, Honda J, Fujita M, Iwata S, Iwamoto A, Ezaki T, Onodera S, Kusachi S, Tateda K, Tanaka M, Totsuka K, Niki Y, Matsumoto T. : Nationwide surveillance of bacterial respiratory pathogens conducted by the Surveillance Committee of Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Clinical Microbiology in 2009: general view of the pathogens' antibacterial susceptibility. J Infect Chemother. 2012 Oct;18(5):609-20.
Yurika Ikeda-Dantsuji, Taiji Nakae, Koichi Ariyoshi, Hidekazu Mizuno, Hidehiko Moriyama, Osanori Nagura, Akira Suwabe, Kunihiko Fukuchi, Junichi Honda, Mitsuo Kaku, Shigeru Kohno, Hiroshige Mikamo, Yoshihito Niki, Yoshio Takesue, Kazunori Tomono, Katsunori Yanagihara, and Hideaki Hanaki. : Limited detectability of linezolid-resistant Staphylococcus aureus by the Etest method and its improvement using enriched media. J Med Microbiol. 2012 Jul;61(Pt 7):998-1002.
Nihonyanagi S, Adachi Y, Onuki T, Nakazaki N, Hirata Y, Fujiki K, Takayama Y, Kanoh Y, Bandoh Y, Dantsuji Y, Hanaki H, Sunakawa K. : Emergence of linezolid-resistant Enterococcus faecalis strains from two inpatients in a pediatric ward. Kansenshogaku Zasshi. 2012 Sep;86(5):555-62. Japanese.
Longzhu Cui, Hui-min Neoh, Akira Iwamoto, and Keiichi Hiramatsu. : Coordinated phenotype switching with large-scale chromosome flip-flop inversion observed in bacteria. PNAS. 2012 June 19;109(25): E1647-1656.

平成２３（２０１１）年度

Masato Iwatsuki, Toshiya Ishimori, Tsuyoshi Yamamoto, Keiko Takata, Mihoko Mori, Kenichi Nonaka, Rokuro Masuma, Yoichi Hayakawa, Hideaki Hanaki, Kazuro Shiomi , Satoshi _Omura : a. Biverlactones AeD, new circumventors of arbekacin resistance in MRSA, produced by Penicillium sp. FKI-4429. Tetrahedron. 2011, 67:6644-6648.
Niki Y, Hanaki H, Matsumoto T, Yagisawa M, Kohno S, Aoki N, Watanabe A, Sato J, Hattori R, Koashi N, Terada M, Kozuki T, Maruo A, Morita K, Ogasawara K, Takahashi Y, Matsuda K, Nakanishi K, Sunakawa K, Takeuchi K, Fujimura S, Takeda H, Ikeda H, Sato N, Niitsuma K, Saito M, Koshiba S, Kaneko M, Miki M, Nakanowatari S, Takahashi H, Utagawa M, Nishiya H, Kawakami S, Aoki Y, Chonabayashi N, Sugiura H, Ichioka M, Goto H, Kurai D, Saraya T, Okazaki M, Yoshida K, Yoshida T, Tsukada H, Imai Y, Honma Y, Yamamoto T, Kawai A, Mikamo H, Takesue Y, Wada Y, Miyara T, Toda H, Mitsuno N, Fujikawa Y, Nakajima H, Kubo S, Ohta Y, Mikasa K, Kasahara K, Koizumi A, Sano R, Yagi S, Takaya M, Kurokawa Y, Kusano N, Mihara E, Nose M, Kuwabara M, Fujiue Y, Ishimaru T, Matsubara N, Kawasaki Y, Tokuyasu H, Masui K, Kido M, Ota T, Honda J, Kadota J, Hiramatsu K, Aoki Y, Nagasawa Z, Yanagihara K, Fujita J, Tateyama M, Totsuka K. : Nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy in 2008: general view of the pathogens' antibacterial susceptibility. J Infect Chemother. 2011 Mar 17(4):510-23.
Ikeda-Dantsuji Y, Hanaki H, Nakae T, Takesue Y, Tomono K, Honda J, Yanagihara K, Mikamo H, Fukuchi K, Kaku M, Kohno S, Niki Y. : Emergence of linezolid-resistant mutants in the susceptible cell population of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2011 May,55(5):2466-8.
Ishikawa K, Matsumoto T, Yasuda M, Uehara S, Muratani T, Yagisawa M, Sato J, Niki Y, Totsuka K, Sunakawa K, Hanaki H, Hattori R, Terada M, Kozuki T, Maruo A, Morita K, Ogasawara K, Takahashi Y, Matsuda K, Hirose T, Miyao N, Hayashi T, Takeyama K, Kiyota H, Tomita M, Yusu H, Koide H, Kimura S, Yanaoka M, Sato H, Ito T, Deguchi T, Fujimoto Y, Komeda H, Asano Y, Takahashi Y, Ishihara S, Arakawa S, Nakano Y, Tanaka K, Fujisawa M, Matsui T, Fujii A, Yamamoto S, Nojima M, Higuchi Y, Ueda Y, Kanamaru S, Monden K, Tsushima T, Seno Y, Tsugawa M, Takenaka T, Hamasuna R, Fujimoto N, Sho T, Takahashi K, Inatomi H, Takahashi N, Ikei Y, Hayami H, Yamane T, Nakagawa M, Kariya S, Arima T. : The nationwide study of bacterial pathogens associated with urinary tract infections conducted by the Japanese Society of Chemotherapy. J Infect Chemother2011 Feb;17(1):126-38.
Matsui H, Hanaki H, Inoue M, Akama H, Nakae T, Sunakawa K, Omura S. : Development of an Immunochromatographic Strip for Simple Detection of Penicillin Binding Protein 2'. Clin Vaccine Immunol. 2011 Feb;18(2):248-53.

平成２２（２０１０）年度

Sakai F, Hanaki H, Barada K, Hirao Y, Inamatsu T, Nakae T, Sunakawa K. : A 25-year trace of methicillin-resistant Staphylococcus aureus dissemination in a geriatric hospital in Japan. Int J Gen Med. 2010 Dec 9;3:399-405.
Sakai F, Hanaki H, Ikeda-Dantsuji Y, Hirao Y, Nonoyama M, Iwata S, Sato Y, Akita H, Nakae T, Sunakawa K. : Trends in empirical chemotherapy of bacterial meningitis in children aged more than 4 months in Japan: a survey from 1997 through 2008.　J Infect Chemother. 2010 Sep 29.
Kobayashi Y, Ichioka M, Hirose T, Nagai K, Matsumoto A, Matsui H, Hanaki H, Masuma R, Takahashi Y,　Omura S, Sunazuka T. :Bottromycin derivatives: efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6116-20.
Ikeda-Dantsuji Y, Hanaki H, Sakai F, Tomono K, Takesue Y, Honda J, Nonomiya Y, Suwabe A, Nagura O, Yanagihara K, Mikamo H, Fukuchi K, Kaku M, Kohno S, Yanagisawa C, Nakae T, Yoshida K, Niki Y. : Linezolid-resistant Staphylococcus aureus isolated from 2006 through 2008 at six hospitals in Japan. J Infect Chemother. 2011 Feb;17(1):45-51.
Ikeda S, Hanaki H, Yanagisawa C, Ikeda-Dantsuji Y, Matsui H, Iwatsuki M, Shiomi K, Nakae T, Sunakawa K, Omura S. : Identification of the active component that induces vancomycin resistance in MRSA. J Antibiot (Tokyo)2010 Sep;63(9):533-8.
Ishihara K, Shimokubo N, Sakagami A, Ueno H, Muramatsu Y, Kadosawa T, Yanagisawa C, Hanaki H, Nakajima C, Suzuki Y, Tamura Y. : Occurrence and molecular characteristics of methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus pseudintermedius in an academic veterinary hospital. Appl Environ Microbiol2010 Aug;76(15):5165-74.
Higuchi W, Mimura S, Kurosawa Y, Takano T, Iwao Y, Yabe S, Razvina O, Nishiyama A, Ikeda-Dantsuji Y, Sakai F, Hanaki H, Yamamoto T. : Emergence of the community-acquired methicillin-resistant Staphylococcus aureus USA300 clone in a Japanese child, demonstrating multiple divergent strains in Japan. J Infect Chemother2010 Aug;16(4):292-7.
Higuchi W, Hung WC, Takano T, Iwao Y, Ozaki K, Isobe H, Teng LJ, Shimazaki T, Honda A, Higashide M, Hanaki H, Yamamoto T. : Molecular characteristics of the Taiwanese multiple drug-resistant ST59 clone of Panton-Valentine leucocidin-positive community-acquired methicillin-resistant Staphylococcus aureus from pediatric cellulitis.　 J Infect Chemother. 2010. Apr;16(2):144-9.