医療系研究科在学生がEuropean Society of Cardiology Congress 2024でNursing Allied Professions Investigator Awardを受賞しました。

添田さんは、『Impact of agitation status during intensive care on functional outcomes and mortality in patients with cardiovascular disease 』について発表を行いました。

Background
Since patients with cardiovascular disease (CVD) requiring intensive care were ageing and thereby had low-stress responses, including changes in mental status, optimal management of sedation and agitation statuses during intensive care is considered crucial.
However, the influence of detailed agitation levels during CVD treatment in the ICU on clinical outcomes after ICU discharge is still unclear.

Purpose
To investigate the associations of the agitation level during ICU stay with mortality after ICU admission and functional outcomes at hospital discharge.

Results
During the median follow-up of 1.9 years, all-cause death occurred in 280 patients (12.5%), with an incidence rate of 5.57/100 person-years. The Restless and Agitation groups showed higher mortality than the Calm group (P<0.001), and higher agitation levels in the ICU were significantly associated with a higher rate of all-cause mortality (adjusted hazard ratio: 1.37, 95% confidence intervals: 1.19-1.57, P<0.001).
Furthermore, as compared with the Calm group, the Restless and Agitation groups showed significantly lower levels of 6MWD (all P<0.001) and Mini-cog (P=0.004 and P<0.001, respectively) and a higher PHQ-2 (all P<0.001), even after adjusting for clinical confounders.

Conclusions
The high agitation level during ICU stay in CVD patients was robustly associated with poor prognosis and lower functional outcomes at hospital discharge.
Detailed information on the agitation status during intensive care may be an important indicator in developing management and treatment strategies for patients with CVD admitted to ICU.